Matt Johnson ❄️🔬🦠
@tiltedscientist.bsky.social
Researcher in situ structural biology using CryoET (Melb, Australia). Father, Greyhound companion, coffee enthusiast, and willing but not able golfer.
Reposted by Matt Johnson ❄️🔬🦠
Last week we had the CCeMMP Symposium 2025. Fantastic event with an outstanding line-up of speakers. There were 2 poster prizes and 1 oral presentation prize; thrilled that we did a clean sweep! Huge congratulations @tiltedscientist.bsky.social @somavallyd.bsky.social and @lucatroman.bsky.social
November 17, 2025 at 2:17 PM
Last week we had the CCeMMP Symposium 2025. Fantastic event with an outstanding line-up of speakers. There were 2 poster prizes and 1 oral presentation prize; thrilled that we did a clean sweep! Huge congratulations @tiltedscientist.bsky.social @somavallyd.bsky.social and @lucatroman.bsky.social
Reposted by Matt Johnson ❄️🔬🦠
The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.
A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry
Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...
www.biorxiv.org
September 20, 2025 at 9:29 AM
The outer membrane of Gram-negative bacteria blocks many antibiotics. Our latest work reveals that L-type pyocins bypass this barrier by inactivating the BAM complex, killing Pseudomonas aeruginosa without entering the cell, providing a new blueprint for beating antibiotic resistance.
Reposted by Matt Johnson ❄️🔬🦠
Story on our Asgard microtubule paper by Nikki Greenwood: www.quantamagazine.org/tiny-tubes-r...
Thanks to all interviewees🎤
Thanks to all interviewees🎤
Tiny Tubes Reveal Clues to the Evolution of Complex Life | Quanta Magazine
Scientists have identified tubulin structures in primitive Asgard archea that may have been the precursor of our own cellular skeletons.
www.quantamagazine.org
September 10, 2025 at 7:07 AM
Story on our Asgard microtubule paper by Nikki Greenwood: www.quantamagazine.org/tiny-tubes-r...
Thanks to all interviewees🎤
Thanks to all interviewees🎤
Reposted by Matt Johnson ❄️🔬🦠
We recently discovered a brand-new (and unique!) anti-phage defense system in bacteria. Check out this Pursuit article from @Melbourne University featuring our recent work. Terrific effort from our PhD student Somavally!
lnkd.in/geXUApmK
lnkd.in/geXUApmK
September 10, 2025 at 2:23 PM
We recently discovered a brand-new (and unique!) anti-phage defense system in bacteria. Check out this Pursuit article from @Melbourne University featuring our recent work. Terrific effort from our PhD student Somavally!
lnkd.in/geXUApmK
lnkd.in/geXUApmK
Reposted by Matt Johnson ❄️🔬🦠
We are excited to share our new study which talks about the unique anti-phage system. Please check out the article for more details. Thank you Debnath Ghosal and Sigal Ben Yehuda for this amazing opportunity. Thank you University of Melbourne and Pursuit team!
We recently discovered a brand-new (and unique!) anti-phage defense system in bacteria. Check out this Pursuit article from @Melbourne University featuring our recent work. Terrific effort from our PhD student Somavally!
lnkd.in/geXUApmK
lnkd.in/geXUApmK
September 11, 2025 at 3:14 AM
We are excited to share our new study which talks about the unique anti-phage system. Please check out the article for more details. Thank you Debnath Ghosal and Sigal Ben Yehuda for this amazing opportunity. Thank you University of Melbourne and Pursuit team!
Reposted by Matt Johnson ❄️🔬🦠
📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
August 2, 2025 at 3:01 PM
📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬
Reposted by Matt Johnson ❄️🔬🦠
An Asgard archaeon from a modern analog of ancient microbial mats https://www.biorxiv.org/content/10.1101/2025.07.22.663070v1
July 23, 2025 at 7:18 AM
An Asgard archaeon from a modern analog of ancient microbial mats https://www.biorxiv.org/content/10.1101/2025.07.22.663070v1
Reposted by Matt Johnson ❄️🔬🦠
Excited to share that our work on a family of pore-forming proteins is now live in Science Advances! We show structural snapshots across the entire pore-forming pathway for a cholesterol-dependent cytolysin-like (CDCL) bicomponent system.
March 30, 2025 at 10:50 AM
Excited to share that our work on a family of pore-forming proteins is now live in Science Advances! We show structural snapshots across the entire pore-forming pathway for a cholesterol-dependent cytolysin-like (CDCL) bicomponent system.
Reposted by Matt Johnson ❄️🔬🦠
Fabulous collaboration with Steve Petrovski lab at La Trobe University. Amazing team that made this happen @tiltedscientist.bsky.social, JaysonRose, MiladReyhani, @unimelb, @FMDHS, @ccemmp-outreach.bsky.social.
March 29, 2025 at 1:26 PM
Fabulous collaboration with Steve Petrovski lab at La Trobe University. Amazing team that made this happen @tiltedscientist.bsky.social, JaysonRose, MiladReyhani, @unimelb, @FMDHS, @ccemmp-outreach.bsky.social.
Reposted by Matt Johnson ❄️🔬🦠
Delighted to share our recent work in Nat Comms. This is a "Story of a dwarf predator"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 29, 2025 at 1:26 PM
Delighted to share our recent work in Nat Comms. This is a "Story of a dwarf predator"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Matt Johnson ❄️🔬🦠
I am very happy to announce that we solved the in-virus #cryoEM structure of the #HIV matrix protein. The structure helped us to resolve a long mystery in HIV biology. A🧵1/5
Read more in Nature: www.nature.com/articles/s41... 🧪
Read more in Nature: www.nature.com/articles/s41... 🧪
March 3, 2025 at 6:57 PM
I am very happy to announce that we solved the in-virus #cryoEM structure of the #HIV matrix protein. The structure helped us to resolve a long mystery in HIV biology. A🧵1/5
Read more in Nature: www.nature.com/articles/s41... 🧪
Read more in Nature: www.nature.com/articles/s41... 🧪
Oh this is me, hello bsky!
Mutations in Gordonia amarae mycolic acid biosynthetic pathway confer resistance to Patescibacteria parasite Mycosynbacter amalyticus pubmed.ncbi.nlm.nih.gov/40038264/ #cryoem
March 6, 2025 at 5:27 AM
Oh this is me, hello bsky!