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uoe-igc.bsky.social
Institute of Genetics and Cancer
@uoe-igc.bsky.social
400 followers 340 following 160 posts
Our mission is to improve the lives of people living with genetic disease and cancer through research.
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uoe-igc.bsky.social
Family was an important theme of two talks by @jorisveltman.bsky.social & Charlie Lees at our Inaugural Lecture Showcase, where they shared their research and career journeys so far. Thanks to everyone who attended!
@cmvm-edinburghuni.bsky.social
November 13, 2025 at 2:30 PM
uoe-igc.bsky.social
Congratulations @nsbenab.bsky.social and fellow experts joining the Independent Scientific Advisory Panel! 👏
@cmvm-edinburghuni.bsky.social
bcrt-uk.bsky.social Bone Cancer Research Trust @bcrt-uk.bsky.social · 1d
Last week, we welcomed eight incredible experts to our Independent Scientific Advisory Panel (ISAP) 🔬

We asked our new members: what does being part of ISAP mean to you?

Learn more about the panel: ow.ly/OBTO50XiWbj

#Research #UntilTheresACure less
A graphic with an orange hexagon background & quote in a burgundy text box. The text reads: “I’m proud to help accelerate progress and ensure the research funded delivers meaningful change for bone cancer patients.” – Professor Steven Clifford A graphic with an orange hexagon background & quote in a grey text box. The text reads: “It gives me the chance to ensure that all the hard work people do to raise money is used effectively and improves patients’ lives.” – Professor Paul Cool A graphic with an orange hexagon background & quote in a green text box. The text reads: “It gives me the opportunity to identify research projects that will improve patients’ quality of life.” - Professor Dominique Heymann A graphic with an orange hexagon background & quote in a grey text box. The text reads: “It’s inspiring to be involved in efforts that bring us closer to better treatments and new hope for patients.” - Dr Nezha Benabdallah
November 12, 2025 at 3:16 PM
Reposted by Institute of Genetics and Cancer
dev-journal.bsky.social
Neanderthal DNA enhances our understanding of face development

This Research Highlight showcases the work from Hannah Long @hannahlong.bsky.social, Kirsty Uttley @kirstyuttley.bsky.social, Hannah Jüllig @hannahjuellig.bsky.social and colleagues: journals.biologists.com/dev/article/...
November 10, 2025 at 1:04 PM
uoe-igc.bsky.social
🎺There are only a few tickets left for our inaugural lecture showcase tomorrow evening with @jorisveltman.bsky.social and Charlie Lees - so grab yours now! 🎫
@cmvm-edinburghuni.bsky.social
uoe-igc.bsky.social Institute of Genetics and Cancer @uoe-igc.bsky.social · 8d
Join us for our free inaugural lecture & drinks reception. @jorisveltman.bsky.social will talk about the genetic causes of rare disorders such as reproductive disorders & Charlie Lees will tell the 20‑year story of change in IBD.
More info & register👉 bit.ly/3J766hJ
@cmvm-edinburghuni.bsky.social
November 11, 2025 at 10:14 AM
uoe-igc.bsky.social
And read more about the researchers behind the paper in this interview in Development:
doi.org/10.1242/dev....
@biologists.bsky.social
November 10, 2025 at 12:15 PM
uoe-igc.bsky.social
Find out how the dark genome holds clues to Neanderthal face shape and how this could help in future research into human disease in this new study from IGC researchers 👉 edin.ac/443d1j4
@hannahlong.bsky.social
@kirstyuttley.bsky.social
@hannahjuellig.bsky.social
@cmvm-edinburghuni.bsky.social
Dark genome holds clues to Neanderthal face shape | Institute of Genetics and Cancer | Institute of Genetics and Cancer
Differences in a specific region of the Neanderthal genetic code may have contributed to their distinctive protruding jawline, a study suggests.
edin.ac
November 10, 2025 at 12:04 PM
uoe-igc.bsky.social
Congratulations to @wbickmor.bsky.social, @ceesdekker.bsky.social, Leonid Mirny and @benjaminrowland.bsky.social on this prestigious @erc.europa.eu Synergy Grant award for their GeneMotors project to understand how SMC motors work.
Read more here 👉 edin.ac/4qMbR5r
@cmvm-edinburghuni.bsky.social
November 7, 2025 at 2:28 PM
Reposted by Institute of Genetics and Cancer
onehealthgenomics.bsky.social
New Publication:

A methylome-wide association study of major depression with out-of-sample case–control classification and trans-ancestry comparison

@edinunineuro.bsky.social @uoe-igc.bsky.social @roslininstitute.bsky.social @edinunilbc.bsky.social

www.nature.com/articles/s44...
A methylome-wide association study of major depression with out-of-sample case–control classification and trans-ancestry comparison - Nature Mental Health
The authors report a meta-analysis of methylome-wide association studies, identifying 15 significant CpG sites linked to major depression, revealing associations with inflammatory markers and suggesti...
www.nature.com
November 6, 2025 at 4:28 PM
uoe-igc.bsky.social
An international trial led by researchers at IGC and @nkinl.bsky.social has found that radiotherapy can be safely omitted as a treatment for many breast cancer patients who have had a mastectomy and are taking anti-cancer drugs. Read more here👉https://edin.ac/3JIQfpL
@cmvm-edinburghuni.bsky.social
November 6, 2025 at 10:50 AM
uoe-igc.bsky.social
Join us for our free inaugural lecture & drinks reception. @jorisveltman.bsky.social will talk about the genetic causes of rare disorders such as reproductive disorders & Charlie Lees will tell the 20‑year story of change in IBD.
More info & register👉 bit.ly/3J766hJ
@cmvm-edinburghuni.bsky.social
November 5, 2025 at 10:28 AM
Reposted by Institute of Genetics and Cancer
cruk-si.bsky.social
📢 Applications for the Black Leaders in Cancer PhD programme in Scotland are now open!

The programme offers a unique opportunity for students from Black heritage backgrounds to pursue a fully funded 4-year PhD.

👉Apply by 24 November 2025: www.crukscotlandcentre.ac.uk/training/phd-studentships
November 3, 2025 at 1:48 PM
Reposted by Institute of Genetics and Cancer
onehealthgenomics.bsky.social
New Publication:

Genome-Wide Aggregated Trans Effects Analysis for Circulating Proteins Indicates a Key Role of Immune Checkpoints in Type 1 Diabetes

@uoe-igc.bsky.social

diabetesjournals.org/diabetes/art...
Genome-Wide Aggregated Trans Effects Analysis for Circulating Proteins Indicates a Key Role of Immune Checkpoints in Type 1 Diabetes
The “omnigenic” hypothesis postulates that polygenic effects of common variants on typical complex traits coalesce via trans effects on the expression of a
diabetesjournals.org
October 31, 2025 at 3:52 PM
uoe-igc.bsky.social
Happy Hallowe'en from everyone at the IGC! @modelzebrafish.bsky.social
October 31, 2025 at 3:31 PM
Reposted by Institute of Genetics and Cancer
fengfishlab.bsky.social
Hot off the press, after years of work by many PG and undergrads and collaborators, we present you wilth a detailed analysis of oncogenic RAS driven cellular plasticity and host immune response within 24 hours of oncogene activation in a #zebrafish model www.cell.com/cell-reports...
Oncogenic Ras activation in permissive somatic cells triggers rapid-onset phenotypic plasticity and elicits a tumor-promoting neutrophil response
Ras mutations drive tumorigenesis yet persist in normal tissues. Elliot et al. explore this paradox, finding that HRASG12V induces bifurcating cell fates in the zebrafish larval epidermis, with lamc2+...
www.cell.com
October 29, 2025 at 5:01 PM
uoe-igc.bsky.social
Research led by Roza Masalmeh and Margaret Frame into focal adhesion kinase (FAK), a key protein behind the spread of cancer cells in the aggressive brain cancer glioblastoma, has found it also boosts how they make energy 👉
Targeting a key adhesion protein renders glioblastoma cells energetically sluggish, suppressing growth and invasion | Institute of Genetics and Cancer | Institute of Genetics and Cancer
Research into focal adhesion kinase (FAK), a key protein behind the spread of cancer cells, has found it also boosts how they make energy.
institute-genetics-cancer.ed.ac.uk
October 17, 2025 at 12:17 PM
uoe-igc.bsky.social
"...research isn’t just about data and discoveries; it’s about people, perspectives, and the places that inspire us."
@sunandan.bsky.social from @iimcb.bsky.social has written about his experience of visiting Edinburgh and #IGC for a two-week research visit 👉
Science, Stories and Stone: My Research Journey in Edinburgh – Institute of Genetics and Cancer
A blog for our community to write about their interests and to share their stories.
edin.ac
October 17, 2025 at 9:45 AM
uoe-igc.bsky.social
IGC Director @jorisveltman.bsky.social and Professor of Gastroenterology Charlie Lees will share their careers and research journeys so far at an Inaugural Showcase:

📍 Lecture Theatre, Institute of Genetics and Cancer

📅 Wednesday 12 November

⏰ 5-7:30pm

Register for free here: bit.ly/3J766hJ
October 16, 2025 at 11:13 AM
Reposted by Institute of Genetics and Cancer
humanimaltrust.bsky.social
We’re excited to share an incredible opportunity to join the team delivering our first major cancer research project, as a Postdoctoral Research Associate (PDRA).

📍 Easter Bush Campus, @edinburghuni.bsky.social
🗓️ Closing date: 27 October 2025
🔗 Find out more and apply: bit.ly/4nrooZj
October 16, 2025 at 7:41 AM
uoe-igc.bsky.social
Only a week left for health professionals to apply for the Edinburgh Clinical Academic Track (ECAT-i) programme with NES & @nhslothian.bsky.social. Apply by 22 Oct: edin.ac/3IqZFG2
Read more about the experience of previous and current ECAT participants here 👉 edin.ac/3J9H8OG
ECAT-i Clinical Lectureships Med Surg GP 2026 intake
We are seeking to appoint up to five highly ambitious individuals who wish to undertake a PhD and who aspire to become the next generation of clinical academic leaders.
edin.ac
October 15, 2025 at 10:24 AM
uoe-igc.bsky.social
#ALD25 marks the life & work of Ada Lovelace and highlights the achievements of women in #STEM. IGC's @lmluque.bsky.social honours her contribution and calls for space to be given to all female scientists to build the greenhouse their ideas deserve: 👉 edin.ac/47oCc1B
@cmvm-edinburghuni.bsky.social
October 14, 2025 at 1:30 PM
Reposted by Institute of Genetics and Cancer
onehealthgenomics.bsky.social
New Publication:

Assessing variant effect predictors and disease mechanisms in intrinsically disordered proteins

@uoe-igc.bsky.social @jmarshlab.bsky.social

journals.plos.org/ploscompbiol...
Assessing variant effect predictors and disease mechanisms in intrinsically disordered proteins
Author summary Some parts of proteins, known as intrinsically disordered regions, do not fold into fixed shapes. Instead, they stay flexible and play key roles in controlling how cells work, often by ...
journals.plos.org
October 13, 2025 at 3:45 PM
uoe-igc.bsky.social
"I love genetics because it allows us to get to the root cause, the earliest initiating mechanisms in disease. And I love clinical work because our patients are so inspiring."
Read the interview with Prof Sara Brown in @emjreviews.bsky.social about her eczema research: edin.ac/3J3ZaSj
Gene–Environment Interactions in Dermatology: Interview with Sara J. Brown
Discover groundbreaking eczema research with Sara J. Brown, exploring skin organoids, genetics, and future breakthroughs in dermatology...
edin.ac
October 13, 2025 at 10:39 AM
uoe-igc.bsky.social
"I brought back both technical know-how and a new perspective. Thanks to my time in Edinburgh, I now know how to handle the protein under specific conditions and avoid pitfalls." Yun-Hsuan Huang on her @mdc-berlin.bsky.social placement in @chromatinlab.bsky.social.
Read more here 👉 edin.ac/3IFDLyY
October 13, 2025 at 7:41 AM
Reposted by Institute of Genetics and Cancer
onehealthgenomics.bsky.social
#GettingGenomeMe Genomics Researcher Profile

Find out about PhD Student Aleksandra Chybowska who is working on next-generation sequencing in epigenetic epidemiology with Professor Riccardo Marioni's Group at IGC.

@uoe-igc.bsky.social

onehealthgenomics.ed.ac.uk/Aleksandra-C...
Aleksandra Chybowska on using biomarkers to predict cardiovascular disease | One Health Genomics Edinburgh | Genomics
Aleksandra Chybowska is a PhD student in Professor Riccardo Marioni’s group at the Institute of Genetics and Cancer. Here she talks about working on next-generation sequencing in epigenetic epidemiolo...
onehealthgenomics.ed.ac.uk
October 10, 2025 at 11:01 AM
Reposted by Institute of Genetics and Cancer
onehealthgenomics.bsky.social
New Publication:

Role of RNA in genome folding: It's all about affinity

@uoe-igc.bsky.social @drrafalczapiewski.bsky.social

www.sciencedirect.com/science/arti...
Role of RNA in genome folding: It's all about affinity
In mammalian cells, RNA species make up ∼10% of chromatin by mass and play a structural role in the nucleus by acting as scaffolds and influencing gen…
www.sciencedirect.com
October 10, 2025 at 10:40 AM