Tristan Rutland
@tristanrutland.bsky.social
Medical educator, medical doctor/anatomical pathologist at Liverpool hospital and lecturer at Western Sydney University.
🔬𝐓𝐫𝐢𝐩𝐥𝐞-𝐍𝐞𝐠𝐚𝐭𝐢𝐯𝐞 𝐁𝐫𝐞𝐚𝐬𝐭 𝐂𝐚𝐫𝐜𝐢𝐧𝐨𝐦𝐚 (𝐍𝐒𝐓) 🔬
⚠️ Pitfall alert
- TNBCs can have a range of morphologies
- DCIS is usually absent
- ❌ GATA3
- ✔️ SOX10 (mimic melanoma)
- Always do keratin + review patients history
#Breastpath #Dermpath #Pathtwitter #Pathresidents
⚠️ Pitfall alert
- TNBCs can have a range of morphologies
- DCIS is usually absent
- ❌ GATA3
- ✔️ SOX10 (mimic melanoma)
- Always do keratin + review patients history
#Breastpath #Dermpath #Pathtwitter #Pathresidents
January 2, 2025 at 11:58 PM
🔬𝐓𝐫𝐢𝐩𝐥𝐞-𝐍𝐞𝐠𝐚𝐭𝐢𝐯𝐞 𝐁𝐫𝐞𝐚𝐬𝐭 𝐂𝐚𝐫𝐜𝐢𝐧𝐨𝐦𝐚 (𝐍𝐒𝐓) 🔬
⚠️ Pitfall alert
- TNBCs can have a range of morphologies
- DCIS is usually absent
- ❌ GATA3
- ✔️ SOX10 (mimic melanoma)
- Always do keratin + review patients history
#Breastpath #Dermpath #Pathtwitter #Pathresidents
⚠️ Pitfall alert
- TNBCs can have a range of morphologies
- DCIS is usually absent
- ❌ GATA3
- ✔️ SOX10 (mimic melanoma)
- Always do keratin + review patients history
#Breastpath #Dermpath #Pathtwitter #Pathresidents
5/ Histological Features of FHD RCC:
🌴 Papillary, tubular, or solid patterns (occasionally nests).
🔴 Eosinophilic nucleoli resembling inclusions.
⭕ Perinuclear halos.
Image of primary renal tumour in case below
🌴 Papillary, tubular, or solid patterns (occasionally nests).
🔴 Eosinophilic nucleoli resembling inclusions.
⭕ Perinuclear halos.
Image of primary renal tumour in case below
December 17, 2024 at 11:27 PM
5/ Histological Features of FHD RCC:
🌴 Papillary, tubular, or solid patterns (occasionally nests).
🔴 Eosinophilic nucleoli resembling inclusions.
⭕ Perinuclear halos.
Image of primary renal tumour in case below
🌴 Papillary, tubular, or solid patterns (occasionally nests).
🔴 Eosinophilic nucleoli resembling inclusions.
⭕ Perinuclear halos.
Image of primary renal tumour in case below
4/ The Role of Fumarate Hydratase (FH):
FH is part of the The Citric Acid cycle (TCA), crucial for ATP production.
When mutated or lost (as seen on IHC), fumarate accumulates, creating a pseudo-hypoxic state.
This triggers transcription factors that suppress apoptosis and drive proliferation.
FH is part of the The Citric Acid cycle (TCA), crucial for ATP production.
When mutated or lost (as seen on IHC), fumarate accumulates, creating a pseudo-hypoxic state.
This triggers transcription factors that suppress apoptosis and drive proliferation.
December 17, 2024 at 11:27 PM
4/ The Role of Fumarate Hydratase (FH):
FH is part of the The Citric Acid cycle (TCA), crucial for ATP production.
When mutated or lost (as seen on IHC), fumarate accumulates, creating a pseudo-hypoxic state.
This triggers transcription factors that suppress apoptosis and drive proliferation.
FH is part of the The Citric Acid cycle (TCA), crucial for ATP production.
When mutated or lost (as seen on IHC), fumarate accumulates, creating a pseudo-hypoxic state.
This triggers transcription factors that suppress apoptosis and drive proliferation.
3b/
⚠️ NB: In patients with HLRCC, the uterine leiomyomas have a distinct appearance, cutaneous leiomyomas do not ⚠️ .
Sadly, 15-30% of patients with HLRCC will develop this aggressive RCC.
Cutaneous FHD leiomyoma below
⚠️ NB: In patients with HLRCC, the uterine leiomyomas have a distinct appearance, cutaneous leiomyomas do not ⚠️ .
Sadly, 15-30% of patients with HLRCC will develop this aggressive RCC.
Cutaneous FHD leiomyoma below
December 17, 2024 at 11:27 PM
3b/
⚠️ NB: In patients with HLRCC, the uterine leiomyomas have a distinct appearance, cutaneous leiomyomas do not ⚠️ .
Sadly, 15-30% of patients with HLRCC will develop this aggressive RCC.
Cutaneous FHD leiomyoma below
⚠️ NB: In patients with HLRCC, the uterine leiomyomas have a distinct appearance, cutaneous leiomyomas do not ⚠️ .
Sadly, 15-30% of patients with HLRCC will develop this aggressive RCC.
Cutaneous FHD leiomyoma below
𝐌𝐞𝐭𝐚𝐬𝐭𝐚𝐭𝐢𝐜 𝐅𝐮𝐦𝐚𝐫𝐚𝐭𝐞 𝐇𝐲𝐝𝐫𝐚𝐭𝐚𝐬𝐞 𝐃𝐞𝐟𝐢𝐜𝐢𝐞𝐧𝐭 𝐑𝐞𝐧𝐚𝐥 𝐂𝐞𝐥𝐥 𝐂𝐚𝐫𝐜𝐢𝐧𝐨𝐦𝐚 (𝐅𝐇𝐃 𝐑𝐂𝐂)
𝐅𝐇𝐃 𝐑𝐂𝐂 is a rare and highly aggressive tumour with a devastating prognosis—most cases present with metastases at diagnosis. Here’s what to know, a thread 🧵
#pathtwitter #GUpath #Medicine #Oncology #BSTpath
𝐅𝐇𝐃 𝐑𝐂𝐂 is a rare and highly aggressive tumour with a devastating prognosis—most cases present with metastases at diagnosis. Here’s what to know, a thread 🧵
#pathtwitter #GUpath #Medicine #Oncology #BSTpath
December 17, 2024 at 11:27 PM
𝐌𝐞𝐭𝐚𝐬𝐭𝐚𝐭𝐢𝐜 𝐅𝐮𝐦𝐚𝐫𝐚𝐭𝐞 𝐇𝐲𝐝𝐫𝐚𝐭𝐚𝐬𝐞 𝐃𝐞𝐟𝐢𝐜𝐢𝐞𝐧𝐭 𝐑𝐞𝐧𝐚𝐥 𝐂𝐞𝐥𝐥 𝐂𝐚𝐫𝐜𝐢𝐧𝐨𝐦𝐚 (𝐅𝐇𝐃 𝐑𝐂𝐂)
𝐅𝐇𝐃 𝐑𝐂𝐂 is a rare and highly aggressive tumour with a devastating prognosis—most cases present with metastases at diagnosis. Here’s what to know, a thread 🧵
#pathtwitter #GUpath #Medicine #Oncology #BSTpath
𝐅𝐇𝐃 𝐑𝐂𝐂 is a rare and highly aggressive tumour with a devastating prognosis—most cases present with metastases at diagnosis. Here’s what to know, a thread 🧵
#pathtwitter #GUpath #Medicine #Oncology #BSTpath