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vanderbiltcsb.bsky.social
Vanderbilt Center for Structural Biology
@vanderbiltcsb.bsky.social
85 followers 35 following 50 posts
Vanderbilt Center for Structural Biology - Research dedicated to determining the 3D structure of biological macromolecules at or near atomic resolution.
www.vanderbilt.edu/csb
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vanderbiltcsb.bsky.social
Kate Clowes Moster, of the Chuck Sanders lab, is the winner of the 2026 Dr. Anne Karpay Award in Structural Biology!
bit.ly/2026-karpay

@vubasicsciences.bsky.social @vanderbiltvicb.bsky.social @vandybiomed.bsky.social
November 14, 2025 at 1:57 PM
vanderbiltcsb.bsky.social
With a new collaboration called diffUSE, the @stephanieaw.bsky.social lab is helping to advance our understanding of protein motion, leading to a new paradigm in dynamic structural biology.
@vubasicsciences.bsky.social
medschool.vanderbilt.edu/basic-scienc...
September 26, 2025 at 2:30 PM
vanderbiltcsb.bsky.social
The external speakers are set and ready to navigate the intersection of #AI & #StructBio for the Bridging Atoms and Algorithms: A Symposium on AI and Structural Biology.
🗓️Tuesday & Wednesday, March 17–18, 2026
🏫Campus of Vanderbilt University
bit.ly/4ldBOaz
June 17, 2025 at 1:15 PM
vanderbiltcsb.bsky.social
New research from the Plate and Meiler labs offers promise for treatment-resistant cystic fibrosis patients.
1st author Eli McDonald has personal reasons for the research. Read more ...
medschool.vanderbilt.edu/basic-scienc...

@vubasicsciences.bsky.social @vanderbiltvicb.bsky.social
June 9, 2025 at 7:16 PM
vanderbiltcsb.bsky.social
Meet @prash-singh.bsky.social of the Iverson lab. He’s getting used to the spotlight from his recent @smartereveryday.bsky.social appearance. He’s still the down-to-earth Prash who is always ready to respond to the “call of duty."
bit.ly/prash2025
@vubasicsciences.bsky.social #cryoem #research
May 30, 2025 at 2:30 PM
vanderbiltcsb.bsky.social
Mark your calendar and spread the word ...
@vubasicsciences.bsky.social @vanderbiltvicb.bsky.social @vucellimaging.bsky.social @vandybiomed.bsky.social

#structuralbiology #AI #research #cryoem #cryoet #protein
May 21, 2025 at 2:32 PM
vanderbiltcsb.bsky.social
Dr. Rong Sun and members of the Qiangjun Zhou lab are redefining synaptic architecture using nanoblocks as key organizing units in the postsynaptic density. Read more ...
bit.ly/4jTKTFg

@vubasicsciences.bsky.social
May 9, 2025 at 1:05 PM
vanderbiltcsb.bsky.social
May 6, 2025 at 1:57 PM
vanderbiltcsb.bsky.social
Sanders lab Postdoc @drstefanski.bsky.social lab motto might be “a place for everything and everything in its place.” Outside the lab she likes to wreak a bit of havoc in Smashville! That is, when it doesn’t get in the way of a good book. Meet Katherine…@vubasicsciences.bsky.social
bit.ly/42yJzRY
April 28, 2025 at 11:56 AM
vanderbiltcsb.bsky.social
Here @cameronicohen.bsky.social dives into the new findings from the @dougkojetin.bsky.social & the John Yang labs ... "From activation to repression: decoding the impact of PPARγ ligands on ligand-binding domain conformation"
bit.ly/43P7xJG
@vubasicsciences.bsky.social @vanderbilt.edu
April 11, 2025 at 5:36 PM
vanderbiltcsb.bsky.social
⚓️It's VU Giving Week! Support the CSB and the Anne Karpay Award in Structural Biology! Your gift supports innovation and discovery across Vanderbilt. Every gift makes a difference! 🧪🔬
Give to the CSB: www.givecampus.com/campaigns/57...
Give to the Karpay Award: www.givecampus.com/campaigns/57...
April 7, 2025 at 2:12 PM
vanderbiltcsb.bsky.social
Have you read the new paper from the QiangjunZhou lab? They show that the postsynaptic density in excitatory synapses is organized into heterogeneous nanoblocks, revealing a new layer of synaptic complexity.
doi.org/10.1083/jcb.20
#cryoEM #biophysics #neuroscience
@vubasicsciences.bsky.social
March 31, 2025 at 1:10 PM
vanderbiltcsb.bsky.social
Meet Areetha D'Souza ...
vanderbilt.edu/csb/2025/03/...
https://vanderbilt.edu/csb/2025/03/21/csb-spotlight-areetha-dsouza-chazin-lab/
March 21, 2025 at 4:31 PM
vanderbiltcsb.bsky.social
💊 CSB researchers @dougkojetin.bsky.social and John Yang find how small changes in drug molecules can switch PPARγ, a key protein, between active and repressive states. The breakthrough could help design better treatments for metabolic diseases. #NMR #crystallography
bit.ly/41Gktif
a AF-2 surface differences between PPARγ LBD in the transcriptionally active conformation bound to agonist rosiglitazone and TRAP220/MED1 coactivator peptide (PDB 6ONJ) and repressive conformation bound to inverse agonist T0070907 and NCoR1 corepressor peptide (PDB 6ONI) peptides. Coactivator and corepressor peptides are shown in green and pink, respectively. Helical structural elements are noted (h3, h4, h5, h12) and residue names are called out. b Pi stacking between the polar T0070907 pyridyl group and three residues (His323, His449, and Tyr473) and a bridging water molecule form in the transcriptionally repressive conformation (PDB 6ONI). c Compound scaffold of parent molecules containing polar pyridyl (T0070907) and hydrophobic phenyl (GW9662) groups in relation to the polar benzamide group in ZINC5672437. d TR-FRET NCoR1 corepressor biochemical interaction assay (n = 3 biological replicates; mean ± s.e.m.). e Cellular luciferase transcriptional reporter assay in HEK293T cells treated with 10 µM compound (n = 4 biological replicates; mean ± s.e.m.). f Crystal structures showing the compound flipped binding modes in transcriptionally active vs. repressive conformations when bound to GW9662 (PDB 3B0R and 8FHE), T0070907 (PDB 6C1I and 6ONI), or ZINC5672437 (PDB 8FHF and 8FHE). g ZINC5672437 pi-stacking interaction in the repressive state (PDB 8FHE) where the benzamide replaces the bridging water in the T0070907-bound structure (PDB 6ONI). h 2D [1H,15N]-TROSY-HSQC NMR focused on Gly399 of 15N-labeled PPARγ LBD bound to GW9662, T0070907, or ZINC5672437 in the absence (solid lines) or presence (dashed lines) of NCoR1 corepressor peptide. i Data-informed design hypothesis to improve PPARγ inverse agonism. Doug Kojetin, Vanderbilt Biochemistry, Center for Structural Biology John Yang, Vanderbilt Chemistry, Center for Structural Biology
March 20, 2025 at 4:25 PM
vanderbiltcsb.bsky.social
CSB Spotlight: X-ray #Crystallography - Paving the way for ‘hypoallergen’ treatments against peanut allergies. Ben Spiller & collaborators recent work show how IgE antibodies’ structural, immunological & functional properties interact with peanut allergens.
bit.ly/3Xw1mWO
March 7, 2025 at 2:00 PM
vanderbiltcsb.bsky.social
The deadline for the Mentored Structural Biology of Human Pathogens (MSBIO-PATH) Summer Program is fast approaching! Feb 14! Apply now!
bit.ly/3EqURhi
February 10, 2025 at 1:46 PM
vanderbiltcsb.bsky.social
New work from the Ren lab: "Structures and mRNP remodeling mechanism of the TREX-2 complex."
Supported by the CSB CryoEm Facility and the VU Mass Spectrometry Research Center.
www.sciencedirect.com/science/arti...
@vubasicsciences.bsky.social
February 3, 2025 at 3:51 PM
vanderbiltcsb.bsky.social
Recent work from Ray Blind & collaborators suggests that multiple inositol phosphate species can dynamically regulate mTOR & mTORC1 by promoting a stable, more soluble active state of the kinase.
www.vanderbilt.edu/csb/2025/01/...
@vubasicsciences.bsky.social @cameronicohen.bsky.social
January 31, 2025 at 6:34 PM
vanderbiltcsb.bsky.social
Congratulations to Jenny Tran of the Breann Brown lab! The 2025 recipient of the Dr. Anne Karpay Award in Structural Biology!
@vubasicsciences.bsky.social
January 21, 2025 at 9:12 PM
vanderbiltcsb.bsky.social
🚨Pre-print alert! The Chuck Sanders lab has discovered compounds that modulate the affinity of membrane proteins for lipid rafts as well as raft formation.
🎉Congrats to 1st author Katherine Stefanski!
www.biorxiv.org/content/10.1...
@vubasicsciences.bsky.social
High-throughput screening approach to identify modulators of PMP22 raft affinity. Pipeline used to screen 24,000+ compounds that identified hits described here.
January 13, 2025 at 1:55 PM
vanderbiltcsb.bsky.social
Check out TOMOMAN, a MATLAB-based package developed by the @williamnwan.bsky.social lab to act as a wrapper for external packages, storing metadata and interfacing the various packages used in each step of cryo-ET preprocessing ... bit.ly/3W49zB4

#structuralbiology @cameronicohen.bsky.social
January 3, 2025 at 7:32 PM
vanderbiltcsb.bsky.social
PhD student Alexandra Schwartz & Professor Hassane Mchaourab published a methodological blueprint to describe the structure of cell membrane transporters in @pnas.org. Learn how the Spectroscopy and AI method provide a unique window into protein structure and a mechanism of action. 🧬🧶
bit.ly/4g6jE8n
December 5, 2024 at 11:08 PM
vanderbiltcsb.bsky.social
🥳 Congratulations to Jenny Tran of the Breann Brown lab on being chosen as the 2025 winner of the Dr. Anne Karpay Award in Structural Biology! 🎉
December 5, 2024 at 4:24 PM