It is through clinical trials that new treatments are discovered, tested, and approved.

A medicine is a chemical and will stay so in the absence of clinical trials.

No trial, no medicines.
I’m thankful for colleagues who run clinical trials.
#ASH24

9. All the active drugs for myeloma in one simple table. Black font = approved drugs; blue font = investigational.

8. Will post hot-of-the-press smoldering myeloma SMM treatment algorithm Monday afternoon #ASH24

AQUILA trial!
Stay tuned.

7. For more details check out my 2024 Annual myeloma diagnosis and treatment update published in Am J Hematology. #OpenAccess
#ASH24 onlinelibrary.wiley.com/doi/10.1002/...

6. In general if possible and available a clinical trial is preferable to these algorithms.

These are general principles. You have to individualize treatment selection. Also treatments evolve. Follow msmart.org for updates
@MayoMyeloma #ASH24

5. True Penta-Refractory myeloma (refractory to PI, Imid, CD38, alkylator, and BCMA targeted approach).
msmart.org #ASH24

4. Second or later relapse
mSMART.org #ASH24

3) First Relapse

I don’t recommend CART in first relapse even though it’s approved except in very selected patients (eg., high risk progressing early while on quad).

msmart.org #ASH24

2. Newly diagnosed transplant eligible. Quadruplet induction.

See below for transplant timing and maintenance. #ASH24