Targeted protein degradation community
@tpd-community.bsky.social
Connecting the global TPD and ubiquitin biology community. Discover research labs, explore conferences, and stay in the loop on everything from E3 ligases to molecular glues.
TPD research map:
https://tpd-community.com/
TPD research map:
https://tpd-community.com/
Pinned
Welcome to the hub of Targeted Protein Degradation (TPD) and ubiquitin biology.
👋 Connecting the global TPD & ubiquitin biology community.
🔬 Find labs, discover events, and stay in the loop.
🌐 tpd-community.com
#TPD #Ubiquitin #ProteinDegradation
👋 Connecting the global TPD & ubiquitin biology community.
🔬 Find labs, discover events, and stay in the loop.
🌐 tpd-community.com
#TPD #Ubiquitin #ProteinDegradation
Reposted by Targeted protein degradation community
1 week to go! Würzburg's ready - are You? The GRK2243 Symposium 2025 is just around the corner. Pack your bags, prep your slides, and get hyped!
#wUeBI2025
#wUeBI2025
May 26, 2025 at 1:49 PM
1 week to go! Würzburg's ready - are You? The GRK2243 Symposium 2025 is just around the corner. Pack your bags, prep your slides, and get hyped!
#wUeBI2025
#wUeBI2025
Reposted by Targeted protein degradation community
Excited to share our latest study on how K29/K48-branched #ubiquitin chains are forged by the #E3 ligase TRIP12, and how this suggests a consensus mechanism for chain formation by HECT E3s!
@natsmb.nature.com
1/7
www.nature.com/articles/s41...
@natsmb.nature.com
1/7
www.nature.com/articles/s41...
TRIP12 structures reveal HECT E3 formation of K29 linkages and branched ubiquitin chains - Nature Structural & Molecular Biology
Using biochemistry, chemical biology, and cryo-EM, Maiwald et al. elucidate how TRIP12 forms K29 linkages and K29/K48-linked branched ubiquitin chains, revealing a mechanism for polyubiquitylation sha...
www.nature.com
May 26, 2025 at 9:37 AM
Excited to share our latest study on how K29/K48-branched #ubiquitin chains are forged by the #E3 ligase TRIP12, and how this suggests a consensus mechanism for chain formation by HECT E3s!
@natsmb.nature.com
1/7
www.nature.com/articles/s41...
@natsmb.nature.com
1/7
www.nature.com/articles/s41...
👏 Fantastic talk by Professor Craig Crews @craigmcrews.bsky.social at the Lund Spring Symposium on the past and future of PROTACs!
🎉 Congratulations on receiving The Special Achievement Award — well-deserved recognition for major contributions to TPD!
#TPD #PROTAC #LundSpringSymposium
🎉 Congratulations on receiving The Special Achievement Award — well-deserved recognition for major contributions to TPD!
#TPD #PROTAC #LundSpringSymposium
May 21, 2025 at 3:47 PM
👏 Fantastic talk by Professor Craig Crews @craigmcrews.bsky.social at the Lund Spring Symposium on the past and future of PROTACs!
🎉 Congratulations on receiving The Special Achievement Award — well-deserved recognition for major contributions to TPD!
#TPD #PROTAC #LundSpringSymposium
🎉 Congratulations on receiving The Special Achievement Award — well-deserved recognition for major contributions to TPD!
#TPD #PROTAC #LundSpringSymposium
🗺️ Interactive Map Update!
2 new UK-based labs have been added to the global TPD map:
🔹 Kessler Lab @kesslerbenedikt001.bsky.social
🔹 Fletcher Lab
Explore these and many other TPD and ubiquitin labs:
👉 tpd-community.com
#TPD #ProteinDegradation #Ubiquitin
2 new UK-based labs have been added to the global TPD map:
🔹 Kessler Lab @kesslerbenedikt001.bsky.social
🔹 Fletcher Lab
Explore these and many other TPD and ubiquitin labs:
👉 tpd-community.com
#TPD #ProteinDegradation #Ubiquitin
May 19, 2025 at 8:20 AM
🗺️ Interactive Map Update!
2 new UK-based labs have been added to the global TPD map:
🔹 Kessler Lab @kesslerbenedikt001.bsky.social
🔹 Fletcher Lab
Explore these and many other TPD and ubiquitin labs:
👉 tpd-community.com
#TPD #ProteinDegradation #Ubiquitin
2 new UK-based labs have been added to the global TPD map:
🔹 Kessler Lab @kesslerbenedikt001.bsky.social
🔹 Fletcher Lab
Explore these and many other TPD and ubiquitin labs:
👉 tpd-community.com
#TPD #ProteinDegradation #Ubiquitin
🗺️ Interactive Map Update!
The Münch Lab @cmunch.bsky.social has joined the global TPD map! 🎉
Explore their work and discover other labs studying #TPD and #ubiquitin biology.
👉 tpd-community.com
#ProteinDegradation
The Münch Lab @cmunch.bsky.social has joined the global TPD map! 🎉
Explore their work and discover other labs studying #TPD and #ubiquitin biology.
👉 tpd-community.com
#ProteinDegradation
May 17, 2025 at 1:42 PM
🗺️ Interactive Map Update!
The Münch Lab @cmunch.bsky.social has joined the global TPD map! 🎉
Explore their work and discover other labs studying #TPD and #ubiquitin biology.
👉 tpd-community.com
#ProteinDegradation
The Münch Lab @cmunch.bsky.social has joined the global TPD map! 🎉
Explore their work and discover other labs studying #TPD and #ubiquitin biology.
👉 tpd-community.com
#ProteinDegradation
🗺️ Interactive Map Update!
The map was just updated with 3 more labs from Germany working on TPD:
🔹 Hausch Lab
🔹 Knapp Lab
🔹 Gersch Lab @maltegersch.bsky.social
Explore these and other labs advancing TPD and ubiquitin biology:
👉 tpd-community.com
#TPD #ProteinDegradation #Ubiquitin
The map was just updated with 3 more labs from Germany working on TPD:
🔹 Hausch Lab
🔹 Knapp Lab
🔹 Gersch Lab @maltegersch.bsky.social
Explore these and other labs advancing TPD and ubiquitin biology:
👉 tpd-community.com
#TPD #ProteinDegradation #Ubiquitin
May 15, 2025 at 1:24 PM
🗺️ Interactive Map Update!
The map was just updated with 3 more labs from Germany working on TPD:
🔹 Hausch Lab
🔹 Knapp Lab
🔹 Gersch Lab @maltegersch.bsky.social
Explore these and other labs advancing TPD and ubiquitin biology:
👉 tpd-community.com
#TPD #ProteinDegradation #Ubiquitin
The map was just updated with 3 more labs from Germany working on TPD:
🔹 Hausch Lab
🔹 Knapp Lab
🔹 Gersch Lab @maltegersch.bsky.social
Explore these and other labs advancing TPD and ubiquitin biology:
👉 tpd-community.com
#TPD #ProteinDegradation #Ubiquitin
Reposted by Targeted protein degradation community
Great to see this out. A story that spanned continents, cities and budget codes…
www.nature.com/articles/s41...
Big thanks to all the teams involved!
@clausenlab.bsky.social @e3chembio.bsky.social
www.nature.com/articles/s41...
Big thanks to all the teams involved!
@clausenlab.bsky.social @e3chembio.bsky.social
ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213 - Nature Communications
RNF213 is an E3 ligase with ATPase activity. Here, the authors show that RNF213 is activated by ATP binding and senses cellular energy states, and reveal a transthiolation mechanism induced by immune ...
www.nature.com
May 13, 2025 at 9:51 AM
Great to see this out. A story that spanned continents, cities and budget codes…
www.nature.com/articles/s41...
Big thanks to all the teams involved!
@clausenlab.bsky.social @e3chembio.bsky.social
www.nature.com/articles/s41...
Big thanks to all the teams involved!
@clausenlab.bsky.social @e3chembio.bsky.social
🔬 Lab Spotlight: Malte Gersch Lab at Max Planck & TU Dortmund @maltegersch.bsky.social
Recent paper: New insights into DUB inhibition & crystallization! 👉 www.nature.com/articles/s41...
Recent paper: New insights into DUB inhibition & crystallization! 👉 www.nature.com/articles/s41...
Chimeric deubiquitinase engineering reveals structural basis for specific inhibition of the mitophagy regulator USP30 - Nature Structural & Molecular Biology
Kazi et al. report the crystal structure of the mitochondrial deubiquitinase USP30, a clinical stage Parkinson’s disease drug target, in complex with a specific inhibitor. The authors delineate a fram...
www.nature.com
May 13, 2025 at 7:04 AM
🔬 Lab Spotlight: Malte Gersch Lab at Max Planck & TU Dortmund @maltegersch.bsky.social
Recent paper: New insights into DUB inhibition & crystallization! 👉 www.nature.com/articles/s41...
Recent paper: New insights into DUB inhibition & crystallization! 👉 www.nature.com/articles/s41...
🧬 Exploring degraders? Check out PROTAC-DB — a free, searchable resource with data on 3,200+ PROTACs, warheads, linkers, E3 ligands, and more.
Includes binding data, degradation metrics, ternary structures, and WB images.
🔗 Dive in: cadd.zju.edu.cn/protacdb/
#PROTAC #TPD #DrugDiscovery
Includes binding data, degradation metrics, ternary structures, and WB images.
🔗 Dive in: cadd.zju.edu.cn/protacdb/
#PROTAC #TPD #DrugDiscovery
May 9, 2025 at 3:18 PM
🧬 Exploring degraders? Check out PROTAC-DB — a free, searchable resource with data on 3,200+ PROTACs, warheads, linkers, E3 ligands, and more.
Includes binding data, degradation metrics, ternary structures, and WB images.
🔗 Dive in: cadd.zju.edu.cn/protacdb/
#PROTAC #TPD #DrugDiscovery
Includes binding data, degradation metrics, ternary structures, and WB images.
🔗 Dive in: cadd.zju.edu.cn/protacdb/
#PROTAC #TPD #DrugDiscovery
Reposted by Targeted protein degradation community
Day 1 one #ubfriends2025 was full of great 🎤talks, creative elevator pitches, lively poster sessions and stimulating discussions...
May 9, 2025 at 11:15 AM
Day 1 one #ubfriends2025 was full of great 🎤talks, creative elevator pitches, lively poster sessions and stimulating discussions...
🗺️ TPD Research Map Update!
5 new labs just joined the global TPD map:
🔹 Slabicki Lab
🔹 Kaneko Lab
🔹 Wiener Lab
🔹 Korenblit Lab
🔹 Zhuang Lab
Explore these and many other labs working on targeted protein degradation and ubiquitin biology!
👉 tpd-community.com
#TPD #ProteinDegradation #Ubiquitin
5 new labs just joined the global TPD map:
🔹 Slabicki Lab
🔹 Kaneko Lab
🔹 Wiener Lab
🔹 Korenblit Lab
🔹 Zhuang Lab
Explore these and many other labs working on targeted protein degradation and ubiquitin biology!
👉 tpd-community.com
#TPD #ProteinDegradation #Ubiquitin
May 8, 2025 at 1:11 PM
🗺️ TPD Research Map Update!
5 new labs just joined the global TPD map:
🔹 Slabicki Lab
🔹 Kaneko Lab
🔹 Wiener Lab
🔹 Korenblit Lab
🔹 Zhuang Lab
Explore these and many other labs working on targeted protein degradation and ubiquitin biology!
👉 tpd-community.com
#TPD #ProteinDegradation #Ubiquitin
5 new labs just joined the global TPD map:
🔹 Slabicki Lab
🔹 Kaneko Lab
🔹 Wiener Lab
🔹 Korenblit Lab
🔹 Zhuang Lab
Explore these and many other labs working on targeted protein degradation and ubiquitin biology!
👉 tpd-community.com
#TPD #ProteinDegradation #Ubiquitin
📢 Next week at the DFCI TPD Seminar (May 15, 12PM EST):
🎙️ Talks by Rebecca Metivier and Martin Steger on using mass spec proteomics to uncover degrader targets.
Don’t miss it!
#TPD #Proteomics #Degraders
🎙️ Talks by Rebecca Metivier and Martin Steger on using mass spec proteomics to uncover degrader targets.
Don’t miss it!
#TPD #Proteomics #Degraders
Excited to be hosting next week’s DFCI TPD seminar! We’ll hear from two outstanding speakers, Rebecca Metivier and Martin Steger who will share their work on developing and applying mass spectrometry-based proteomics platforms to identify and catalog degrader targets.
See you on May 15th @ 12PM EST
See you on May 15th @ 12PM EST
May 7, 2025 at 7:51 AM
📢 Next week at the DFCI TPD Seminar (May 15, 12PM EST):
🎙️ Talks by Rebecca Metivier and Martin Steger on using mass spec proteomics to uncover degrader targets.
Don’t miss it!
#TPD #Proteomics #Degraders
🎙️ Talks by Rebecca Metivier and Martin Steger on using mass spec proteomics to uncover degrader targets.
Don’t miss it!
#TPD #Proteomics #Degraders
PVDF vs Nitrocellulose? How to Choose a Blot Membrane 🤔
If you're optimizing your blots, this guide from Fisher Scientific breaks down when and why membrane matters:
📌 Also includes practical tips for handling and troubleshooting.
#WesternBlot #LifeScienceTips
If you're optimizing your blots, this guide from Fisher Scientific breaks down when and why membrane matters:
📌 Also includes practical tips for handling and troubleshooting.
#WesternBlot #LifeScienceTips
www.thermofisher.com
May 6, 2025 at 6:42 PM
PVDF vs Nitrocellulose? How to Choose a Blot Membrane 🤔
If you're optimizing your blots, this guide from Fisher Scientific breaks down when and why membrane matters:
📌 Also includes practical tips for handling and troubleshooting.
#WesternBlot #LifeScienceTips
If you're optimizing your blots, this guide from Fisher Scientific breaks down when and why membrane matters:
📌 Also includes practical tips for handling and troubleshooting.
#WesternBlot #LifeScienceTips
🔬 New from the Itay Koren lab:
💥 TOM20 anchors an E3 ligase to drive UPS-dependent control of mitochondrial fusion/fission via PLD6 degradation.
doi.org/10.1038/s415...
👏 Congrats to all authors!
📍 Find the Koren lab + others on our map: tpd-community.com
#Ubiquitin #ProteinDegradation
💥 TOM20 anchors an E3 ligase to drive UPS-dependent control of mitochondrial fusion/fission via PLD6 degradation.
doi.org/10.1038/s415...
👏 Congrats to all authors!
📍 Find the Koren lab + others on our map: tpd-community.com
#Ubiquitin #ProteinDegradation
May 4, 2025 at 3:39 PM
🔬 New from the Itay Koren lab:
💥 TOM20 anchors an E3 ligase to drive UPS-dependent control of mitochondrial fusion/fission via PLD6 degradation.
doi.org/10.1038/s415...
👏 Congrats to all authors!
📍 Find the Koren lab + others on our map: tpd-community.com
#Ubiquitin #ProteinDegradation
💥 TOM20 anchors an E3 ligase to drive UPS-dependent control of mitochondrial fusion/fission via PLD6 degradation.
doi.org/10.1038/s415...
👏 Congrats to all authors!
📍 Find the Koren lab + others on our map: tpd-community.com
#Ubiquitin #ProteinDegradation
🚨 Next week!
The Ubiquitin & Friends Symposium 2025 in Vienna 🇦🇹, May 8–9!
Great science, great people, and great event for anyone into ubiquitin & TPD.
🔗 www.protein-degradation.org/symposium/
👥 Organizers: @sfb-tpd-vienna.bsky.social
#TPD #Ubiquitin #ProteinDegradation
The Ubiquitin & Friends Symposium 2025 in Vienna 🇦🇹, May 8–9!
Great science, great people, and great event for anyone into ubiquitin & TPD.
🔗 www.protein-degradation.org/symposium/
👥 Organizers: @sfb-tpd-vienna.bsky.social
#TPD #Ubiquitin #ProteinDegradation
Targeted Protein Degradation • From Small Molecules To Complex Organelles
Our Special Research Program is a collaborative research platform to unravel how proteins are targeted for degradation.
www.protein-degradation.org
May 2, 2025 at 2:14 PM
🚨 Next week!
The Ubiquitin & Friends Symposium 2025 in Vienna 🇦🇹, May 8–9!
Great science, great people, and great event for anyone into ubiquitin & TPD.
🔗 www.protein-degradation.org/symposium/
👥 Organizers: @sfb-tpd-vienna.bsky.social
#TPD #Ubiquitin #ProteinDegradation
The Ubiquitin & Friends Symposium 2025 in Vienna 🇦🇹, May 8–9!
Great science, great people, and great event for anyone into ubiquitin & TPD.
🔗 www.protein-degradation.org/symposium/
👥 Organizers: @sfb-tpd-vienna.bsky.social
#TPD #Ubiquitin #ProteinDegradation
🔬 GRK2243 Symposium – Understanding Ubiquitylation
📅 June 2–4, 2025
📍 Würzburg, Germany
A 3-day deep dive into ubiquitin biology—from molecular mechanisms to disease and therapeutic strategies.
👥 Hosted by @GRK2243
🔗 Full info: www.ubiquitin-wuerzburg-2025.de
#TPD #Ubiquitin #wUeBI2025
📅 June 2–4, 2025
📍 Würzburg, Germany
A 3-day deep dive into ubiquitin biology—from molecular mechanisms to disease and therapeutic strategies.
👥 Hosted by @GRK2243
🔗 Full info: www.ubiquitin-wuerzburg-2025.de
#TPD #Ubiquitin #wUeBI2025
May 2, 2025 at 9:40 AM
🔬 GRK2243 Symposium – Understanding Ubiquitylation
📅 June 2–4, 2025
📍 Würzburg, Germany
A 3-day deep dive into ubiquitin biology—from molecular mechanisms to disease and therapeutic strategies.
👥 Hosted by @GRK2243
🔗 Full info: www.ubiquitin-wuerzburg-2025.de
#TPD #Ubiquitin #wUeBI2025
📅 June 2–4, 2025
📍 Würzburg, Germany
A 3-day deep dive into ubiquitin biology—from molecular mechanisms to disease and therapeutic strategies.
👥 Hosted by @GRK2243
🔗 Full info: www.ubiquitin-wuerzburg-2025.de
#TPD #Ubiquitin #wUeBI2025
🧬 Want to see who’s working on Targeted Protein Degradation or ubiquitin biology?
🔍 Explore our interactive map of research labs worldwide:
🌐 tpd-community.com#the-map
Discover labs and find collaborators.
#TPD #Ubiquitin #ProteinDegradation #ResearchMap
🔍 Explore our interactive map of research labs worldwide:
🌐 tpd-community.com#the-map
Discover labs and find collaborators.
#TPD #Ubiquitin #ProteinDegradation #ResearchMap
May 1, 2025 at 4:59 PM
🧬 Want to see who’s working on Targeted Protein Degradation or ubiquitin biology?
🔍 Explore our interactive map of research labs worldwide:
🌐 tpd-community.com#the-map
Discover labs and find collaborators.
#TPD #Ubiquitin #ProteinDegradation #ResearchMap
🔍 Explore our interactive map of research labs worldwide:
🌐 tpd-community.com#the-map
Discover labs and find collaborators.
#TPD #Ubiquitin #ProteinDegradation #ResearchMap
Welcome to the hub of Targeted Protein Degradation (TPD) and ubiquitin biology.
👋 Connecting the global TPD & ubiquitin biology community.
🔬 Find labs, discover events, and stay in the loop.
🌐 tpd-community.com
#TPD #Ubiquitin #ProteinDegradation
👋 Connecting the global TPD & ubiquitin biology community.
🔬 Find labs, discover events, and stay in the loop.
🌐 tpd-community.com
#TPD #Ubiquitin #ProteinDegradation
May 1, 2025 at 1:43 PM
Welcome to the hub of Targeted Protein Degradation (TPD) and ubiquitin biology.
👋 Connecting the global TPD & ubiquitin biology community.
🔬 Find labs, discover events, and stay in the loop.
🌐 tpd-community.com
#TPD #Ubiquitin #ProteinDegradation
👋 Connecting the global TPD & ubiquitin biology community.
🔬 Find labs, discover events, and stay in the loop.
🌐 tpd-community.com
#TPD #Ubiquitin #ProteinDegradation