Tomás Quiroga
@tomyquiroga.bsky.social
PhD student at the Institute for Bioengineering of Catalonia (IBEC) | Deep mutational scanning
Reposted by Tomás Quiroga
New cocktail 🍹 in town - in collaboration with @benlehner.bsky.social : Massive combinatorial mutagenesis + amyloid kinetics selection + thermodynamic modelling showing us the portrait 🎨 of an amyloid transition state. Read about it in this great thread:
Alzheimer’s disease 🧠starts with a molecular domino effect - but what triggers the first piece to fall?
In our new study we cracked open the black box of early protein aggregation, and the findings could reshape how we fight neurodegeneration. 🧵👇
www.science.org/doi/10.1126/...
In our new study we cracked open the black box of early protein aggregation, and the findings could reshape how we fight neurodegeneration. 🧵👇
www.science.org/doi/10.1126/...
Massively parallel genetic perturbation suggests the energetic structure of an amyloid-β transition state
The aggregation rates of >140,000 mutants reveal the energetic structure of an amyloid-β nucleation reaction transition state.
www.science.org
June 12, 2025 at 1:30 PM
New cocktail 🍹 in town - in collaboration with @benlehner.bsky.social : Massive combinatorial mutagenesis + amyloid kinetics selection + thermodynamic modelling showing us the portrait 🎨 of an amyloid transition state. Read about it in this great thread:
Reposted by Tomás Quiroga
Good morning #VariantEffect25! Kicking things off we have Mafalda Dias, @bennibolo.bsky.social @muffley.bsky.social welcoming us to this 8th annual symposium. We have 250 in-person participants, 60 people online, from 20 countries!
May 21, 2025 at 7:45 AM
Good morning #VariantEffect25! Kicking things off we have Mafalda Dias, @bennibolo.bsky.social @muffley.bsky.social welcoming us to this 8th annual symposium. We have 250 in-person participants, 60 people online, from 20 countries!
Reposted by Tomás Quiroga
The Mutational Scanning Symposium just began! 💫🔬
Eperts in the fields of functional genomics, protein science, precision medicine, variant interpretation, and computational genetics provide insights on the future of this science.
#VariantEffect25
Eperts in the fields of functional genomics, protein science, precision medicine, variant interpretation, and computational genetics provide insights on the future of this science.
#VariantEffect25
May 21, 2025 at 10:37 AM
The Mutational Scanning Symposium just began! 💫🔬
Eperts in the fields of functional genomics, protein science, precision medicine, variant interpretation, and computational genetics provide insights on the future of this science.
#VariantEffect25
Eperts in the fields of functional genomics, protein science, precision medicine, variant interpretation, and computational genetics provide insights on the future of this science.
#VariantEffect25
Reposted by Tomás Quiroga
The first poster session just started! #VariantEffect25
May 21, 2025 at 11:39 AM
The first poster session just started! #VariantEffect25