Thanks so much for your kind words, Wolfgang!

Thank you so much!

Outstanding and fascinating… congratulations 👏

🌟 Interested in joining our team? We're hiring at all levels - from research technicians, MD and PhD students to postdocs. Contact: varun.venkataramani@med.uni-heidelberg.de 15/15

We are incredibly grateful for the patients, their families and the funding agencies for enabling this research!

Sonja Hänzelmann,
@matthiakarreman.bsky.social, Felix Kurz, Manuel Schröter, Marc Thieeir, Abigail Suwala, Karin Forsberg-Nilsson, Claudio Acuna,
@saezlab.bsky.social , Amir Abdollahi, Felix Sahm, Michael Breckwoldt, Bogdana Suchorska, Franz Ricklefs, Dieter Henrik Heiland

@atefehpourkhalili.bsky.social
@ninadrewa.bsky.social
@afaymonville.bsky.social
ville.bsky.social
@ekeifert.bsky.social
eifert.bsky.social, Julia Wagner,
@stellasoyka.bsky.social @marccschubert.bsky.social
@nirosansivapalan.bsky.social

So proud of the shared first authors
@ekinreyhan.bsky.social sky.social @svenjaktetzlaff.bsky.social etzlaff.bsky.social
and the entire team of amazing collaborators
@layern.bsky.social Peter Bengtson, Alina Heuer,
@julianschroers.bsky.social
@afaymonville.bsky.social

🔗 This research showcases the importance of bespoke methods development for Cancer Neuroscience, how it will advance our understanding of (brain) cancer circuits and the development of novel therapeutics for yet incurable tumors. 14/15

📊 Beyond just mapping, this work provides new therapeutic targets and a platform for testing treatments against these aggressive brain tumors. 13/15

🦠 Lastly, modified rabies viruses to disconnect tumor-connected neurons from brain tumor cells offer a potential novel therapeutic approach. 12/15

Tumor models of individual patients and distinct cell states showed heterogeneous patterns of neural connectivity. 11/15

💊 This led us to combine radiation with drugs that reduce neuronal activity. The combination proved more effective at treating tumors than either approach alone. 10/15

📡 Radiation therapy revealed something unexpected: It increased neuronal activity and subsequently connections between neurons and tumor cells. 9/15

🔍 A key discovery was the role of cholinergic neurons connected to glioblastoma cells: blocking their communication pathway slowed cortical tumor growth. 8/15