@versteegga.bsky.social
We show that ERH and its associated RNA processing factors prevent intron retention in AU-rich regions of JAK2 transcripts. Loss of this regulation blocks JAK2 protein production and disrupts IFNγ signaling.
July 1, 2025 at 8:22 AM
We show that ERH and its associated RNA processing factors prevent intron retention in AU-rich regions of JAK2 transcripts. Loss of this regulation blocks JAK2 protein production and disrupts IFNγ signaling.
In great collaboration with the labs of @ameressl.bsky.social, Falk Butter, @reneketting.bsky.social, @mixmue.bsky.social, and @johanneszuber.bsky.social
July 1, 2025 at 8:22 AM
In great collaboration with the labs of @ameressl.bsky.social, Falk Butter, @reneketting.bsky.social, @mixmue.bsky.social, and @johanneszuber.bsky.social
Press release: bsky.app/profile/maxp...
🆕 publication! Cells don’t just fight infection - they fine-tune their immune response. A new study from the Versteeg lab in @narjournal.bsky.social led by Adrian Söderholm uncovers how RNA processing of JAK2 helps regulate immune signals ➡️ tinyurl.com/2py27c8u
@univie.ac.at
@meduniwien.ac.at
@univie.ac.at
@meduniwien.ac.at
July 1, 2025 at 8:22 AM
Press release: bsky.app/profile/maxp...
We uncover how TRIM52 helps protect genome integrity by limiting topoisomerase 2 damage — and how its own levels are controlled by a multi-ligase degradation system. www.nature.com/articles/s41.... www.maxperutzlabs.ac.at/news/latest-.... @maxperutzlabs.bsky.social @sfb-tpd-vienna.bsky.social
TRIM52 maintains cellular fitness and is under tight proteolytic control by multiple giant E3 ligases - Nature Communications
Despite not conserved in all mammals, TRIM52 is crucial for fitness in human cells. Here, the authors show that TRIM52 interacts with the DNA repair machinery to prevent cell-cycle arrest, and that TR...
www.nature.com
May 1, 2025 at 4:54 PM
We uncover how TRIM52 helps protect genome integrity by limiting topoisomerase 2 damage — and how its own levels are controlled by a multi-ligase degradation system. www.nature.com/articles/s41.... www.maxperutzlabs.ac.at/news/latest-.... @maxperutzlabs.bsky.social @sfb-tpd-vienna.bsky.social