TRAUMOX2 trial: Comparing Restrictive vs. Liberal Oxygen Strategies in Trauma
In severely injured trauma patients, an early restrictive oxygen vs a liberal oxygen strategy did not reduce mortality and/or major respiratory complications.
#CCRdownunder
In severely injured trauma patients, an early restrictive oxygen vs a liberal oxygen strategy did not reduce mortality and/or major respiratory complications.
#CCRdownunder
December 10, 2024 at 10:26 PM
TRAUMOX2 trial: Comparing Restrictive vs. Liberal Oxygen Strategies in Trauma
In severely injured trauma patients, an early restrictive oxygen vs a liberal oxygen strategy did not reduce mortality and/or major respiratory complications.
#CCRdownunder
In severely injured trauma patients, an early restrictive oxygen vs a liberal oxygen strategy did not reduce mortality and/or major respiratory complications.
#CCRdownunder
JAMA Senior Editor Derek Angus, JAMA Associate Editor Christopher Seymour, and JAMA Editor in Chief Kirsten Bibbins-Domingo discuss 4 critical care trials published in JAMA and simultaneously presented at the 2024 #CCRdownunder
meeting.
ja.ma/3ORGQLH
meeting.
ja.ma/3ORGQLH
December 11, 2024 at 6:17 AM
JAMA Senior Editor Derek Angus, JAMA Associate Editor Christopher Seymour, and JAMA Editor in Chief Kirsten Bibbins-Domingo discuss 4 critical care trials published in JAMA and simultaneously presented at the 2024 #CCRdownunder
meeting.
ja.ma/3ORGQLH
meeting.
ja.ma/3ORGQLH
December 10, 2024 at 5:57 AM
High-flow nasal oxygen was noninferior to noninvasive ventilation for rates of endotracheal intubation or death within 7 days in 4 of the 5 patient groups with acute respiratory failure.
#CCRdownunder @criticalcarereviews.com
ja.ma/41s0Lbx
#CCRdownunder @criticalcarereviews.com
ja.ma/41s0Lbx
December 11, 2024 at 12:20 AM
High-flow nasal oxygen was noninferior to noninvasive ventilation for rates of endotracheal intubation or death within 7 days in 4 of the 5 patient groups with acute respiratory failure.
#CCRdownunder @criticalcarereviews.com
ja.ma/41s0Lbx
#CCRdownunder @criticalcarereviews.com
ja.ma/41s0Lbx
Quand même déçu par ce #CCRDownUnder...
December 11, 2024 at 2:07 PM
Quand même déçu par ce #CCRDownUnder...
Hello Bluesky! 🌛 Coming up tonight: Don't miss SAHaRA trial results, live from Melbourne! Catch the livestream using the link below at 11:30 p.m. Eastern Standard Time. #ccrdownunder
Less than 3 hours to #CCRdownunder in Melbourne
➡️ 8 major trial results over 2 days
➡️ In depth discussions
➡️ Full, free livestream
criticalcarereviews.com
➡️ 8 major trial results over 2 days
➡️ In depth discussions
➡️ Full, free livestream
criticalcarereviews.com
December 10, 2024 at 2:23 AM
Hello Bluesky! 🌛 Coming up tonight: Don't miss SAHaRA trial results, live from Melbourne! Catch the livestream using the link below at 11:30 p.m. Eastern Standard Time. #ccrdownunder
Paul Dark is presenting the results of ADAPT-SEPSIS - can CRP or PCT monitoring safely guide antibiotic duration in sepsis? Check out the livestream here: criticalcarereviews.com #ccrdownunder
Home
The most up-to-date critical care website in the world
criticalcarereviews.com
December 9, 2024 at 10:05 PM
Paul Dark is presenting the results of ADAPT-SEPSIS - can CRP or PCT monitoring safely guide antibiotic duration in sepsis? Check out the livestream here: criticalcarereviews.com #ccrdownunder
December 10, 2024 at 12:30 AM
Episode 57! We were excited to have Adam Wright, phD in Bioinformatics, to discuss SCREEN published by Arabi et al in JAMA 2024 and presented at #CCRDownUnder. A long episode but a lot of good discussion
SCREEN: pubmed.ncbi.nlm.nih.gov/39658862/
Listen anywhere: pod.link/1667336877
SCREEN: pubmed.ncbi.nlm.nih.gov/39658862/
Listen anywhere: pod.link/1667336877
ICU Ed and Todd-Cast
Two critical care guys walk into a recording studio and breakdown intensive care trials both old and new! We'll also do deep dives on specific topics important to practicing intensive care medicine an...
pod.link
January 28, 2025 at 7:39 PM
Episode 57! We were excited to have Adam Wright, phD in Bioinformatics, to discuss SCREEN published by Arabi et al in JAMA 2024 and presented at #CCRDownUnder. A long episode but a lot of good discussion
SCREEN: pubmed.ncbi.nlm.nih.gov/39658862/
Listen anywhere: pod.link/1667336877
SCREEN: pubmed.ncbi.nlm.nih.gov/39658862/
Listen anywhere: pod.link/1667336877
Aneurysmal SubArachnoid Hemorrhage - Red Blood Cell & Outcome (SAHaRA)
No stat significant primary outcome difference between the 2 groups. (Hb trigger ≤100g/L vs ≤80g/L respectively)
#CCRdownunder
No stat significant primary outcome difference between the 2 groups. (Hb trigger ≤100g/L vs ≤80g/L respectively)
#CCRdownunder
December 10, 2024 at 5:04 AM
Aneurysmal SubArachnoid Hemorrhage - Red Blood Cell & Outcome (SAHaRA)
No stat significant primary outcome difference between the 2 groups. (Hb trigger ≤100g/L vs ≤80g/L respectively)
#CCRdownunder
No stat significant primary outcome difference between the 2 groups. (Hb trigger ≤100g/L vs ≤80g/L respectively)
#CCRdownunder
Following on from the VACIRiSS Trial at the recent CCR down under, and the use of immune adjuvants ...maybe the post septic adult is the wrong target population
#CCRdownunder@criticalcarereviews.com
#CCRdownunder@criticalcarereviews.com
December 13, 2024 at 9:14 AM
Following on from the VACIRiSS Trial at the recent CCR down under, and the use of immune adjuvants ...maybe the post septic adult is the wrong target population
#CCRdownunder@criticalcarereviews.com
#CCRdownunder@criticalcarereviews.com
N=214 randomised
🎯 no effects for time to first infection-reated rehospitalisation
#CCRdownunder
#CCRdownunder24
🎯 no effects for time to first infection-reated rehospitalisation
#CCRdownunder
#CCRdownunder24
December 10, 2024 at 12:24 AM
N=214 randomised
🎯 no effects for time to first infection-reated rehospitalisation
#CCRdownunder
#CCRdownunder24
🎯 no effects for time to first infection-reated rehospitalisation
#CCRdownunder
#CCRdownunder24
We have seen a number of trials with non-significant findings at #CCRdownunder. There is often debate then about what next? This paper by Pocock & Stone is a useful discussion piece to inform this type of discussion
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
The Primary Outcome Fails — What Next? | NEJM
When the primary outcome of a clinical trial fails to reach its prespecified end point, can any clinically meaningful information still be derived from it? This review article addresses that question.
www.nejm.org
December 10, 2024 at 11:20 PM
We have seen a number of trials with non-significant findings at #CCRdownunder. There is often debate then about what next? This paper by Pocock & Stone is a useful discussion piece to inform this type of discussion
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
10d antibiotics in ADAPT-SEPSIS seems like a lot - however duration is entire antibiotic course over 28days (to account for restarting abx after too early cessation, etc) #ccrdownunder
December 9, 2024 at 10:41 PM
10d antibiotics in ADAPT-SEPSIS seems like a lot - however duration is entire antibiotic course over 28days (to account for restarting abx after too early cessation, etc) #ccrdownunder
ADAPT-SEPSIS: “Care guided by measurement of PCT reduces antibiotic duration safely compared with standard care, but CRP does not. All-cause mortality for CRP was inconclusive.” #ccrdownunder
December 9, 2024 at 10:22 PM
ADAPT-SEPSIS: “Care guided by measurement of PCT reduces antibiotic duration safely compared with standard care, but CRP does not. All-cause mortality for CRP was inconclusive.” #ccrdownunder
Honoured to join a remarkable meeting with brilliant faculties at #CCRdownunder in Melbourne. Days filled with respect for clinical trials and thorough discussions on critical aspects. "I am the dumbest person in the room, and it should be." Thank you @criticalcarereviews.com #CCRfamily
December 12, 2024 at 10:40 PM
Honoured to join a remarkable meeting with brilliant faculties at #CCRdownunder in Melbourne. Days filled with respect for clinical trials and thorough discussions on critical aspects. "I am the dumbest person in the room, and it should be." Thank you @criticalcarereviews.com #CCRfamily
Interesting results from the ALBICS-AKI trial
@criticalcarereviews.com DownUnder
Giving 20% Albumin to complex Cardiac Sx pts did not decrease the incidence of AKI,
It in fact *increased* the risk of AKI
Enough to suggest against the use of 20% albumin after cardiac Sx.
#emimcc #ICU #CCRdownunder
@criticalcarereviews.com DownUnder
Giving 20% Albumin to complex Cardiac Sx pts did not decrease the incidence of AKI,
It in fact *increased* the risk of AKI
Enough to suggest against the use of 20% albumin after cardiac Sx.
#emimcc #ICU #CCRdownunder
December 10, 2024 at 7:43 AM
Interesting results from the ALBICS-AKI trial
@criticalcarereviews.com DownUnder
Giving 20% Albumin to complex Cardiac Sx pts did not decrease the incidence of AKI,
It in fact *increased* the risk of AKI
Enough to suggest against the use of 20% albumin after cardiac Sx.
#emimcc #ICU #CCRdownunder
@criticalcarereviews.com DownUnder
Giving 20% Albumin to complex Cardiac Sx pts did not decrease the incidence of AKI,
It in fact *increased* the risk of AKI
Enough to suggest against the use of 20% albumin after cardiac Sx.
#emimcc #ICU #CCRdownunder
Next trial at #CCRDownunder @criticalcarereviews.com
VACiRISS trial: www.guysandstthomasbrc.nihr.ac.uk/microsites/v...
Presented by Manu Shankar-Hari
In adult sepsis survivors, does PCV vs placebo improves the composite outcome of time to first hospitalisation or death in 365 days?
VACiRISS trial: www.guysandstthomasbrc.nihr.ac.uk/microsites/v...
Presented by Manu Shankar-Hari
In adult sepsis survivors, does PCV vs placebo improves the composite outcome of time to first hospitalisation or death in 365 days?
VACIRiSS Trial – Vaccination for Immune Recovery Following Sepsis
www.guysandstthomasbrc.nihr.ac.uk
December 10, 2024 at 1:17 AM
Next trial at #CCRDownunder @criticalcarereviews.com
VACiRISS trial: www.guysandstthomasbrc.nihr.ac.uk/microsites/v...
Presented by Manu Shankar-Hari
In adult sepsis survivors, does PCV vs placebo improves the composite outcome of time to first hospitalisation or death in 365 days?
VACiRISS trial: www.guysandstthomasbrc.nihr.ac.uk/microsites/v...
Presented by Manu Shankar-Hari
In adult sepsis survivors, does PCV vs placebo improves the composite outcome of time to first hospitalisation or death in 365 days?
Fantastic podcast covering the 4 trials presented at #CCRdownunder and simultaneously published in @jama.com
@kbibbinsdomingo.bsky.social (JAMA EiC) with Chris Seymour (CC editor) & Derek Angus (senior editor)
edhub.ama-assn.org/jn-learning/...
@kbibbinsdomingo.bsky.social (JAMA EiC) with Chris Seymour (CC editor) & Derek Angus (senior editor)
edhub.ama-assn.org/jn-learning/...
JAMA Research at Critical Care Reviews 2024 (CCR Down Under)
JAMA Senior Editor Derek Angus, MD, MPH, and JAMA Associate Editor Christopher Seymour, MD, MSc, discuss 4 critical care trials published in JAMA and simultaneously presented at the 2024 CCR Down Under meeting in Melbourne, Australia, with JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS.
edhub.ama-assn.org
December 11, 2024 at 4:57 AM
Fantastic podcast covering the 4 trials presented at #CCRdownunder and simultaneously published in @jama.com
@kbibbinsdomingo.bsky.social (JAMA EiC) with Chris Seymour (CC editor) & Derek Angus (senior editor)
edhub.ama-assn.org/jn-learning/...
@kbibbinsdomingo.bsky.social (JAMA EiC) with Chris Seymour (CC editor) & Derek Angus (senior editor)
edhub.ama-assn.org/jn-learning/...
ADAPT-Sepsis results from CCR Down Under.
Some discussion. re the significance of a 1-day reduction of abx usage.
#CCRdownunder
Some discussion. re the significance of a 1-day reduction of abx usage.
#CCRdownunder
December 9, 2024 at 10:56 PM
ADAPT-Sepsis results from CCR Down Under.
Some discussion. re the significance of a 1-day reduction of abx usage.
#CCRdownunder
Some discussion. re the significance of a 1-day reduction of abx usage.
#CCRdownunder
Some images of today's sessions from #CCRdownunder
December 10, 2024 at 6:39 AM
Some images of today's sessions from #CCRdownunder
December 10, 2024 at 5:59 AM
VACIRiSS results from CCR Down Under.
1ry outcome: Time to first infection-related rehospitalisation or death, within 365-days
2ry outcomes: Rehospitalisation, reinfections,rehospitalisation, and time to first antibiotic therapy in general practice
#CCRdownunder
1ry outcome: Time to first infection-related rehospitalisation or death, within 365-days
2ry outcomes: Rehospitalisation, reinfections,rehospitalisation, and time to first antibiotic therapy in general practice
#CCRdownunder
December 10, 2024 at 12:12 AM
VACIRiSS results from CCR Down Under.
1ry outcome: Time to first infection-related rehospitalisation or death, within 365-days
2ry outcomes: Rehospitalisation, reinfections,rehospitalisation, and time to first antibiotic therapy in general practice
#CCRdownunder
1ry outcome: Time to first infection-related rehospitalisation or death, within 365-days
2ry outcomes: Rehospitalisation, reinfections,rehospitalisation, and time to first antibiotic therapy in general practice
#CCRdownunder
A major take home from ADAPT-SEPSIS - docs aren’t as good at stopping antibiotics as we think we are… #ccrdownunder
December 9, 2024 at 10:44 PM
A major take home from ADAPT-SEPSIS - docs aren’t as good at stopping antibiotics as we think we are… #ccrdownunder