Varun Venkataramani
@venkataramanilab.bsky.social
Brain Tumor Researcher, Neurologist and Neuroscientist
#PhysicianScientist #CancerNeuroscience #DigitalHealth #AI #MethodsDevelopment
#PhysicianScientist #CancerNeuroscience #DigitalHealth #AI #MethodsDevelopment
🌟 Interested in joining our team? We're hiring at all levels - from research technicians, MD and PhD students to postdocs. Contact: varun.venkataramani@med.uni-heidelberg.de 15/15
December 6, 2024 at 11:18 PM
🌟 Interested in joining our team? We're hiring at all levels - from research technicians, MD and PhD students to postdocs. Contact: varun.venkataramani@med.uni-heidelberg.de 15/15
🦠 Lastly, modified rabies viruses to disconnect tumor-connected neurons from brain tumor cells offer a potential novel therapeutic approach. 12/15
December 6, 2024 at 11:18 PM
🦠 Lastly, modified rabies viruses to disconnect tumor-connected neurons from brain tumor cells offer a potential novel therapeutic approach. 12/15
Tumor models of individual patients and distinct cell states showed heterogeneous patterns of neural connectivity. 11/15
December 6, 2024 at 11:18 PM
Tumor models of individual patients and distinct cell states showed heterogeneous patterns of neural connectivity. 11/15
💊 This led us to combine radiation with drugs that reduce neuronal activity. The combination proved more effective at treating tumors than either approach alone. 10/15
December 6, 2024 at 11:18 PM
💊 This led us to combine radiation with drugs that reduce neuronal activity. The combination proved more effective at treating tumors than either approach alone. 10/15
🔍 A key discovery was the role of cholinergic neurons connected to glioblastoma cells: blocking their communication pathway slowed cortical tumor growth. 8/15
December 6, 2024 at 11:18 PM
🔍 A key discovery was the role of cholinergic neurons connected to glioblastoma cells: blocking their communication pathway slowed cortical tumor growth. 8/15
🧬 Using single-cell RNA sequencing and a functional neurotransmitter receptor screening, we found tumor cells express receptors for multiple neurotransmitters. This allows them to receive signals from many different types of neurons. 7/15
December 6, 2024 at 11:18 PM
🧬 Using single-cell RNA sequencing and a functional neurotransmitter receptor screening, we found tumor cells express receptors for multiple neurotransmitters. This allows them to receive signals from many different types of neurons. 7/15
🔭 Using advanced microscopy, we could visualize individual connections between neurons and tumor cells - providing direct evidence of these interactions, in particular cholinergic synapses. 6/15
December 6, 2024 at 11:18 PM
🔭 Using advanced microscopy, we could visualize individual connections between neurons and tumor cells - providing direct evidence of these interactions, in particular cholinergic synapses. 6/15
🌐 These weren't just local connections. The tumor cells established networks with neurons across different brain regions and even between hemispheres across large distances, showing remarkable integration. 5/15
December 6, 2024 at 11:18 PM
🌐 These weren't just local connections. The tumor cells established networks with neurons across different brain regions and even between hemispheres across large distances, showing remarkable integration. 5/15
⚡️ The timeline surprised us: Tumor cells formed functional connections with neurons very quickly with neurons within hours in culture and just days in the brain- much earlier than previously known and expected. 4/15
December 6, 2024 at 11:18 PM
⚡️ The timeline surprised us: Tumor cells formed functional connections with neurons very quickly with neurons within hours in culture and just days in the brain- much earlier than previously known and expected. 4/15
🔬 Our approach used the infection of tumor cells with a modified rabies virus that can only jump once to a directly connected neuron. When a neuron connects to a tumor cell, it lights up, creating a precise map of their connectome. 3/15
December 6, 2024 at 11:18 PM
🔬 Our approach used the infection of tumor cells with a modified rabies virus that can only jump once to a directly connected neuron. When a neuron connects to a tumor cell, it lights up, creating a precise map of their connectome. 3/15
🧪 How do brain tumors communicate with neurons? We developed a tracing system using modified rabies viruses to map these connections across the entire brain, revealing unexpected complexity. 2/15
December 6, 2024 at 11:18 PM
🧪 How do brain tumors communicate with neurons? We developed a tracing system using modified rabies viruses to map these connections across the entire brain, revealing unexpected complexity. 2/15
🧵Just in time for
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social
@svenjaktetzlaff.bsky.social
1/15
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social
@svenjaktetzlaff.bsky.social
1/15
December 6, 2024 at 11:18 PM
🧵Just in time for
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social
@svenjaktetzlaff.bsky.social
1/15
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social
@svenjaktetzlaff.bsky.social
1/15
🌟 Interested in joining our team? We're hiring at all levels - from research technicians, MD and PhD students to postdocs. Contact: varun.venkataramani@med.uni-heidelberg.de 15/15
December 6, 2024 at 10:47 PM
🌟 Interested in joining our team? We're hiring at all levels - from research technicians, MD and PhD students to postdocs. Contact: varun.venkataramani@med.uni-heidelberg.de 15/15
🦠 Lastly, modified rabies viruses to disconnect tumor-connected neurons from brain tumor cells offer a potential novel therapeutic approach. 12/15
December 6, 2024 at 10:47 PM
🦠 Lastly, modified rabies viruses to disconnect tumor-connected neurons from brain tumor cells offer a potential novel therapeutic approach. 12/15
Tumor models of individual patients and distinct cell states showed heterogeneous patterns of neural connectivity. 11/15
December 6, 2024 at 10:47 PM
Tumor models of individual patients and distinct cell states showed heterogeneous patterns of neural connectivity. 11/15
💊 This led us to combine radiation with drugs that reduce neuronal activity. The combination proved more effective at treating tumors than either approach alone. 10/15
December 6, 2024 at 10:47 PM
💊 This led us to combine radiation with drugs that reduce neuronal activity. The combination proved more effective at treating tumors than either approach alone. 10/15
🔍 A key discovery was the role of cholinergic neurons connected to glioblastoma cells: blocking their communication pathway slowed cortical tumor growth. 8/15
December 6, 2024 at 10:47 PM
🔍 A key discovery was the role of cholinergic neurons connected to glioblastoma cells: blocking their communication pathway slowed cortical tumor growth. 8/15
🧬 Using single-cell RNA sequencing and a functional neurotransmitter receptor screening, we found tumor cells express receptors for multiple neurotransmitters. This allows them to receive signals from many different types of neurons. 7/15
December 6, 2024 at 10:47 PM
🧬 Using single-cell RNA sequencing and a functional neurotransmitter receptor screening, we found tumor cells express receptors for multiple neurotransmitters. This allows them to receive signals from many different types of neurons. 7/15
🔭 Using advanced microscopy, we could visualize individual connections between neurons and tumor cells - providing direct evidence of these interactions, in particular cholinergic synapses. 6/15
December 6, 2024 at 10:47 PM
🔭 Using advanced microscopy, we could visualize individual connections between neurons and tumor cells - providing direct evidence of these interactions, in particular cholinergic synapses. 6/15
🌐 These weren't just local connections. The tumor cells established networks with neurons across different brain regions and even between hemispheres across large distances, showing remarkable integration. 5/15
December 6, 2024 at 10:47 PM
🌐 These weren't just local connections. The tumor cells established networks with neurons across different brain regions and even between hemispheres across large distances, showing remarkable integration. 5/15
⚡️ The timeline surprised us: Tumor cells formed functional connections with neurons very quickly with neurons within hours in culture and just days in the brain- much earlier than previously known and expected. 4/15
December 6, 2024 at 10:47 PM
⚡️ The timeline surprised us: Tumor cells formed functional connections with neurons very quickly with neurons within hours in culture and just days in the brain- much earlier than previously known and expected. 4/15
🔬 Our approach used the infection of tumor cells with a modified rabies virus that can only jump once to a directly connected neuron. When a neuron connects to a tumor cell, it lights up, creating a precise map of their connectome. 3/15
December 6, 2024 at 10:47 PM
🔬 Our approach used the infection of tumor cells with a modified rabies virus that can only jump once to a directly connected neuron. When a neuron connects to a tumor cell, it lights up, creating a precise map of their connectome. 3/15
🧪 How do brain tumors communicate with neurons? We developed a tracing system using modified rabies viruses to map these connections across the entire brain, revealing unexpected complexity. 2/15
December 6, 2024 at 10:47 PM
🧪 How do brain tumors communicate with neurons? We developed a tracing system using modified rabies viruses to map these connections across the entire brain, revealing unexpected complexity. 2/15
🧵Just in time for #FluorescenceFriday: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S... @ekinreyhan.bsky.social @svenjaktetzlaff.bsky.social
1/15
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S... @ekinreyhan.bsky.social @svenjaktetzlaff.bsky.social
1/15
December 6, 2024 at 10:47 PM
🧵Just in time for #FluorescenceFriday: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S... @ekinreyhan.bsky.social @svenjaktetzlaff.bsky.social
1/15
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S... @ekinreyhan.bsky.social @svenjaktetzlaff.bsky.social
1/15
The Venkataramani lab had an incredible time at #SNO2024! Very proud of Ekin Reyhan presenting our work during the Plenary Session, and so proud of Svenja Tetzlaff @svenjaktetzlaff.bsky.social & Julia Wagner for their poster presentations. Can’t wait for next year’s conference in Hawaii!
November 26, 2024 at 10:49 PM
The Venkataramani lab had an incredible time at #SNO2024! Very proud of Ekin Reyhan presenting our work during the Plenary Session, and so proud of Svenja Tetzlaff @svenjaktetzlaff.bsky.social & Julia Wagner for their poster presentations. Can’t wait for next year’s conference in Hawaii!