🙏 Huge thanks to our incredible lab and project team.
@kgoepfrich.bsky.social, Taniya Chakraborty,
@floppleton.bsky.social, Luca Monari, Maja Illig, and Franziska Giessler
This work couldn't be done without their support!
Looking forward to what’s next!

🌱 Furthermore, RNA origami structures can be genetically programmed to assemble inside cells and perform specific functions — opening new paths for synthetic cytoskeletons, scaffolding, or sensing.
Excited to explore new applications and collaborations! 🧬🤝
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💻 we built 1 micron RNA origami assemblies for coarse-grained simulation with oxRNA model
📊 the simulations manage to predict the persistence length almost correctly at 3.7 μm (experimental data: 3.4 μm)
📊 the phenotypic transition from nanotubes to nanorings is also elucidated by the simulations
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Our RNA nanotubes:
✔️ can be produced in situ and self-assemble inside liposomes
✔️ show tunable stiffness - flexible tubes can bundle at high Mg2+
✔️ subtle mutations lead to formation of nanorings instead of nanotubes (cover image)
✔️ form membrane cortex and deform membrane
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We engineered RNA tiles that fold co-transcriptionally and assemble in situ inside Giant Unilamellar Vesicles (GUVs)
No chemical synthesis needed — just a DNA template, rNTPs building blocks, and T7 polymerase.
A new route to building functional, evolvable synthetic cells.
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super nice pack! could I also be added? thank you ☺️