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#NobelPrize #Immunology #ScienceCommunication #AutoimmuneDiseases #Physiology #Medicine #RegulatoryTCells #SpatialBiology #ScientificBreakthrough
October 6, 2025 at 4:49 PM
👏 A huge congratulations to Brunkow, Ramsdell, and Sakaguchi for helping us better understand the delicate balance of immunity and tolerance. The immune system’s true sophistication lies in its ability to distinguish between threat and self—and to choose peace when needed.
October 6, 2025 at 4:49 PM
👏 A huge congratulations to Brunkow, Ramsdell, and Sakaguchi for helping us better understand the delicate balance of immunity and tolerance. The immune system’s true sophistication lies in its ability to distinguish between threat and self—and to choose peace when needed.
Their discoveries have reshaped modern immunology and are already influencing clinical trials and therapeutic strategies.
October 6, 2025 at 4:49 PM
Their discoveries have reshaped modern immunology and are already influencing clinical trials and therapeutic strategies.
Why does this matter?
🔹 It opens new doors to treating autoimmune diseases
🔹 It helps improve cancer therapies by fine-tuning immune responses
🔹 It reduces complications in stem cell transplants
🔹 It opens new doors to treating autoimmune diseases
🔹 It helps improve cancer therapies by fine-tuning immune responses
🔹 It reduces complications in stem cell transplants
October 6, 2025 at 4:49 PM
Why does this matter?
🔹 It opens new doors to treating autoimmune diseases
🔹 It helps improve cancer therapies by fine-tuning immune responses
🔹 It reduces complications in stem cell transplants
🔹 It opens new doors to treating autoimmune diseases
🔹 It helps improve cancer therapies by fine-tuning immune responses
🔹 It reduces complications in stem cell transplants
Their work revealed how the body maintains "peripheral immune tolerance," which means teaching immune cells to tolerate our own tissues even outside the central training zone (the thymus).
October 6, 2025 at 4:49 PM
Their work revealed how the body maintains "peripheral immune tolerance," which means teaching immune cells to tolerate our own tissues even outside the central training zone (the thymus).
The Nobel-winning trio uncovered a critical part of the immune system called regulatory T cells. Think of them as peacekeepers or referees. These cells help the immune system stay calm and avoid friendly fire.
October 6, 2025 at 4:49 PM
The Nobel-winning trio uncovered a critical part of the immune system called regulatory T cells. Think of them as peacekeepers or referees. These cells help the immune system stay calm and avoid friendly fire.
In simple terms: our immune system is like a powerful security force. It’s trained to detect and destroy invaders like viruses and bacteria. But sometimes, it gets confused and starts attacking our own healthy cells. This is what happens in autoimmune diseases like type 1 diabetes, lupus, or MS
October 6, 2025 at 4:49 PM
In simple terms: our immune system is like a powerful security force. It’s trained to detect and destroy invaders like viruses and bacteria. But sometimes, it gets confused and starts attacking our own healthy cells. This is what happens in autoimmune diseases like type 1 diabetes, lupus, or MS
📌 Bottom Line:
Whether you're decoding rare variants or just curious about the future of medicine, this project is a powerful reminder of how science and data can come together to improve lives.
🔗 You can explore the full study here: www.nature.com/articles/s41....
Whether you're decoding rare variants or just curious about the future of medicine, this project is a powerful reminder of how science and data can come together to improve lives.
🔗 You can explore the full study here: www.nature.com/articles/s41....
Whole-genome sequencing of 490,640 UK Biobank participants - Nature
A study reports whole-genome sequences for 490,640 participants from the UK Biobank and combines these data with phenotypic data to provide new insights into the relationship between human variation a...
www.nature.com
September 8, 2025 at 7:32 PM
📌 Bottom Line:
Whether you're decoding rare variants or just curious about the future of medicine, this project is a powerful reminder of how science and data can come together to improve lives.
🔗 You can explore the full study here: www.nature.com/articles/s41....
Whether you're decoding rare variants or just curious about the future of medicine, this project is a powerful reminder of how science and data can come together to improve lives.
🔗 You can explore the full study here: www.nature.com/articles/s41....
• And because this data is open to researchers worldwide, it’s accelerating discoveries that could benefit global health.
September 8, 2025 at 7:32 PM
• And because this data is open to researchers worldwide, it’s accelerating discoveries that could benefit global health.
• It could lead to better diagnostics, safer medications, and more personalized treatments based on your unique genetic makeup.
September 8, 2025 at 7:32 PM
• It could lead to better diagnostics, safer medications, and more personalized treatments based on your unique genetic makeup.
💡 For Everyone Else:
• Think of this as a giant genetic encyclopedia—built from real people—that helps scientists understand why some people get sick and others don’t.
• Think of this as a giant genetic encyclopedia—built from real people—that helps scientists understand why some people get sick and others don’t.
September 8, 2025 at 7:32 PM
💡 For Everyone Else:
• Think of this as a giant genetic encyclopedia—built from real people—that helps scientists understand why some people get sick and others don’t.
• Think of this as a giant genetic encyclopedia—built from real people—that helps scientists understand why some people get sick and others don’t.
• The data enables fine-mapping of genetic traits, supports drug target discovery, and strengthens the foundation for precision medicine.
September 8, 2025 at 7:32 PM
• The data enables fine-mapping of genetic traits, supports drug target discovery, and strengthens the foundation for precision medicine.
• Researchers conducted cross-ancestry analyses, uncovering novel disease associations in individuals of African and Asian descent, not just European populations.
September 8, 2025 at 7:32 PM
• Researchers conducted cross-ancestry analyses, uncovering novel disease associations in individuals of African and Asian descent, not just European populations.
🔍 For Scientists:
• This dataset captures coding and non-coding regions, structural variants, and rare mutations that older genotyping and exome sequencing methods often miss.
• This dataset captures coding and non-coding regions, structural variants, and rare mutations that older genotyping and exome sequencing methods often miss.
September 8, 2025 at 7:32 PM
🔍 For Scientists:
• This dataset captures coding and non-coding regions, structural variants, and rare mutations that older genotyping and exome sequencing methods often miss.
• This dataset captures coding and non-coding regions, structural variants, and rare mutations that older genotyping and exome sequencing methods often miss.
This isn’t just a technical milestone—it’s a leap forward in understanding how our genes influence health, disease, and treatment outcomes.
September 8, 2025 at 7:32 PM
This isn’t just a technical milestone—it’s a leap forward in understanding how our genes influence health, disease, and treatment outcomes.
🧬 A Landmark in Human Genomics—For Researchers and Everyone Else
The UK Biobank has just completed whole-genome sequencing for nearly half a million participants, creating one of the most comprehensive genetic datasets in the world.
The UK Biobank has just completed whole-genome sequencing for nearly half a million participants, creating one of the most comprehensive genetic datasets in the world.
September 8, 2025 at 7:32 PM
🧬 A Landmark in Human Genomics—For Researchers and Everyone Else
The UK Biobank has just completed whole-genome sequencing for nearly half a million participants, creating one of the most comprehensive genetic datasets in the world.
The UK Biobank has just completed whole-genome sequencing for nearly half a million participants, creating one of the most comprehensive genetic datasets in the world.
Proud to be part of an organization that supports these efforts with the tools and expertise needed to turn possibility into progress. Because rare diseases aren’t rare when they affect someone you care about—or someone just like Gunnar.
#KIF1A #nLorem #RareDisease #Cytiva #PatientStories #Genomics
#KIF1A #nLorem #RareDisease #Cytiva #PatientStories #Genomics
September 8, 2025 at 6:52 PM
Proud to be part of an organization that supports these efforts with the tools and expertise needed to turn possibility into progress. Because rare diseases aren’t rare when they affect someone you care about—or someone just like Gunnar.
#KIF1A #nLorem #RareDisease #Cytiva #PatientStories #Genomics
#KIF1A #nLorem #RareDisease #Cytiva #PatientStories #Genomics
Gunnar’s journey with KIF1A-associated neurological disorder is a powerful example of how personalized medicine can bring hope where options are few. The work that Cytiva and the n-Lorem Foundation are doing to develop a custom ASO therapy is nothing short of inspiring.
September 8, 2025 at 6:52 PM
Gunnar’s journey with KIF1A-associated neurological disorder is a powerful example of how personalized medicine can bring hope where options are few. The work that Cytiva and the n-Lorem Foundation are doing to develop a custom ASO therapy is nothing short of inspiring.
📌 Bottom Line: Exercise is essential, but like anything, balance matters. It is important to understand how the heart adapts to physical demands—and why recovery and monitoring are key for those pushing their limits. Read more here: lnkd.in/ecF5ta43
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September 6, 2025 at 7:04 PM
📌 Bottom Line: Exercise is essential, but like anything, balance matters. It is important to understand how the heart adapts to physical demands—and why recovery and monitoring are key for those pushing their limits. Read more here: lnkd.in/ecF5ta43
🧠 Why It Matters: Most heart research focuses on the left ventricle (the side that pumps blood to the body), but studies now show that the right ventricle also adapts—and sometimes struggles—under extreme physical stress.
September 6, 2025 at 7:04 PM
🧠 Why It Matters: Most heart research focuses on the left ventricle (the side that pumps blood to the body), but studies now show that the right ventricle also adapts—and sometimes struggles—under extreme physical stress.
This change isn’t necessarily harmful, but it raises questions about long-term effects in elite athletes.
September 6, 2025 at 7:04 PM
This change isn’t necessarily harmful, but it raises questions about long-term effects in elite athletes.
🔍 Key Takeaway: While exercise is great for heart health, extreme endurance efforts can cause the right ventricle to stretch and weaken temporarily, a phenomenon known as exercise-induced cardiac remodeling.
September 6, 2025 at 7:04 PM
🔍 Key Takeaway: While exercise is great for heart health, extreme endurance efforts can cause the right ventricle to stretch and weaken temporarily, a phenomenon known as exercise-induced cardiac remodeling.