Our comprehensive Review on MGUS: Monoclonal Gammopathy of Undetermined Significance @NEJM

5% of people over age 50 have MGUS. Every physician needs to know and understand MGUS. Lots of Tables and Figures. www.nejm.org/doi/abs/10.1...

9. All the active drugs for myeloma in one simple table. Black font = approved drugs; blue font = investigational.

5. True Penta-Refractory myeloma (refractory to PI, Imid, CD38, alkylator, and BCMA targeted approach).
msmart.org #ASH24

4. Second or later relapse
mSMART.org #ASH24

3) First Relapse

I don’t recommend CART in first relapse even though it’s approved except in very selected patients (eg., high risk progressing early while on quad).

msmart.org #ASH24

2. Newly diagnosed transplant eligible. Quadruplet induction.

See below for transplant timing and maintenance. #ASH24

My Annual Updated Myeloma Treatment Algorithms thread. Bookmark! #ASH24
#ASH24VR

1. Newly diagnosed transplant ineligible. Quadruplet unless frail. Maintenance varies by risk stratification.