Vivek Bhardwaj
@vivekbhr.bsky.social
Assistant Prof. @Utrecht University (NL). I study epigenetic regulation of cell fates using single-cell genomics and data science. Previously at Max Planck-IE (DE) and Hubrecht Institute (NL). https://vblab.org
Reposted by Vivek Bhardwaj
CONCLUSIONS:
To promote the best science being done, we need to look at the incentives of science publishing and funding. Long-term funding produces better science. Short-term and topical agendas encourages irreproducibility.
Funding model organisms generates science we can build on! 🪰🪱🦠🐠🐁🐸
6/6 🧵
To promote the best science being done, we need to look at the incentives of science publishing and funding. Long-term funding produces better science. Short-term and topical agendas encourages irreproducibility.
Funding model organisms generates science we can build on! 🪰🪱🦠🐠🐁🐸
6/6 🧵
July 10, 2025 at 8:23 AM
CONCLUSIONS:
To promote the best science being done, we need to look at the incentives of science publishing and funding. Long-term funding produces better science. Short-term and topical agendas encourages irreproducibility.
Funding model organisms generates science we can build on! 🪰🪱🦠🐠🐁🐸
6/6 🧵
To promote the best science being done, we need to look at the incentives of science publishing and funding. Long-term funding produces better science. Short-term and topical agendas encourages irreproducibility.
Funding model organisms generates science we can build on! 🪰🪱🦠🐠🐁🐸
6/6 🧵
Reposted by Vivek Bhardwaj
A new #zebrafish reference genome assembly (GRCz12tu) has been posted at GenBank! Special thanks to @burgesslab.bsky.social, NCBI, and the GRC for their immeasurable work 🔥 It is not yet annotated, but that will be forthcoming. www.ncbi.nlm.nih.gov/datasets/gen... h/t Monte Westerfield on ZR! Slack
Danio rerio genome assembly GRCz12tu
- Danio rerio
www.ncbi.nlm.nih.gov
April 8, 2025 at 7:46 PM
A new #zebrafish reference genome assembly (GRCz12tu) has been posted at GenBank! Special thanks to @burgesslab.bsky.social, NCBI, and the GRC for their immeasurable work 🔥 It is not yet annotated, but that will be forthcoming. www.ncbi.nlm.nih.gov/datasets/gen... h/t Monte Westerfield on ZR! Slack
Very important work #epigenomics, as we almost never image the cells when performing CnR/CnT experiments
🚨 Preprint alert 🚨
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...
Ab-trapping - a peripheral staining artifact in antibody-based microscopy and genomics
Antibodies (Ab) are essential for detecting specific epitopes in microscopy and genomics, but can produce artifacts leading to erroneous interpretations. Here, we characterize a novel artifact, Ab-tra...
doi.org
April 18, 2025 at 9:26 AM
Very important work #epigenomics, as we almost never image the cells when performing CnR/CnT experiments
New story from @marloes3105.bsky.social shows new insights towards optimizing the in vitro models of mouse embryogenesis.
Very happy to share that our paper on stem cell culture conditions is now out! doi.org/10.1371/jour... We found that modulating mESC culture conditions influences gastruloid elongation and lineage specification, and helps with making the protocol more reproducible in our hands! more below 🧵⬇️ [1/7]
Stem cell culture conditions affect in vitro differentiation potential and mouse gastruloid formation
Aggregating low numbers of mouse embryonic stem cells (mESCs) and inducing Wnt signalling generates ‘gastruloids’, self-organising complex structures that display an anteroposterior organisation of ce...
doi.org
March 28, 2025 at 7:15 PM
New story from @marloes3105.bsky.social shows new insights towards optimizing the in vitro models of mouse embryogenesis.