Uli Klümper
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ulikluemper.bsky.social
Uli Klümper
@ulikluemper.bsky.social
Microbial Ecologist @ TU Dresden
Focusing on Evolution, Ecology and Environmental dimensions of AMR & plasmids
Formerly @ DTU & UoExeter
He/him
Having a great time at the 6th Meeting of Bergey’s Society for Microbial Systematics #BISMiS in Qingdao, China.

Thanks to the organizers for inviting me to give a talk on how we can infer pathogenicity and #AMR in environmental microbial communities based on their taxonomic makeup.
October 19, 2025 at 2:47 AM
Our first manuscript from the TARGIM project led by Masoud Haghshenasfard:

CFD and OCT-Based Optimisation of Impeller-Induced Shear Stress on Membrane Surfaces in a Circular Test Cell

www.sciencedirect.com/science/arti...
CFD and OCT-Based Optimisation of Impeller-Induced Shear Stress on Membrane Surfaces in a Circular Test Cell
This study investigates the distribution of shear stress in a lab-scale membrane bioreactor consisting of a 56 mm-diameter cylindrical test cell, a 0.…
www.sciencedirect.com
September 29, 2025 at 12:49 PM
🚨WORKSHOP announcement 🚨

“Making environmental #AMR Surveillance Fit for Purpose: Data Integration and the Ecology of Resistance”

6th of October
Dresden, Germany
Free of charge

one-bridge.iwaterfood.gr/workshops/wo...

Register now!

Details below:

1/3
ONE-Bridge project | Conference | Workshops
Fostering collaboration and addressing the interconnected challenges at the interface of human, animal, and environmental health.
one-bridge.iwaterfood.gr
September 21, 2025 at 12:49 PM
🐟💊🦠Our new study in @natwater.nature.com 🐟💊🦠

"Microbial risks triggered by oral administration of antibiotics in fish aquaculture persist long after the legally mandated antibiotic withdrawal time"

www.nature.com/articles/s44...

#microsky #amr
1/8
Microbial risks triggered by oral administration of antibiotics in fish aquaculture persist long after the legally mandated antibiotic withdrawal time - Nature Water
Florfenicol treatment substantially increased the abundance and mobility of antibiotic resistance genes (ARGs) in the common carp gut microbiome. The resistome and mobilome profiles failed to return t...
www.nature.com
September 21, 2025 at 11:11 AM
Reposted by Uli Klümper
What was antibiotic resistance like before we ever used antibiotics? How did we change what antibiotic resistance genes looked like over 100 years?

Our paper looking at resistance genes from a century of NCTC historical isolates now out in mGen:
www.microbiologyresearch.org/content/jour...
Genomic resistance in historical clinical isolates increased in frequency and mobility after the age of antibiotics
Antibiotic resistance is frequently observed shortly after the clinical introduction of an antibiotic. Whether and how frequently that resistance occurred before the introduction is harder to determin...
www.microbiologyresearch.org
September 1, 2025 at 5:49 PM
Excited to share our new Perspective in npj Antimicrobials & Resistance:

"Towards the integration of antibiotic resistance gene mobility into environmental surveillance and risk assessment.”

www.nature.com/articles/s44...

1/3

#AMR #microsky
Towards the integration of antibiotic resistance gene mobility into environmental surveillance and risk assessment - npj Antimicrobials and Resistance
npj Antimicrobials and Resistance - Towards the integration of antibiotic resistance gene mobility into environmental surveillance and risk assessment
www.nature.com
September 16, 2025 at 12:26 PM
First @biorxivpreprint.bsky.social from Eda Deniz Erdem's PhD:

"Selective spread of mobile antibiotic resistance genes in wastewater microbiomes driven by the non-antibiotic pharmaceutical carbamazepine"

www.biorxiv.org/content/10.1...

#AMR #microsky
Selective spread of mobile antibiotic resistance genes in wastewater microbiomes driven by the non-antibiotic pharmaceutical carbamazepine
Carbamazepine (CBZ), a widely used anticonvulsant, is a persistent aquatic micropollutant that withstands biodegradation and accumulates in wastewater-impacted environments. While non-antibiotic pharm...
www.biorxiv.org
September 10, 2025 at 8:45 AM
🧬💊Our new paper in @ismepublications.bsky.social🧬💊

"Ecology-based approach to predict no-effect antibiotic concentrations for minimizing environmental selection of resistance"

In collaboration with @umweltbundesamt.bsky.social

Read the thread below:

academic.oup.com/ismej/advanc...

#AMR

1/9
Ecology-based approach to predict no-effect antibiotic concentrations for minimizing environmental selection of resistance
Abstract. Selection for antibiotic resistance has been demonstrated at low, environmentally relevant antibiotic concentrations. The concept of minimum sele
academic.oup.com
August 11, 2025 at 11:57 AM
🧬🦠💊
🚨NEW COLLECTION LAUNCH🚨

I'm editing a new collection in npj Antimicrobials & Resistance:

"Ecological and Evolutionary Drivers of Environmental AMR"

Calling for submissions on environmental HGT, selection, invasion, mutation & more

Open till Apr 26

www.nature.com/collections/...
August 4, 2025 at 2:33 PM
Engineering soil with phages to fight #AMR. Very cool.

"Harnessing phage consortia to mitigate the soil antibiotic resistome by targeting keystone taxa Streptomyces"

by Hanpeng Liao et al. in @microbiomej.bsky.social

microbiomejournal.biomedcentral.com/articles/10....
Harnessing phage consortia to mitigate the soil antibiotic resistome by targeting keystone taxa Streptomyces - Microbiome
Background Antimicrobial resistance poses a substantial and growing threat to global health. While antibiotic resistance genes (ARGs) are tracked most closely in clinical settings, their spread remain...
microbiomejournal.biomedcentral.com
June 2, 2025 at 7:05 AM
Our new paper is online in ES&T Engineering:

"Evaluation of a Low-Cost Active Air Sampler for the Surveillance of Airborne Transmission of Antibiotic Resistance Genes Using a Municipal Wastewater Treatment Plant as a Case Study"

led by Naixiang Zhai and Jake O’Brien

pubs.acs.org/doi/10.1021/...
Evaluation of a Low-Cost Active Air Sampler for the Surveillance of Airborne Transmission of Antibiotic Resistance Genes Using a Municipal Wastewater Treatment Plant as a Case Study
Assessing the risks associated with antibiotic resistance genes (ARGs) in the environment remains challenging due to limited understanding of their distribution and transmission across various media, ...
pubs.acs.org
June 1, 2025 at 8:26 AM
Our new preprint as part of the #JPIAMR #SEARCHER project led by @remigsc.bsky.social & @etienneruppe.bsky.social uses functional metagenomics to identify novel resistances

"Environmental reservoir of resistance genes for the last resort antibiotic Cefiderocol"

www.biorxiv.org/content/10.1...
May 29, 2025 at 11:42 AM
Always love a good bacterial warfare study:

"Horizontal gene transfer of molecular weapons can reshape bacterial competition"

by @prokaryota.bsky.social, @jdpal.bsky.social, et al. in @plosbiology.org

journals.plos.org/plosbiology/...
Horizontal gene transfer of molecular weapons can reshape bacterial competition
Bacteria use molecular weapons such as toxins to outcompete rivals, but their horizontal gene transfer can undermine this advantage. This study shows that horizontal gene transfer of toxin plasmids is...
journals.plos.org
May 25, 2025 at 10:07 AM
The link between antibiotic resistance level and soil physico-chemical properties

by M. Szadziul, A. Goryluk-Salmonowicz & M. Popowska from our @biodiversa.eu #ANTIVERSA project

doi.org/10.1101/2025...

#AMR
The link between antibiotic resistance level and soil physico-chemical properties
Antimicrobial resistance (AMR) is a critical global health concern. While AMR research has primarily focused on medical and veterinary settings, the spread of antibiotic-resistant bacteria (ARB) and a...
doi.org
May 7, 2025 at 7:31 AM
Our new paper is online:

"Novel multi-drug-resistant yeast efficiently removes ammonia nitrogen from antibiotic-contaminated aquaculture water"

led by Jie Hu & Ling Luo in International Biodeterioration & Biodegradation

www.sciencedirect.com/science/arti...
Novel multi-drug-resistant yeast efficiently removed ammonia nitrogen from antibiotic-contaminated aquaculture water
Aquaculture waters often contain antibiotics, which inhibit the removal of ammonia nitrogen (NH4+-N) by traditional microbial technologies. Thus, it i…
www.sciencedirect.com
May 6, 2025 at 12:57 PM
Reposted by Uli Klümper
🧬💧 Wastewater & resistance: a global warning

A new study analysed 226 sludge samples from wastewater treatment plants across 6 continents. It found diverse, abundant antibiotic resistance genes in all plants.

🔗 doi.org/10.1038/s414...

#SciComm #Microbiology 🧪 #AMR
Global diversity and distribution of antibiotic resistance genes in human wastewater treatment systems - Nature Communications
Wastewater treatment plants are important reservoirs of antibiotic resistance genes (ARGs). Here, the authors analyze ARGs in a global collection of samples from wastewater treatment plants across six...
doi.org
May 1, 2025 at 4:19 AM
A framework to assess pharmaceutical accumulation in crops: from wastewater irrigation to consumption

by J. Nightingale, @carterlj.bsky.social et al.

doi.org/10.1016/j.jh...
Redirecting
doi.org
April 29, 2025 at 11:39 AM
Antimicrobial effects, and selection for AMR by non-antibiotic drugs in a wastewater bacterial community

by @aprilhayes.bsky.social, @edfeil.bsky.social, @willhgaze.bsky.social, @profjrsnape.bsky.social, @ecehh.org et al.

www.sciencedirect.com/science/arti...
www.sciencedirect.com
April 29, 2025 at 11:36 AM
Come to our conference:

International One Health Symposium 2025

Date: October 13th - 15th, 2025 in Berlin Germany.

Organized by the German @onehealthplatform.bsky.social

Registration and Abstract submission are open.
evis.events/event/571/
April 29, 2025 at 9:42 AM
Higher degree of metagenomic quantitativity urgently needed!

Microbial risk assessment across multiple environments based on metagenomic absolute quantification with cellular internal standards

in @naturewaterjnl.bsky.social by X. Shi, @zhangt1968.bsky.social et al.

www.nature.com/articles/s44...
Microbial risk assessment across multiple environments based on metagenomic absolute quantification with cellular internal standards - Nature Water
A cellular spike-in metagenomic method for absolute quantification of microorganisms in the aquatic environment is used to develop a risk assessment framework to support informed water quality managem...
www.nature.com
April 27, 2025 at 10:57 AM
New tool for AMR research:

argNorm allows normalising outputs from metagenomic #AMR analysis from different tools and databases to one common ontology

by @svetlanaup.bsky.social, @luispedrocoelho.bsky.social et al. as part of #JPIAMR projects #EMBARK & #SEARCHER

academic.oup.com/bioinformati...
argNorm: normalization of antibiotic resistance gene annotations to the Antibiotic Resistance Ontology (ARO)
AbstractSummary. Currently available and frequently used tools for annotating antimicrobial resistance genes (ARGs) in genomes and metagenomes provide resu
academic.oup.com
April 17, 2025 at 6:21 AM
Our new paper out in STOTEN:

Plastic-mediated transformation: A new route to navigate plasmid-borne antibiotic resistance genes

led by Ifra Ferheen & Roberto Spurio

doi.org/10.1016/j.sc...
#amr
Redirecting
doi.org
April 9, 2025 at 6:57 PM
Our new @biorxivpreprint.bsky.social together with the German Environmental Agency (@umweltbundesamt.bsky.social):

Suppressing selection for antibiotic resistance in the environment: A transparent, ecology-based approach to predicted no-effect concentrations

doi.org/10.1101/2025...
Suppressing selection for antibiotic resistance in the environment: A transparent, ecology-based approach to predicted no-effect concentrations
Selection for antibiotic resistance has been demonstrated at low, environmentally relevant antibiotic concentrations. Over the past decade, the concept of minimum selective concentrations (MSC) has be...
doi.org
April 5, 2025 at 9:08 AM
Reposted by Uli Klümper
Heute in der Sächsischen Zeitung:
Studie der @tudresden.bsky.social zeigt Zusammenhänge vom #Rauchen und #Antibiotikaresistenzen.
Das achtlose Wegwerfen der Kippen ist so gefährlich! 🤬
Beitrag der TU:
tu-dresden.de/tu-dresden/n....
April 1, 2025 at 1:08 PM
Thanks to #MDR for having my PhD student Diala Konyali and me (@tudresden.bsky.social) in a nice feature on the #Sachsenspiegel about our research on the spread of antibiotic resistance through cigarette butts

www.mdr.de/video/mdr-vi...

Read the paper in
ehp.niehs.nih.gov/doi/10.1289/...

#AMR
TU Dresden veröffentlicht Studie über Zigarettenstummel | MDR.DE
Pro Tag werden in Deutschland über 180 Millionen Zigaretten konsumiert. Die TU Dresden hat eine Studie zur Ausbreitung von Keimen aufgrund von Zigarettenstummeln veröffentlicht – mit überraschenden Er...
www.mdr.de
April 4, 2025 at 7:32 AM