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The study “Leucine inhibits degradation of outer mitochondrial membrane proteins to adapt mitochondrial respiration” in Nature Cell Biology 👇
www.nature.com/articles/s41...
Leucine inhibits degradation of outer mitochondrial membrane proteins to adapt mitochondrial respiration - Nature Cell Biology
Li et al. uncover a connection between metabolic cues and mitochondrial protein degradation, showing that specifically leucine stabilizes outer mitochondrial membrane proteins by inhibiting ubiquityla...
www.nature.com
October 31, 2025 at 1:33 PM
💬“We were thrilled to discover that a cell’s nutrient status, especially its leucine levels, directly impacts energy production,” said Dr Qiaochu Li, first author of the study. “This mechanism enables cells to swiftly adapt to increased energy demands during periods of nutrient abundance.”
October 31, 2025 at 1:33 PM
„Wir waren begeistert, [...] dass der Nährstoffstatus einer Zelle – insbesondere der Leucinspiegel – die Energieproduktion direkt beeinflusst“, sagt Dr. Qiaochu Li. „Dieser Mechanismus ermöglicht es den Zellen, sich in Zeiten des Nährstoffüberflusses rasch an den erhöhten Energiebedarf anzupassen.“
October 31, 2025 at 1:30 PM