Mai Tran
@tranmai.bsky.social
RNA and DNA origamist
Currently searching for postdoc positions
PhD in @kgoepfrich.bsky.social working on building a syncell from RNA/DNA nanotech
Currently searching for postdoc positions
PhD in @kgoepfrich.bsky.social working on building a syncell from RNA/DNA nanotech
💻 we built 1 micron RNA origami assemblies for coarse-grained simulation with oxRNA model
📊 the simulations manage to predict the persistence length almost correctly at 3.7 μm (experimental data: 3.4 μm)
📊 the phenotypic transition from nanotubes to nanorings is also elucidated by the simulations
🧵👇
📊 the simulations manage to predict the persistence length almost correctly at 3.7 μm (experimental data: 3.4 μm)
📊 the phenotypic transition from nanotubes to nanorings is also elucidated by the simulations
🧵👇
May 26, 2025 at 11:26 AM
💻 we built 1 micron RNA origami assemblies for coarse-grained simulation with oxRNA model
📊 the simulations manage to predict the persistence length almost correctly at 3.7 μm (experimental data: 3.4 μm)
📊 the phenotypic transition from nanotubes to nanorings is also elucidated by the simulations
🧵👇
📊 the simulations manage to predict the persistence length almost correctly at 3.7 μm (experimental data: 3.4 μm)
📊 the phenotypic transition from nanotubes to nanorings is also elucidated by the simulations
🧵👇
Our RNA nanotubes:
✔️ can be produced in situ and self-assemble inside liposomes
✔️ show tunable stiffness - flexible tubes can bundle at high Mg2+
✔️ subtle mutations lead to formation of nanorings instead of nanotubes (cover image)
✔️ form membrane cortex and deform membrane
🧵👇
✔️ can be produced in situ and self-assemble inside liposomes
✔️ show tunable stiffness - flexible tubes can bundle at high Mg2+
✔️ subtle mutations lead to formation of nanorings instead of nanotubes (cover image)
✔️ form membrane cortex and deform membrane
🧵👇
May 26, 2025 at 11:26 AM
Our RNA nanotubes:
✔️ can be produced in situ and self-assemble inside liposomes
✔️ show tunable stiffness - flexible tubes can bundle at high Mg2+
✔️ subtle mutations lead to formation of nanorings instead of nanotubes (cover image)
✔️ form membrane cortex and deform membrane
🧵👇
✔️ can be produced in situ and self-assemble inside liposomes
✔️ show tunable stiffness - flexible tubes can bundle at high Mg2+
✔️ subtle mutations lead to formation of nanorings instead of nanotubes (cover image)
✔️ form membrane cortex and deform membrane
🧵👇
🧬 Thrilled to share that our work is featured on the cover of @natnano.nature.com (May issue)!
We genetically encoded RNA origami that self-assembles into cytoskeletal nanotubes inside synthetic cells.
📄 Paper: www.nature.com/articles/s41...
🧵👇
We genetically encoded RNA origami that self-assembles into cytoskeletal nanotubes inside synthetic cells.
📄 Paper: www.nature.com/articles/s41...
🧵👇
May 26, 2025 at 11:26 AM
🧬 Thrilled to share that our work is featured on the cover of @natnano.nature.com (May issue)!
We genetically encoded RNA origami that self-assembles into cytoskeletal nanotubes inside synthetic cells.
📄 Paper: www.nature.com/articles/s41...
🧵👇
We genetically encoded RNA origami that self-assembles into cytoskeletal nanotubes inside synthetic cells.
📄 Paper: www.nature.com/articles/s41...
🧵👇