"an accurate pan-tissue, pan-histone-mark age predictor"😎

1814 ChIPseq samples
H3K4me3
H3K27ac
H3K9ac
H3K9me3
H3K27me3
H3K36me3
H3K4me1

82 tissues (incld large arteries)

"only a small fraction of the 62,241 features is sufficient to predict age"

#SciAdv 2024
www.science.org/doi/10.1126/...

🔬𝐓𝐫𝐢𝐩𝐥𝐞-𝐍𝐞𝐠𝐚𝐭𝐢𝐯𝐞 𝐁𝐫𝐞𝐚𝐬𝐭 𝐂𝐚𝐫𝐜𝐢𝐧𝐨𝐦𝐚 (𝐍𝐒𝐓) 🔬

⚠️ Pitfall alert

- TNBCs can have a range of morphologies

- DCIS is usually absent

- ❌ GATA3

- ✔️ SOX10 (mimic melanoma)

- Always do keratin + review patients history

#Breastpath #Dermpath #Pathtwitter #Pathresidents

⚕️ 𝗧𝗵𝗼𝗿𝗮𝗰𝗶𝗰 𝗦𝗠𝗔𝗥𝗖𝗔𝟰-𝗗𝗲𝗳𝗶𝗰𝗶𝗲𝗻𝘁 𝗨𝗻𝗱𝗶𝗳𝗳𝗲𝗿𝗲𝗻𝘁𝗶𝗮𝘁𝗲𝗱 𝗧𝘂𝗺𝗼𝘂𝗿 (𝗦𝗗𝗨𝗧)⚕️

As discussion below:

www.linkedin.com/posts/trista...

#Pathtwitter #Pulmpath #BSTpath

𝐌𝐞𝐭𝐚𝐬𝐭𝐚𝐭𝐢𝐜 𝐅𝐮𝐦𝐚𝐫𝐚𝐭𝐞 𝐇𝐲𝐝𝐫𝐚𝐭𝐚𝐬𝐞 𝐃𝐞𝐟𝐢𝐜𝐢𝐞𝐧𝐭 𝐑𝐞𝐧𝐚𝐥 𝐂𝐞𝐥𝐥 𝐂𝐚𝐫𝐜𝐢𝐧𝐨𝐦𝐚 (𝐅𝐇𝐃 𝐑𝐂𝐂)

𝐅𝐇𝐃 𝐑𝐂𝐂 is a rare and highly aggressive tumour with a devastating prognosis—most cases present with metastases at diagnosis. Here’s what to know, a thread 🧵
#pathtwitter #GUpath #Medicine #Oncology #BSTpath