🦠Identifican un mecanismo que protege a las células de la mutación natural del ADN más frecuente

🔬El @cib-csic.bsky.social ‬desvela que una enzima detecta eficazmente dichas mutaciones

👨‍🔬Abre el camino a nuevas aplicaciones biomédicas

#CIBpapers

@tornerolab.bsky.social at @cib-csic.bsky.social has unveiled one of the mechanisms used by eukaryotic cells to detect the most frequent natural #mutation in #DNA.

🔗https://f.mtr.cool/dvxaprqbng

#CIBpapers
A team led by Nuria Campillo's group at @cib-csic.bsky.social has developed an innovative IA strategy to design therapeutic molecules from scratch, even with limited data.

🔗https://f.mtr.cool/ihgnvvcguy

Exciting news! Our latest article is out NOW at @natcomms.nature.com. We describe the pausing-stalling mechanism of detection of abasic lesions by RNA Pol I:
www.nature.com/articles/s41...

Congratulations, Álvaro! Much deserved :)

The group of Carlos Fdez Tornero's at @cib-csic.bsky.social will implement AI tools to identify new drugs against sleeping sickness, a neglected parasitic disease that mainly affects sub-Saharan Africa and has a high mortality rate if not treated in time.

The @csic.es has received 1 million dollars from Google.org to develop AI models to search for new drugs (@cib-csic.bsky.social)  and advanced robotic therapies (CAR-CSIC).

🔗https://f.mtr.cool/wroqocpefp

We are excited to share that we have started a new research line to develop AI tools for targeted drug design. We will start from whole pathogen genomes, predict potential targets and their structure, and finish by screening drug libraries. All this funded by google.org!
cib.csic.es/news/researc...

Mature #HIV-1 contains >2000 copies of “spacer peptide 2”, but we didn’t know why. We now see that SP2 binds the matrix protein and triggers the change into its mature arrangement. Summary video from @margotriggi.bsky.social

We are delighted to welcome our newest addition to the group, PhD candidate Clara Ducoli! Benvenuta 🇮🇹😀

We are excited to announce the first Salamanca Biophysics Summer Course organized by Carlos Bustamante and Eva Nogales. See the flyer below and consider applying!

We're excited to explore new communities here in Bluesky!
In the meantime, here is our latest preprint, in case you missed it - we share our #CryoEM study of Pol I stalling mechanism at abasic lesions, and the interesting configurations that we found on our way there:
www.biorxiv.org/content/10.1...