Tom Hindmarsh Sten
@tshindmarsh.bsky.social
Circuit architectures, dynamics, and the evolution of behavior. Jane Coffin Childs-HHMI Fellow in the Luo lab at Stanford University | Previously Ruta lab at Rockefeller
Pinned
Male-male interactions shape mate selection in Drosophila
Male-male competition strongly influences mate selection in Drosophila, with males
performing wing flicks to repel their rivals and jam a female’s perception of other
potential mates. Recruitment of p...
www.cell.com
Excited see the final portion of my PhD work with Vanessa Ruta out today in @cellpress.bsky.social, in the midst of everything.
In time for valentines day, @rufeili.bsky.social and I describe how competition between males sculpt mating decisions in 🪰🫶.
www.cell.com/cell/fulltex...
In time for valentines day, @rufeili.bsky.social and I describe how competition between males sculpt mating decisions in 🪰🫶.
www.cell.com/cell/fulltex...
Reposted by Tom Hindmarsh Sten
🎉 Cheng Lyu is the winner of the 2025 Eppendorf & Science Prize for Neurobiology for his work in understanding how neural circuits assemble with such remarkable precision during development.
Learn more: https://scim.ag/4onaxEE
Learn more: https://scim.ag/4onaxEE
October 30, 2025 at 7:31 PM
🎉 Cheng Lyu is the winner of the 2025 Eppendorf & Science Prize for Neurobiology for his work in understanding how neural circuits assemble with such remarkable precision during development.
Learn more: https://scim.ag/4onaxEE
Learn more: https://scim.ag/4onaxEE
Reposted by Tom Hindmarsh Sten
Excited to share our new #biorxivpreprint
We discovered that the fruit fly #drosophila erecta requires food odor to mate and arousal is further enhanced by social group motion.
Cross-species analysis of brain activity reveals a novel gate evolved from within a conserved circuit
shorturl.at/gGYm7
We discovered that the fruit fly #drosophila erecta requires food odor to mate and arousal is further enhanced by social group motion.
Cross-species analysis of brain activity reveals a novel gate evolved from within a conserved circuit
shorturl.at/gGYm7
October 16, 2025 at 6:34 AM
Excited to share our new #biorxivpreprint
We discovered that the fruit fly #drosophila erecta requires food odor to mate and arousal is further enhanced by social group motion.
Cross-species analysis of brain activity reveals a novel gate evolved from within a conserved circuit
shorturl.at/gGYm7
We discovered that the fruit fly #drosophila erecta requires food odor to mate and arousal is further enhanced by social group motion.
Cross-species analysis of brain activity reveals a novel gate evolved from within a conserved circuit
shorturl.at/gGYm7
Reposted by Tom Hindmarsh Sten
Exciting new Ruta lab preprint by @annaryba.bsky.social et al. on the neural underpinnings of intraspecific behavioral variation: Strain variation identifies a neural substrate for behavioral evolution Drosophila
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Strain variation identifies a neural substrate for behavioral evolution in Drosophila
Sexual selection acts on heritable differences within species, driving the parallel diversification of signal production in one sex and behavioral responses in the other. This coevolution implies that...
www.biorxiv.org
August 21, 2025 at 9:43 AM
Exciting new Ruta lab preprint by @annaryba.bsky.social et al. on the neural underpinnings of intraspecific behavioral variation: Strain variation identifies a neural substrate for behavioral evolution Drosophila
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Tom Hindmarsh Sten
My latest Aronov lab paper is now published @Nature!
When a chickadee looks at a distant location, the same place cells activate as if it were actually there 👁️
The hippocampus encodes where the bird is looking, AND what it expects to see next -- enabling spatial reasoning from afar
bit.ly/3HvWSum
When a chickadee looks at a distant location, the same place cells activate as if it were actually there 👁️
The hippocampus encodes where the bird is looking, AND what it expects to see next -- enabling spatial reasoning from afar
bit.ly/3HvWSum
June 11, 2025 at 10:24 PM
My latest Aronov lab paper is now published @Nature!
When a chickadee looks at a distant location, the same place cells activate as if it were actually there 👁️
The hippocampus encodes where the bird is looking, AND what it expects to see next -- enabling spatial reasoning from afar
bit.ly/3HvWSum
When a chickadee looks at a distant location, the same place cells activate as if it were actually there 👁️
The hippocampus encodes where the bird is looking, AND what it expects to see next -- enabling spatial reasoning from afar
bit.ly/3HvWSum
Reposted by Tom Hindmarsh Sten
Maps are everywhere in the brain...and finally we've discovered one in the nose! Led by @davidhbrann.bsky.social, we uncovered the logic that specifies the positions of each of the 1,000 sensory neuron subtypes in the nose and aligns their projections to the brain.👇👃see more details below👃👇
A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain
Although topographical maps organize many peripheral sensory systems, it remains unclear whether olfactory sensory neurons (OSNs) choose which of the ~1100 odor receptors (ORs) to express based upon t...
www.biorxiv.org
May 9, 2025 at 8:44 PM
Maps are everywhere in the brain...and finally we've discovered one in the nose! Led by @davidhbrann.bsky.social, we uncovered the logic that specifies the positions of each of the 1,000 sensory neuron subtypes in the nose and aligns their projections to the brain.👇👃see more details below👃👇
Reposted by Tom Hindmarsh Sten
Many animals use "adaptive control" to pursue moving objects, relying on flexible feedback loops to adjust their movement gain over time. But how do neural circuits actually implement this?
Here, we show how adaptive control in Drosophila pursuit involves two specialized parallel feedback loops.
Here, we show how adaptive control in Drosophila pursuit involves two specialized parallel feedback loops.
Specialized parallel pathways for adaptive control of visual object pursuit
To pursue an unpredictably moving visual object, the brain must generate motor commands that continuously steer the object to the midline of the visual field via feedback. Behavior implies that visual...
doi.org
April 28, 2025 at 3:19 PM
Many animals use "adaptive control" to pursue moving objects, relying on flexible feedback loops to adjust their movement gain over time. But how do neural circuits actually implement this?
Here, we show how adaptive control in Drosophila pursuit involves two specialized parallel feedback loops.
Here, we show how adaptive control in Drosophila pursuit involves two specialized parallel feedback loops.
Excited see the final portion of my PhD work with Vanessa Ruta out today in @cellpress.bsky.social, in the midst of everything.
In time for valentines day, @rufeili.bsky.social and I describe how competition between males sculpt mating decisions in 🪰🫶.
www.cell.com/cell/fulltex...
In time for valentines day, @rufeili.bsky.social and I describe how competition between males sculpt mating decisions in 🪰🫶.
www.cell.com/cell/fulltex...
Male-male interactions shape mate selection in Drosophila
Male-male competition strongly influences mate selection in Drosophila, with males
performing wing flicks to repel their rivals and jam a female’s perception of other
potential mates. Recruitment of p...
www.cell.com
February 14, 2025 at 2:02 AM
Excited see the final portion of my PhD work with Vanessa Ruta out today in @cellpress.bsky.social, in the midst of everything.
In time for valentines day, @rufeili.bsky.social and I describe how competition between males sculpt mating decisions in 🪰🫶.
www.cell.com/cell/fulltex...
In time for valentines day, @rufeili.bsky.social and I describe how competition between males sculpt mating decisions in 🪰🫶.
www.cell.com/cell/fulltex...
Reposted by Tom Hindmarsh Sten
Excited to have this paper out (rdcu.be/d0T3Y)! In it, we focused on how flies know what to attend to in a complex environment (like below)?
We uncovered neuronal pathways through which social states (like aggression 🥊) modulate visual processing in #Drosophila. #WomenInSTEM #neuroscience 🧪 1/
We uncovered neuronal pathways through which social states (like aggression 🥊) modulate visual processing in #Drosophila. #WomenInSTEM #neuroscience 🧪 1/
December 12, 2024 at 3:54 PM
Excited to have this paper out (rdcu.be/d0T3Y)! In it, we focused on how flies know what to attend to in a complex environment (like below)?
We uncovered neuronal pathways through which social states (like aggression 🥊) modulate visual processing in #Drosophila. #WomenInSTEM #neuroscience 🧪 1/
We uncovered neuronal pathways through which social states (like aggression 🥊) modulate visual processing in #Drosophila. #WomenInSTEM #neuroscience 🧪 1/
Reposted by Tom Hindmarsh Sten
In collaboration with Reuben Saunders, @jswlab.bsky.social, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue.
Check it out!
www.biorxiv.org/content/10.1...
Check it out!
www.biorxiv.org/content/10.1...
A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function
Organ function requires coordinated activities of thousands of genes in distinct, spatially organized cell types. Understanding the basis of emergent tissue function requires approaches to dissect the...
www.biorxiv.org
November 21, 2024 at 6:24 PM
In collaboration with Reuben Saunders, @jswlab.bsky.social, and Xiaowei Zhuang, we are very excited to release Perturb-Multi: a platform for pooled multimodal genetic screens in intact mammalian tissue.
Check it out!
www.biorxiv.org/content/10.1...
Check it out!
www.biorxiv.org/content/10.1...
Animals often congregate in large social groups to find mates. But how does an individual actually pick who to reproduce with? Incredibly excited to share the final piece of my graduate studies – a huge team effort to understand the logic of mate selection in Drosophila. bit.ly/flytriad
November 6, 2023 at 7:17 PM
Animals often congregate in large social groups to find mates. But how does an individual actually pick who to reproduce with? Incredibly excited to share the final piece of my graduate studies – a huge team effort to understand the logic of mate selection in Drosophila. bit.ly/flytriad