Yes, and a lot of it is mediated through the gut microbiome.

The problem is how difficult it is to avoid artificial light at night! I believe one way to reduce the impact is to get some exposure to the sun around sunset.

There are so many things you can do for blood pressure that get at the root of the problem. Stretching, isometric exercise, nitric oxide supplements.
All these are backed by decent research.

The lived effects of adversity are complex: sometimes virtue emerges, but not always, and for some, hardship brings harm rather than growth

The article multiplies the sense of awe and wonder. Thanks for posting.

What toxicologists (vs. dentists) think: open.substack.com/pub/blanphea...

Here, one of the leading third-party testers found 6/10 brands they tested did not contain any.

The ones that did were some of the more expensive ones costing $1.6-$10/day (similar to what you described since you need 1g/day).
TBF some contain a combination of mitochondrial nutrients.

It's exciting this worked, but this is an extremely expensive supplement, and I wonder what other practices might provide similar benefits.

Urolithin A is a gut bacteria derived metabolite, but you need both the right bacteria and the right food intake.

That's my business, though, and I can tell you there's no country that really does proactive healthcare.

Anyways, public policy, agricultural policy, and the like do more for people's health overall. But we still need medical care, of course.

Other fun fact, we already pay more through various ways for patchy healthcare than people in other countries pay for universal healthcare.

This arose in the context of LDL targets. People with higher LDL have a relative risk of all cause mortality that is lower than 1, but the 95% confidence interval crosses unity.

So, in practice, what should we tell people with higher LDL?

Interestingly, and this is not about your frustration, I was just reflecting on this statistical significance problem.

As a physician, if a treatment has a 75% chance of being helpful, I'm likely to recommend it. I don't need it to be 95% or 97% correct in order to recommend it.

It's always fascinating to me that some people think in ways that would never in 1 million years have occurred to me.

And they make it their *mission,* yes, it's self serving, but I think they deeply believe in it.

Well, they're surely the ones brilliant enough to see it.

This is a very serious philosophical argument and has serious pushback as well. Do you hold back society when you insist on justice, or lose the valuable contribution of all the people you oppress?

They believe that justice holds exceptional people back.

I've seen this discussed seriously on LinkedIn.