(Tristan) Qingyun Li
@tristanli-lab.bsky.social
Assistant Professor at WashU Neuroscience and Genetics. Study microglial biology and neuroimmunology in brain development and disease.
Lab website: sites.wustl.edu/tristanlilab
Lab website: sites.wustl.edu/tristanlilab
Reposted by (Tristan) Qingyun Li
Thrilled to share our new paper @cp-cell.bsky.social:
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”
This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.
🔗 www.cell.com/cell/fulltex...
Faust et al., Cell 2025
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”
This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.
🔗 www.cell.com/cell/fulltex...
Faust et al., Cell 2025
September 12, 2025 at 1:21 PM
Thrilled to share our new paper @cp-cell.bsky.social:
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”
This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.
🔗 www.cell.com/cell/fulltex...
Faust et al., Cell 2025
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”
This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.
🔗 www.cell.com/cell/fulltex...
Faust et al., Cell 2025
It was a lot of fun co-writing this Spotlight with a talented graduate student @jingyiyang0321.bsky.social in my lab. Congrats to @fchrisbennett.bsky.social @nachoriko.bsky.social @waisenberg.bsky.social @Movahedi lab on these two important papers on microglia replacement! @cp-immunity.bsky.social
Hello world! My first post here, and it's a special one!
I'm excited to share that my first piece of work in grad school titled "Microglia Replacement: From Monocytic Origin to Therapy" is now online in Trends in Immunology!
Read it here: www.sciencedirect.com/science/arti...
I'm excited to share that my first piece of work in grad school titled "Microglia Replacement: From Monocytic Origin to Therapy" is now online in Trends in Immunology!
Read it here: www.sciencedirect.com/science/arti...
Microglia replacement: from monocytic origin to therapy
Microglia replacement is reshaping neurodegenerative disease therapy, yet its key prerequisites remain unclear. In the current issue of Immunity, Aise…
www.sciencedirect.com
May 26, 2025 at 4:41 PM
It was a lot of fun co-writing this Spotlight with a talented graduate student @jingyiyang0321.bsky.social in my lab. Congrats to @fchrisbennett.bsky.social @nachoriko.bsky.social @waisenberg.bsky.social @Movahedi lab on these two important papers on microglia replacement! @cp-immunity.bsky.social
Reposted by (Tristan) Qingyun Li
Thought this would be a nice way to enter the bsky community👇Delighted for Katie (now in Chris Dulla's lab at Tufts). Thank you to our collaborators, to the reviewers and to Cagla Eroglu for the highlight!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Norepinephrine signals through astrocytes to modulate synapses
Locus ceruleus (LC)–derived norepinephrine (NE) drives network and behavioral adaptations to environmental saliencies by reconfiguring circuit functional connectivity, but the underlying synapse-level...
www.science.org
May 16, 2025 at 4:34 AM
Thought this would be a nice way to enter the bsky community👇Delighted for Katie (now in Chris Dulla's lab at Tufts). Thank you to our collaborators, to the reviewers and to Cagla Eroglu for the highlight!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by (Tristan) Qingyun Li
Our lab's 1st paper, led by @fchrisbennett.bsky.social & @waisenberg.bsky.social. A decade thinking how to directly assess the impact of microglia replacement. Yrs of hard work. This kind of work is needed to expand brain disease care for kids & the vision for safer, more effective cell therapy.
Online now: Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease
Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease
Hematopoietic stem cell transplant is the gold standard for treatment of globoid cell leukodystrophy, also called Krabbe disease. Aisenberg et al. define the molecular signature of disease-associated macrophages (globoid cells) and demonstrate that brain-specific high-efficiency macrophage replacement in the twitcher model of Krabbe disease improves neuropathology, macrophage dysfunction, and survival.
dlvr.it
April 30, 2025 at 9:20 PM
Our lab's 1st paper, led by @fchrisbennett.bsky.social & @waisenberg.bsky.social. A decade thinking how to directly assess the impact of microglia replacement. Yrs of hard work. This kind of work is needed to expand brain disease care for kids & the vision for safer, more effective cell therapy.