Centre for Muscle Research (CMR)
@unimelbcmr.bsky.social
Advancing muscle biology and its importance in health and disease. #myoblue #sarcopenia #myology #skeletalmuscle #musculoskeletal #neuromuscular #cachexia
http://unimelb.edu.au/muscle-research
http://unimelb.edu.au/muscle-research
Congrats to the CMR's Alastair Saunders, Paul Gregorevic and Team for their new AJPCellPhys paper "Cachexia progression differs among mouse models of metastatic triple-negative breast cancer"
#Cancer #cachexia
journals.physiology.org/doi/full/10....
#Cancer #cachexia
journals.physiology.org/doi/full/10....
Cachexia progression differs among mouse models of metastatic triple-negative breast cancer | American Journal of Physiology-Cell Physiology | American Physiological Society
Cancer-associated cachexia decreases the quality of life, reduces therapy response, and diminishes survival prospects. Effective cachexia countermeasures remain a significant unmet need. Research into...
journals.physiology.org
October 25, 2025 at 6:04 PM
Congrats to the CMR's Alastair Saunders, Paul Gregorevic and Team for their new AJPCellPhys paper "Cachexia progression differs among mouse models of metastatic triple-negative breast cancer"
#Cancer #cachexia
journals.physiology.org/doi/full/10....
#Cancer #cachexia
journals.physiology.org/doi/full/10....
Congrats to Dr Yasmine Ali Abdelhamid, Prof Adam Deane & Team for their new paper on the effect of enteral glycine in critically ill patients, that also involved the CMR's Amy Bongetti, @CaldowMarissa and @GordonSLynch
www.clinicalnutritionjournal.com/article/S0261-5614(25)00271-7/
www.clinicalnutritionjournal.com/article/S0261-5614(25)00271-7/
The effect of enteral glycine on plasma glycine and muscle structure, size, and function in the critically ill: A randomized controlled trial
Critically ill patients frequently experience severe muscle loss with subsequent physical
impairment. In pre-clinical models of muscle wasting, administration of the amino
acid glycine attenuates musc...
www.clinicalnutritionjournal.com
October 19, 2025 at 6:21 PM
Congrats to Dr Yasmine Ali Abdelhamid, Prof Adam Deane & Team for their new paper on the effect of enteral glycine in critically ill patients, that also involved the CMR's Amy Bongetti, @CaldowMarissa and @GordonSLynch
www.clinicalnutritionjournal.com/article/S0261-5614(25)00271-7/
www.clinicalnutritionjournal.com/article/S0261-5614(25)00271-7/
Checkout the new paper from @hughesdc-muscle.bsky.social & Team, which also involved the CMR's @craigagoodman1.bsky.social
Response of UBR-box E3 ubiquitin ligases & protein quality control pathways to perturbations in protein synthesis & skeletal muscle size
journals.physiology.org/doi/abs/10.1...
Response of UBR-box E3 ubiquitin ligases & protein quality control pathways to perturbations in protein synthesis & skeletal muscle size
journals.physiology.org/doi/abs/10.1...
Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size | American Journal of Physiology-Cell Physiology | American...
The N-degron pathway contributes to proteolysis by targeting N-terminal residues of destabilized proteins via E3 ligases that contain a UBR-box domain. Emerging evidence suggests the UBR-box family of...
journals.physiology.org
October 14, 2025 at 6:35 PM
Checkout the new paper from @hughesdc-muscle.bsky.social & Team, which also involved the CMR's @craigagoodman1.bsky.social
Response of UBR-box E3 ubiquitin ligases & protein quality control pathways to perturbations in protein synthesis & skeletal muscle size
journals.physiology.org/doi/abs/10.1...
Response of UBR-box E3 ubiquitin ligases & protein quality control pathways to perturbations in protein synthesis & skeletal muscle size
journals.physiology.org/doi/abs/10.1...
Congratulations to the CMR's @kristyswid.bsky.social and Prof Gordon Lynch for their new review paper on "Translational progress in the development of pharmacotherapies for Duchenne muscular dystrophy"
www.tandfonline.com/doi/full/10....
@mda.org
www.tandfonline.com/doi/full/10....
@mda.org
Translational progress in the development of pharmacotherapies for Duchenne muscular dystrophy
Despite the discovery, nearly 40 years ago, that mutations in the dystrophin gene were responsible for Duchenne muscular dystrophy (DMD), a cure for this devastating disease remains elusive. Consid...
www.tandfonline.com
October 9, 2025 at 6:03 PM
Congratulations to the CMR's @kristyswid.bsky.social and Prof Gordon Lynch for their new review paper on "Translational progress in the development of pharmacotherapies for Duchenne muscular dystrophy"
www.tandfonline.com/doi/full/10....
@mda.org
www.tandfonline.com/doi/full/10....
@mda.org
Congratulations to CMR PhD student, John Nguyen, on receiving a @aegeanconf.bsky.social Trainee Award at the 6th International Conference on Stem Cells, in Sissi, Crete, Greece.
#muscle #Myotwitter #stemcells #regeneration #metabolism #physiology
#muscle #Myotwitter #stemcells #regeneration #metabolism #physiology
October 9, 2025 at 9:00 AM
Congratulations to CMR PhD student, John Nguyen, on receiving a @aegeanconf.bsky.social Trainee Award at the 6th International Conference on Stem Cells, in Sissi, Crete, Greece.
#muscle #Myotwitter #stemcells #regeneration #metabolism #physiology
#muscle #Myotwitter #stemcells #regeneration #metabolism #physiology
Congratulations to John Nguyen on a successful PhD oration: ‘Metabolic control of skeletal muscle regeneration’. Now for the thesis!
Supervisors: Prof Gordon Lynch, @kristyswid.bsky.social, Assoc Prof Kristin Brown, @craigagoodman1.bsky.social
#muscle #stemcells #regeneration #injury #metabolism
Supervisors: Prof Gordon Lynch, @kristyswid.bsky.social, Assoc Prof Kristin Brown, @craigagoodman1.bsky.social
#muscle #stemcells #regeneration #injury #metabolism
September 22, 2025 at 8:13 PM
Congratulations to John Nguyen on a successful PhD oration: ‘Metabolic control of skeletal muscle regeneration’. Now for the thesis!
Supervisors: Prof Gordon Lynch, @kristyswid.bsky.social, Assoc Prof Kristin Brown, @craigagoodman1.bsky.social
#muscle #stemcells #regeneration #injury #metabolism
Supervisors: Prof Gordon Lynch, @kristyswid.bsky.social, Assoc Prof Kristin Brown, @craigagoodman1.bsky.social
#muscle #stemcells #regeneration #injury #metabolism
The CMR gathers wearing green to celebrate International Myotonic Dystrophy Awareness Day to promote research & funding to improve the lives of those affected by DM, a neuromuscular disease causing progressive muscle weakness
@mda.org @myotonicstrong.bsky.social #muscle
@mda.org @myotonicstrong.bsky.social #muscle
September 15, 2025 at 2:13 AM
The CMR gathers wearing green to celebrate International Myotonic Dystrophy Awareness Day to promote research & funding to improve the lives of those affected by DM, a neuromuscular disease causing progressive muscle weakness
@mda.org @myotonicstrong.bsky.social #muscle
@mda.org @myotonicstrong.bsky.social #muscle
The CMR is on a mission to understand and treat DMD and other neuromuscular disorders. We remain deeply committed to, and passionately support, #WDAD2025
#muscle #Duchenne #dystrophy #muscular
#muscle #Duchenne #dystrophy #muscular
September 7, 2025 at 12:11 AM
The CMR is on a mission to understand and treat DMD and other neuromuscular disorders. We remain deeply committed to, and passionately support, #WDAD2025
#muscle #Duchenne #dystrophy #muscular
#muscle #Duchenne #dystrophy #muscular
Congrats to Steffen Raun, Lykke Sylow and Team for their new Redox Biology paper, "Skeletal muscle Rac1 mediates exercise training adaptations towards muscle glycogen resynthesis and protein synthesis", that included the CMR's Prof Paul Gregorevic
www.sciencedirect.com/science/arti...
Congrats to Steffen Raun, Lykke Sylow and Team for their new Redox Biology paper, "Skeletal muscle Rac1 mediates exercise training adaptations towards muscle glycogen resynthesis and protein synthesis", that included the CMR's Prof Paul Gregorevic
www.sciencedirect.com/science/arti...
Skeletal muscle Rac1 mediates exercise training adaptations towards muscle glycogen resynthesis and protein synthesis
Long-term exercise training elicits tremendous health benefits; however, the molecular understanding is incomplete and identifying therapeutic targets…
www.sciencedirect.com
August 30, 2025 at 10:09 PM
Congrats to Steffen Raun, Lykke Sylow and Team for their new Redox Biology paper, "Skeletal muscle Rac1 mediates exercise training adaptations towards muscle glycogen resynthesis and protein synthesis", that included the CMR's Prof Paul Gregorevic
www.sciencedirect.com/science/arti...
Congrats to Steffen Raun, Lykke Sylow and Team for their new Redox Biology paper, "Skeletal muscle Rac1 mediates exercise training adaptations towards muscle glycogen resynthesis and protein synthesis", that included the CMR's Prof Paul Gregorevic
www.sciencedirect.com/science/arti...
Congrats to Sebastian BassStringer, Prof Juli McMullen & Team for their new paper "Generation and evaluation of a novel PI3K-targeting gene therapy in the failing mouse heart and healthy sheep heart", that included the CMR's Prof Paul Gregorevic
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Generation and evaluation of a novel PI3K-targeting gene therapy in the failing mouse heart and healthy sheep heart
Heart failure (HF) remains a clinical challenge with cardiac dysfunction typically progressing even with treatment, and heart transplants only availab…
www.sciencedirect.com
August 21, 2025 at 8:05 PM
Congrats to Sebastian BassStringer, Prof Juli McMullen & Team for their new paper "Generation and evaluation of a novel PI3K-targeting gene therapy in the failing mouse heart and healthy sheep heart", that included the CMR's Prof Paul Gregorevic
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Congratulations to Kevin (Yansong) Lu & Prof Pete Currie of the Australian Regenerative Medicine Institute (ARMI), and the CMR's Dr Avnika Ruparelia, for their new review paper, "Zebrafish: Lessons and Insights into Skeletal Muscle Research"
cshperspectives.cshlp.org/content/earl...
cshperspectives.cshlp.org/content/earl...
Zebrafish: Lessons and Insights into Skeletal Muscle Research
A new type of review journal, featuring comprehensive collections of expert review articles on important topics in the molecular life sciences
cshperspectives.cshlp.org
August 7, 2025 at 11:27 PM
Congratulations to Kevin (Yansong) Lu & Prof Pete Currie of the Australian Regenerative Medicine Institute (ARMI), and the CMR's Dr Avnika Ruparelia, for their new review paper, "Zebrafish: Lessons and Insights into Skeletal Muscle Research"
cshperspectives.cshlp.org/content/earl...
cshperspectives.cshlp.org/content/earl...
Check out the new post-doc opportunity in the Lab of Prof Matt Watt, in collaboration with an industry partner, on muscle signalling and metabolism related to metabolic disease and future obesity treatments
unimelb.wd105.myworkdayjobs.com/UoM_External...
unimelb.wd105.myworkdayjobs.com/UoM_External...
Research Fellow in Muscle Signalling and Metabolism
Role type: Full time, fixed term position for 24 months Faculty: Medicine, Dentistry and Health Sciences Department/School: Anatomy and Physiology Salary: Level A – $108,156 - $116,094 p.a. plus 17% s...
unimelb.wd105.myworkdayjobs.com
July 31, 2025 at 9:30 PM
Check out the new post-doc opportunity in the Lab of Prof Matt Watt, in collaboration with an industry partner, on muscle signalling and metabolism related to metabolic disease and future obesity treatments
unimelb.wd105.myworkdayjobs.com/UoM_External...
unimelb.wd105.myworkdayjobs.com/UoM_External...
Reposted by Centre for Muscle Research (CMR)
It's time to register for the 2025 Victorian Muscle Network Symposium! 🚨
Please register now: victorianmusclenetwork.wordpress.com
🗓️Make sure to register by the 14th of September
👀 Keynote speakers to be confirmed soon
Please register now: victorianmusclenetwork.wordpress.com
🗓️Make sure to register by the 14th of September
👀 Keynote speakers to be confirmed soon
July 28, 2025 at 12:33 AM
It's time to register for the 2025 Victorian Muscle Network Symposium! 🚨
Please register now: victorianmusclenetwork.wordpress.com
🗓️Make sure to register by the 14th of September
👀 Keynote speakers to be confirmed soon
Please register now: victorianmusclenetwork.wordpress.com
🗓️Make sure to register by the 14th of September
👀 Keynote speakers to be confirmed soon
Congrats to Bryan Remaily, Chris Coss, Mitch Phelps, and Team, for their new JCSM Commications paper "Intramuscular CMT-167 Tumours Produce a Mild Cachexia Phenotype in C57BL/6J Mice", that included the CMR's Prof Paul Gregorevic
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Intramuscular CMT‐167 Tumours Produce a Mild Cachexia Phenotype in C57BL/6J Mice
Background Cancer cachexia is a debilitating syndrome characterized by irreversible losses in skeletal muscle mass, with or without losses in adipose tissue. Cancer cachexia is an underrecognized sy...
onlinelibrary.wiley.com
July 15, 2025 at 9:40 PM
Congrats to Bryan Remaily, Chris Coss, Mitch Phelps, and Team, for their new JCSM Commications paper "Intramuscular CMT-167 Tumours Produce a Mild Cachexia Phenotype in C57BL/6J Mice", that included the CMR's Prof Paul Gregorevic
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
The CMR recognises #WorldSarcopeniaDay.
Interrogating ways to preserve muscle function as we age is a major theme of study in the CMR & our researchers continue to make contributions to the field.
#Myotwitter #sarcopenia #aging #longevity #health #exercise
Interrogating ways to preserve muscle function as we age is a major theme of study in the CMR & our researchers continue to make contributions to the field.
#Myotwitter #sarcopenia #aging #longevity #health #exercise
July 4, 2025 at 2:12 AM
The CMR recognises #WorldSarcopeniaDay.
Interrogating ways to preserve muscle function as we age is a major theme of study in the CMR & our researchers continue to make contributions to the field.
#Myotwitter #sarcopenia #aging #longevity #health #exercise
Interrogating ways to preserve muscle function as we age is a major theme of study in the CMR & our researchers continue to make contributions to the field.
#Myotwitter #sarcopenia #aging #longevity #health #exercise
Checkout the new review paper from the CMR's Julian Wong, Yaan-Kit Ng, Ronnie Blazev & @benparkerlab.bsky.social & the NNF CBMR's Jeppe Kjærgaard & @adeshmukh.bsky.social on Skeletal Muscle Proteomics: Considerations and Opportunities.
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Skeletal muscle proteomics: considerations and opportunities - npj Metabolic Health and Disease
npj Metabolic Health and Disease - Skeletal muscle proteomics: considerations and opportunities
www.nature.com
July 3, 2025 at 7:40 PM
Checkout the new review paper from the CMR's Julian Wong, Yaan-Kit Ng, Ronnie Blazev & @benparkerlab.bsky.social & the NNF CBMR's Jeppe Kjærgaard & @adeshmukh.bsky.social on Skeletal Muscle Proteomics: Considerations and Opportunities.
www.nature.com/articles/s44...
www.nature.com/articles/s44...
Congratulations to Amy Bongetti, Dr Marissa Caldow, Dr Yasmine Ali Abdelhamid and Prof Gordon Lynch for their new review paper, "Evaluating skeletal muscle wasting and weakness in models of critical illness".
#muscle #ICU
portlandpress.com/clinsci/arti...
#muscle #ICU
portlandpress.com/clinsci/arti...
Evaluating skeletal muscle wasting and weakness in models of critical illness
Skeletal muscle wasting and weakness are common complications associated with admission to the intensive care unit (ICU), with the loss of muscle mass and function increasing mortality and contributin...
portlandpress.com
July 2, 2025 at 7:42 PM
Congratulations to Amy Bongetti, Dr Marissa Caldow, Dr Yasmine Ali Abdelhamid and Prof Gordon Lynch for their new review paper, "Evaluating skeletal muscle wasting and weakness in models of critical illness".
#muscle #ICU
portlandpress.com/clinsci/arti...
#muscle #ICU
portlandpress.com/clinsci/arti...
Congratulations to Lee-Anne Chapple,the CMR's Gordon Lynch and Olav Rooyackers for their new review on "Impaired muscle metabolism in the ICU: interrogating the underlying pathophysiology".
journals.lww.com/co-criticalc...
journals.lww.com/co-criticalc...
Impaired muscle metabolism in the ICU: interrogating the... : Current Opinion in Critical Care
lled trials in critically ill adults have reported signals of harm from higher protein administration compared to lower protein doses or standard of care, with significant results pertaining to reduce...
journals.lww.com
June 20, 2025 at 11:23 PM
Congratulations to Lee-Anne Chapple,the CMR's Gordon Lynch and Olav Rooyackers for their new review on "Impaired muscle metabolism in the ICU: interrogating the underlying pathophysiology".
journals.lww.com/co-criticalc...
journals.lww.com/co-criticalc...
Reposted by Centre for Muscle Research (CMR)
A place for physiologist of Australia to connect, share, and promote each other’s work in cutting-edge research and education. Follow us to stay updated on the latest in physiology, events, and opportunities!
🔗 Tag your colleagues, share your research, and let’s grow this community together!
🔗 Tag your colleagues, share your research, and let’s grow this community together!
March 25, 2025 at 5:10 AM
A place for physiologist of Australia to connect, share, and promote each other’s work in cutting-edge research and education. Follow us to stay updated on the latest in physiology, events, and opportunities!
🔗 Tag your colleagues, share your research, and let’s grow this community together!
🔗 Tag your colleagues, share your research, and let’s grow this community together!
Reposted by Centre for Muscle Research (CMR)
The Australian Physiological Society (AuPS) is now on BlueSky:
@aups-physiology.bsky.social
@aups-physiology.bsky.social
June 11, 2025 at 3:44 AM
The Australian Physiological Society (AuPS) is now on BlueSky:
@aups-physiology.bsky.social
@aups-physiology.bsky.social
Congrats to Dr Dean Campelj, Prof Emma Rybalka & Team for their new JCSM paper "Haptoglobin & Glutamine Synthetase May Biomark Cachexia Induced by Antiacute Myeloid Leukaemia Chemotherapy" that also involved the CMR's @craigagoodman1.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Haptoglobin and Glutamine Synthetase May Biomark Cachexia Induced by Antiacute Myeloid Leukaemia Chemotherapy
Background Anticancer chemotherapy is an underappreciated contributor to cancer cachexia, an often-irreversible body-wasting condition that causes 20%–30% of cancer-related deaths. An obstacle to pr...
onlinelibrary.wiley.com
June 10, 2025 at 9:27 PM
Congrats to Dr Dean Campelj, Prof Emma Rybalka & Team for their new JCSM paper "Haptoglobin & Glutamine Synthetase May Biomark Cachexia Induced by Antiacute Myeloid Leukaemia Chemotherapy" that also involved the CMR's @craigagoodman1.bsky.social
onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com/doi/10.1002/...
Victorian Muscle Network (VMN)
✨SAVE THE DATE!✨
Please join us for the 8th Victorian Muscle Network Symposium to be held on Friday the 14th of November at Monash Caulfield Campus.
Keep an eye out for updates on keynote speakers and registrations👀
Looking forward to seeing you all there in 2025 🥳
✨SAVE THE DATE!✨
Please join us for the 8th Victorian Muscle Network Symposium to be held on Friday the 14th of November at Monash Caulfield Campus.
Keep an eye out for updates on keynote speakers and registrations👀
Looking forward to seeing you all there in 2025 🥳
June 5, 2025 at 7:13 AM
Victorian Muscle Network (VMN)
✨SAVE THE DATE!✨
Please join us for the 8th Victorian Muscle Network Symposium to be held on Friday the 14th of November at Monash Caulfield Campus.
Keep an eye out for updates on keynote speakers and registrations👀
Looking forward to seeing you all there in 2025 🥳
✨SAVE THE DATE!✨
Please join us for the 8th Victorian Muscle Network Symposium to be held on Friday the 14th of November at Monash Caulfield Campus.
Keep an eye out for updates on keynote speakers and registrations👀
Looking forward to seeing you all there in 2025 🥳
Well done Chris Karagiannis for delivering an outstanding PhD oration! The CMR and his supervisors, Prof Paul Gregorevic, @craigagoodman1.bsky.social & Dr Rachel Thomson, are proud. Now for the thesis.
#cancer #cachexia #muscle
#cancer #cachexia #muscle
June 4, 2025 at 9:17 PM
Well done Chris Karagiannis for delivering an outstanding PhD oration! The CMR and his supervisors, Prof Paul Gregorevic, @craigagoodman1.bsky.social & Dr Rachel Thomson, are proud. Now for the thesis.
#cancer #cachexia #muscle
#cancer #cachexia #muscle
Congrats Amy Bongetti on your PhD thesis submission!
Flanked by proud supervisors, Dr Marissa Caldow, Dr Yasmine Ali Abdelhamid , Prof Gordon Lynch
#muscle #ICU #physiology
Flanked by proud supervisors, Dr Marissa Caldow, Dr Yasmine Ali Abdelhamid , Prof Gordon Lynch
#muscle #ICU #physiology
May 24, 2025 at 10:14 PM
Congrats Amy Bongetti on your PhD thesis submission!
Flanked by proud supervisors, Dr Marissa Caldow, Dr Yasmine Ali Abdelhamid , Prof Gordon Lynch
#muscle #ICU #physiology
Flanked by proud supervisors, Dr Marissa Caldow, Dr Yasmine Ali Abdelhamid , Prof Gordon Lynch
#muscle #ICU #physiology
Check out the News and Views in @natmetabolism.nature.com by Sue Bodine & the CMR's @craigagoodman1.bsky.social on a new study from Troy Hornberger's lab on mechanically-sensitive MKK3b/6, p38, MK2, mTORC1 signaling mediating resistance exercise-induced muscle growth www.nature.com/articles/s42...
Mechanically sensitive MAPK signalling mediates resistance exercise-induced muscle growth - Nature Metabolism
Understanding the molecular regulators of skeletal muscle mass is essential for the future development of therapies that promote muscle growth and/or inhibit muscle wasting. A new study shows that mus...
www.nature.com
May 15, 2025 at 7:57 PM
Check out the News and Views in @natmetabolism.nature.com by Sue Bodine & the CMR's @craigagoodman1.bsky.social on a new study from Troy Hornberger's lab on mechanically-sensitive MKK3b/6, p38, MK2, mTORC1 signaling mediating resistance exercise-induced muscle growth www.nature.com/articles/s42...