Powered for a 2.5% mortality difference, found point estimate 0.7%
Is aligned with MEGA-ROX (powered for a 1.5% - in progress)
Meanwhile there is much to unpick in discussion here at #CCR25 for these results …
Including overly pragmatic collection of safety outcome ?
3/3

Day 2 at #CCR25 & #UKROX
Is conservative O2 therapy in MV in ICU patients beneficial?
Ambitious #NIHR data-enabled trial & great example of how to do this.
3 data sources used for 16,500 patients in 97 sites with enhanced data for 15% for adherence
Great cast list!
1/3

Yes it does for PCT but no evidence for CRP to reduce antibiotic duration.
Fantastic editorial by @marionkcampbell.bsky.social to critique methods used and provide perspective on interpretation of secondary analysis explored regarding the strength of the PCT intervention

First up at #ccrdownunder24 ADAPTSepsis with Paul Dark Biomarker guided antibiotic duration in hospitalised patients with sepsis.
Does treatment protocol using CRP or PCT reduce total 28day use of antibiotics- and safely (28day mortality)?

All set for inaugural #ccrdownunder
4 major trial results coming up…

Arrived Melbourne and so excited for #CCRdownunder with some amazing trials and reviews ahead.
Always enjoy the in depth analysis and conversations unique to @criticalcarereviews.com