Tyler Inskeep (they/them)
@trinskeep.bsky.social
PhD candidate in the Groen Lab @ UC Riverside. evolutionary systems biology, plant development, root-knot nematodes. they/them
this project began in the winter while plants and (root-knot) nematodes were bulking and experiments had to slow - thanks again to niels for supporting me in exploring new ideas and venturing out of my comfort zone!
www.biorxiv.org/content/10.1...
would love to hear your thoughts! ⬇️
www.biorxiv.org/content/10.1...
would love to hear your thoughts! ⬇️
Network properties constrain natural selection on gene expression in Caenorhabditis elegans
Gene regulatory networks (GRNs) integrate genetic and environmental signals to coordinate complex phenotypes and evolve through a balance of selection and drift. Using publicly available datasets from...
www.biorxiv.org
February 26, 2025 at 1:17 AM
this project began in the winter while plants and (root-knot) nematodes were bulking and experiments had to slow - thanks again to niels for supporting me in exploring new ideas and venturing out of my comfort zone!
www.biorxiv.org/content/10.1...
would love to hear your thoughts! ⬇️
www.biorxiv.org/content/10.1...
would love to hear your thoughts! ⬇️
we believe our findings are largely consistent with macroevolutionary theories of transcriptome evolution - this suggests that gene regulatory networks might evolve in similar ways across time scales
February 26, 2025 at 1:17 AM
we believe our findings are largely consistent with macroevolutionary theories of transcriptome evolution - this suggests that gene regulatory networks might evolve in similar ways across time scales
key takeaways
⚖️ selection is mostly weak - drift dominates!
🕸️ core genes face stronger stabilizing selection (but trans-regulatory variation can relax this)
🧠 tissue-specific genes are under stronger selection - with neuronal and reproductive tissues evolving the fastest
⚖️ selection is mostly weak - drift dominates!
🕸️ core genes face stronger stabilizing selection (but trans-regulatory variation can relax this)
🧠 tissue-specific genes are under stronger selection - with neuronal and reproductive tissues evolving the fastest
February 26, 2025 at 1:17 AM
key takeaways
⚖️ selection is mostly weak - drift dominates!
🕸️ core genes face stronger stabilizing selection (but trans-regulatory variation can relax this)
🧠 tissue-specific genes are under stronger selection - with neuronal and reproductive tissues evolving the fastest
⚖️ selection is mostly weak - drift dominates!
🕸️ core genes face stronger stabilizing selection (but trans-regulatory variation can relax this)
🧠 tissue-specific genes are under stronger selection - with neuronal and reproductive tissues evolving the fastest
what we did:
🧬 we used genotypic selection analyses to link variation in transcript levels to fecundity to test how natural selection shapes transcriptomes within a single generation
🕸️ we then integrated our models with network models to explore what constrains/drives transcriptome evolution
🧬 we used genotypic selection analyses to link variation in transcript levels to fecundity to test how natural selection shapes transcriptomes within a single generation
🕸️ we then integrated our models with network models to explore what constrains/drives transcriptome evolution
February 26, 2025 at 1:17 AM
what we did:
🧬 we used genotypic selection analyses to link variation in transcript levels to fecundity to test how natural selection shapes transcriptomes within a single generation
🕸️ we then integrated our models with network models to explore what constrains/drives transcriptome evolution
🧬 we used genotypic selection analyses to link variation in transcript levels to fecundity to test how natural selection shapes transcriptomes within a single generation
🕸️ we then integrated our models with network models to explore what constrains/drives transcriptome evolution