🔬 Electron microscopy and fluorescence enthusiast - in situ imaging of bone marrow, especially the incredible #megakaryocyte in #cancer
📍Strasbourg, France
Using high-resolution 3D imaging, we mapped ECM proteins around MKs.
Surprisingly, laminin and collagen IV form a 3D cage that completely surrounds MKs and connects to the sinusoidal basement membrane.
👉 This “ECM cage” stabilizes MKs in their vascular niche.
Using high-resolution 3D imaging, we mapped ECM proteins around MKs.
Surprisingly, laminin and collagen IV form a 3D cage that completely surrounds MKs and connects to the sinusoidal basement membrane.
👉 This “ECM cage” stabilizes MKs in their vascular niche.
Our latest paper on the role of the extracellular matrix (ECM) in megakaryopoiesis is out in @elife.bsky.social !
🔗 elifesciences.org/articles/104...
I’m thrilled to share this story with you in a short thread 👇
Our latest paper on the role of the extracellular matrix (ECM) in megakaryopoiesis is out in @elife.bsky.social !
🔗 elifesciences.org/articles/104...
I’m thrilled to share this story with you in a short thread 👇