Cake time!!! We literally ate our model!! and ...it is delicious😋

Finally, it has been invaluable experience to co-lead this project with my amazing mentors @Alf_Castello and @shabazlab.bsky.social who showed me the beauty of integrating RNA biology with proteomics to explore the hidden aspects of virus infection.

Among these proteins, the U2 snRNP including U2 snRNA appears to assemble on the viral RNA and inhibit viral replication in U2 snRNA -dependent manner.

Additional data shows that these relocalised nuclear proteins can be found in proximity of virus replication centers in the cytoplasm

Subcellular fractionation and proteomics shows 1) these nuclear proteins relocalise to the cytoplasm upon infection and 2) Viral RNA is their main destination

It is all started with the observation that some strictly nuclear proteins, with no known cytoplasmic function, interact with cytoplasmic viral RNA during SINV infection.