Thomas Bienvenu
@thomasbienvenu.bsky.social
Psychiatrist & Neuroscientist
Humbling reminder of the fact that BOLD =/= spiking
Psychedelics alter neurovascular coupling, which means we need to critically re-evaluate fMRI findings of acute psychedelic effects
#neuroskyence
#PsychSciSky
www.nature.com/articles/s41...
#neuroskyence
#PsychSciSky
www.nature.com/articles/s41...
Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function - Nature Neuroscience
Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI studies of psychedelics.
www.nature.com
October 27, 2025 at 9:10 PM
Humbling reminder of the fact that BOLD =/= spiking
Reposted by Thomas Bienvenu
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
apply.interfolio.com/174756
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
October 14, 2025 at 5:35 PM
During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!
apply.interfolio.com/174756
apply.interfolio.com/174756
Reposted by Thomas Bienvenu
for anyone interested in the amygdala and risky decision-making, check out our new preprint: biorxiv.org/content/10.1...
amygdala neurons track reward-seeking actions, and punishment risk dramatically alters this function. lots of other (BLA-accumbens!) data included.
amygdala neurons track reward-seeking actions, and punishment risk dramatically alters this function. lots of other (BLA-accumbens!) data included.
Risk reshapes amygdala representation of choice
Modifying behavior in response to changing environmental conditions is a crucial adaptive function. This capacity is exemplified when animals curtail pursuit of a valued outcome that risks being punis...
biorxiv.org
October 9, 2025 at 2:01 PM
for anyone interested in the amygdala and risky decision-making, check out our new preprint: biorxiv.org/content/10.1...
amygdala neurons track reward-seeking actions, and punishment risk dramatically alters this function. lots of other (BLA-accumbens!) data included.
amygdala neurons track reward-seeking actions, and punishment risk dramatically alters this function. lots of other (BLA-accumbens!) data included.
Very insightful as usual from @awaisaftab.bsky.social reviewing Elusive cures.
👇One sentence I wish applied to research in 2025 🇫🇷 where 10s of M€ are still being thrown out in dead-end reductionism in a promise to solve things while following the same path.
👇One sentence I wish applied to research in 2025 🇫🇷 where 10s of M€ are still being thrown out in dead-end reductionism in a promise to solve things while following the same path.
Rewriting the Grand Plan of Clinical Neuroscience
A Review of “Elusive Cures: Why Neuroscience Hasn’t Solved Brain Disorders—and How We Can Change That” by Nicole C. Rust ( @nicolecrust.bsky.social )
www.psychiatrymargins.com/p/rewriting-...
A Review of “Elusive Cures: Why Neuroscience Hasn’t Solved Brain Disorders—and How We Can Change That” by Nicole C. Rust ( @nicolecrust.bsky.social )
www.psychiatrymargins.com/p/rewriting-...
Rewriting the Grand Plan of Clinical Neuroscience
A Review of “Elusive Cures” by Nicole C. Rust
www.psychiatrymargins.com
September 21, 2025 at 7:25 AM
Very insightful as usual from @awaisaftab.bsky.social reviewing Elusive cures.
👇One sentence I wish applied to research in 2025 🇫🇷 where 10s of M€ are still being thrown out in dead-end reductionism in a promise to solve things while following the same path.
👇One sentence I wish applied to research in 2025 🇫🇷 where 10s of M€ are still being thrown out in dead-end reductionism in a promise to solve things while following the same path.
Reposted by Thomas Bienvenu
New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
PIEZO channels link mechanical forces to uterine contractions in parturition
Mechanical forces are extensively involved in pregnancy and parturition, but their precise roles and mechanisms remain poorly understood. Here, we identify mechanically activated ion channels PIEZO1 a...
www.biorxiv.org
September 18, 2025 at 3:23 PM
New preprint alert! The uterus expands ~500-fold in pregnancy, yet we know little about how pressures are sensed. Led by @yunxiao-dr.bsky.social, we show PIEZOs are required for contractions and birth in mice, with dual roles of PIEZO1 in muscle and PIEZO2 in neurons
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Thomas Bienvenu
A subset of dorsal raphe dopamine neurons is critical for survival-oriented vigilance. https://www.biorxiv.org/content/10.1101/2025.03.31.646345v1
April 1, 2025 at 8:16 AM
A subset of dorsal raphe dopamine neurons is critical for survival-oriented vigilance. https://www.biorxiv.org/content/10.1101/2025.03.31.646345v1
This!... + perhaps the financial illness goes beyond bullshit jobs & tasks, to encompass the for-profit obsession of public institutions and the idea that we must prepare students for the private market.
We are failing ourselves so badly by losing focus of our core missions
We are failing ourselves so badly by losing focus of our core missions
Why academia is sleepwalking into self-destruction. My editorial @brain1878.bsky.social If you agree with the sentiments please repost. It's important for all our sakes to stop the madness
academic.oup.com/brain/articl...
academic.oup.com/brain/articl...
March 7, 2025 at 9:13 AM
This!... + perhaps the financial illness goes beyond bullshit jobs & tasks, to encompass the for-profit obsession of public institutions and the idea that we must prepare students for the private market.
We are failing ourselves so badly by losing focus of our core missions
We are failing ourselves so badly by losing focus of our core missions