Shreyas Pai
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theshreyaspai.bsky.social
Shreyas Pai
@theshreyaspai.bsky.social
Systems Biology PhD Student @Harvard, Labs of Michael Desai @mmdesai.bsky.social & Michael Baym @baym.lol | Trinity College Cambridge Alum | Evolution & Microbes
April 2, 2025 at 6:59 PM
Thanks again to everyone involved in this project! Parris Humphrey, Camille Simonet, Katya Kosheleva, & Anurag Limdi, under the awesome mentorship of Michael Desai. We’d all love to hear your thoughts on the preprint!
April 2, 2025 at 6:59 PM
Overall, sex decreases the pleiotropic costs of adaptation by purging linked genetic load. Sex thus makes generalism less costly and allows populations to endure environmental change. (10/n)
April 2, 2025 at 6:59 PM
This crucially depends on the genetic architecture of pleiotropic fitness tradeoffs and local adaptation. In our system, in agreement with most studies of natural populations, local adaptation is generated by ‘mutation accumulation’ rather than ‘antagonistic pleiotropy’. (9/n)
April 2, 2025 at 6:59 PM