T.T. Cooper
@ttcooper.bsky.social
Assistant Professor @ UdeM/CR-CHUM
Dad-of-4 Humans| Big Dogs 🐺
Coffee Addict☕
🇨🇦&🇺🇸
#SteelersNation
Scientist for Humanity👨🔬
Proteomics , EVs, and Machine Learning 🔬
#LetsGoPens
Dad-of-4 Humans| Big Dogs 🐺
Coffee Addict☕
🇨🇦&🇺🇸
#SteelersNation
Scientist for Humanity👨🔬
Proteomics , EVs, and Machine Learning 🔬
#LetsGoPens
I am interviewing a research associate tomorrow and also teach a class. Is wearing a Halloween costume a no-no?
October 30, 2025 at 11:59 PM
I am interviewing a research associate tomorrow and also teach a class. Is wearing a Halloween costume a no-no?
Not sure if I get more email from predatory journals or my kids school. I almost need a seperate email just to keep up with the events and pizza days.
October 30, 2025 at 6:51 PM
Not sure if I get more email from predatory journals or my kids school. I almost need a seperate email just to keep up with the events and pizza days.
Right now, I have the issue of too many good candidates for one position. I wish I could hire them all. Any advice how to narrow it down at this point? Cost of salary vs time to train is what stands out.
October 29, 2025 at 3:33 PM
Right now, I have the issue of too many good candidates for one position. I wish I could hire them all. Any advice how to narrow it down at this point? Cost of salary vs time to train is what stands out.
I am still looking for a research coordinator or associate. Please contact me if interested.
October 21, 2025 at 10:03 AM
I am still looking for a research coordinator or associate. Please contact me if interested.
Hosting 12 interviews for the lab manager position in my laboratory. Does anyone have advice on what makes a great candidate? I am a new PI so the majority of applications are fresh out of school. I want to give some the benefit of the doubt without it becoming the "blind leading the blind" 😅
September 5, 2025 at 4:14 PM
Hosting 12 interviews for the lab manager position in my laboratory. Does anyone have advice on what makes a great candidate? I am a new PI so the majority of applications are fresh out of school. I want to give some the benefit of the doubt without it becoming the "blind leading the blind" 😅
#TeamMassSpec Does anyone have advice on manual pipette companies?
August 28, 2025 at 7:03 PM
#TeamMassSpec Does anyone have advice on manual pipette companies?
Proteomic review has been submitted. I won't tell you the topic yet 🙃
August 5, 2025 at 6:46 PM
Proteomic review has been submitted. I won't tell you the topic yet 🙃
First task as a new PI. Submitted my LOI for NSERC - Discovery Grant. 🥳
August 1, 2025 at 10:12 PM
First task as a new PI. Submitted my LOI for NSERC - Discovery Grant. 🥳
Job Posting – Research Assistant
Location: CR-CHUM
Supervisor: Dr. Tyler Cooper
Dr. Cooper’s lab at the CR-CHUM is recruiting a research technician or assistant to our team focusing on proteomics and cancer EVs.
If interested, please send your CV and cover letter to tyler.cooper@umontreal.ca.
Location: CR-CHUM
Supervisor: Dr. Tyler Cooper
Dr. Cooper’s lab at the CR-CHUM is recruiting a research technician or assistant to our team focusing on proteomics and cancer EVs.
If interested, please send your CV and cover letter to tyler.cooper@umontreal.ca.
August 1, 2025 at 2:28 PM
Job Posting – Research Assistant
Location: CR-CHUM
Supervisor: Dr. Tyler Cooper
Dr. Cooper’s lab at the CR-CHUM is recruiting a research technician or assistant to our team focusing on proteomics and cancer EVs.
If interested, please send your CV and cover letter to tyler.cooper@umontreal.ca.
Location: CR-CHUM
Supervisor: Dr. Tyler Cooper
Dr. Cooper’s lab at the CR-CHUM is recruiting a research technician or assistant to our team focusing on proteomics and cancer EVs.
If interested, please send your CV and cover letter to tyler.cooper@umontreal.ca.
Le laboratoire du Dr Tyler Cooper au CR-CHUM recrute un·e technicien·ne ou assistant·e de laboratoire motivé·e pour se joindre à une équipe dynamique spécialisée en protéomique et EVs.
Si ce poste vous intéresse, veuillez envoyer votre CV et lettre de motivation à tyler.cooper@umontreal.ca.
Si ce poste vous intéresse, veuillez envoyer votre CV et lettre de motivation à tyler.cooper@umontreal.ca.
August 1, 2025 at 2:22 PM
Le laboratoire du Dr Tyler Cooper au CR-CHUM recrute un·e technicien·ne ou assistant·e de laboratoire motivé·e pour se joindre à une équipe dynamique spécialisée en protéomique et EVs.
Si ce poste vous intéresse, veuillez envoyer votre CV et lettre de motivation à tyler.cooper@umontreal.ca.
Si ce poste vous intéresse, veuillez envoyer votre CV et lettre de motivation à tyler.cooper@umontreal.ca.
Off to the next chapter. It's been unreal.
July 31, 2025 at 2:55 PM
Off to the next chapter. It's been unreal.
This is me at 11pm, after kids in bed, 2 days from becoming an assistant professor. Last experiment of my postdoc. Working on last fist author during centrifuge steps. Publish or perish. It's been a ride.
July 30, 2025 at 2:58 AM
This is me at 11pm, after kids in bed, 2 days from becoming an assistant professor. Last experiment of my postdoc. Working on last fist author during centrifuge steps. Publish or perish. It's been a ride.
If you have been trying to reach me by my Queen's email, and I have not responded yet. Please DM me here.
July 24, 2025 at 10:32 AM
If you have been trying to reach me by my Queen's email, and I have not responded yet. Please DM me here.
Reposted by T.T. Cooper
🚀 Check out our preprint on the new Thermo Scientific Orbitrap Astral Zoom MS 💫👇🏼
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Higher-Throughput Proteome Profiling Enabled by Parallelized Pre-Accumulation and Optimized Ion Processing in the Orbitrap Astral Zoom Mass Spectrometer
High-throughput proteomics is critical for understanding biological processes, enabling large-scale studies such as biomarker discovery and systems biology. However, current mass spectrometry technolo...
www.biorxiv.org
July 19, 2025 at 9:22 AM
🚀 Check out our preprint on the new Thermo Scientific Orbitrap Astral Zoom MS 💫👇🏼
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Yay! Congrats to the authors.
The Mag-Net paper is out! We've now put 1000s of plasma samples through this protocol and we know others have too. We've used it to study dozens of diseases. Looking forward to seeing what others apply this towards. The preprint already has >39 citations. www.nature.com/articles/s41...
Enrichment of extracellular vesicles using Mag-Net for the analysis of the plasma proteome - Nature Communications
Authors report MagNet, a plasma extracellular vesicle (EV) enrichment strategy using magnetic beads. Proteomic interrogation of this plasma EV fraction enables the detection of proteins that are beyon...
www.nature.com
July 1, 2025 at 9:11 PM
Yay! Congrats to the authors.
Reposted by T.T. Cooper
Boosting Orbitrap MS/MS speed to ∼70 Hz? 🚀
Read how we did it in our latest paper 👇
pubs.acs.org/doi/10.1021/...
Read how we did it in our latest paper 👇
pubs.acs.org/doi/10.1021/...
Enhancing Tandem MS Sensitivity and Peptide Identification via Ion Preaccumulation in an Orbitrap Mass Spectrometer
High-throughput mass spectrometry-based proteomics has gained increasing interest for both academic and industrial applications. As implementation of faster gradients has facilitated higher sample thr...
pubs.acs.org
July 1, 2025 at 12:29 PM
Boosting Orbitrap MS/MS speed to ∼70 Hz? 🚀
Read how we did it in our latest paper 👇
pubs.acs.org/doi/10.1021/...
Read how we did it in our latest paper 👇
pubs.acs.org/doi/10.1021/...
Reposted by T.T. Cooper
Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination.
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression
Schweizer et al. profile the tumor progression from non-invasive serous borderline
tumors of the ovary to metastatic low-grade serous ovarian cancer. By integrating
cell-type resolved Deep Visual Prot...
www.cell.com
June 26, 2025 at 3:20 PM
Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination.
www.cell.com/cancer-cell/...
www.cell.com/cancer-cell/...
If appropriate, where should I highlight in the manuscript that all the EV isolations and proteomics were done by hand and not robotics? In this day and age, it is almost a flex with how good my CVs are. 😂😂
a cartoon of a man holding a pair of gloves with the caption jazz hands
ALT: a cartoon of a man holding a pair of gloves with the caption jazz hands
media.tenor.com
June 26, 2025 at 5:33 PM
If appropriate, where should I highlight in the manuscript that all the EV isolations and proteomics were done by hand and not robotics? In this day and age, it is almost a flex with how good my CVs are. 😂😂
#TeamMassSpec Can anyone provide recommendations on building a custom computer for proteomic analysis?
June 25, 2025 at 10:48 AM
#TeamMassSpec Can anyone provide recommendations on building a custom computer for proteomic analysis?
Reposted by T.T. Cooper
How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by @ewholling.bsky.social, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. www.biorxiv.org/content/10.1... 1/
June 23, 2025 at 12:57 PM
How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by @ewholling.bsky.social, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. www.biorxiv.org/content/10.1... 1/
Edits for 1st review (non-invited) are done and off to co-authors before submission. The 2nd review (invited) is now back on my plate for edits, with a submission target of September 1st. Also need to review doctoral scholarships and write a few grants/papers before then.....😅
June 23, 2025 at 3:35 PM
Edits for 1st review (non-invited) are done and off to co-authors before submission. The 2nd review (invited) is now back on my plate for edits, with a submission target of September 1st. Also need to review doctoral scholarships and write a few grants/papers before then.....😅
OMG! OFFER WAS ACCEPTED! I have officially bought a house in Montreal! Lab opens August 1st!
May 28, 2025 at 5:50 PM
OMG! OFFER WAS ACCEPTED! I have officially bought a house in Montreal! Lab opens August 1st!
Put an offer on a house in Montreal. For sale sign just went up in my yard. S#!^ just got real. 😱
May 28, 2025 at 1:13 AM
Put an offer on a house in Montreal. For sale sign just went up in my yard. S#!^ just got real. 😱
Kicking off The inaugural #CanSEV2025
May 20, 2025 at 12:53 PM
Kicking off The inaugural #CanSEV2025