Shreyas Pai
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theshreyaspai.bsky.social
Shreyas Pai
@theshreyaspai.bsky.social
Systems Biology PhD Student @Harvard, Labs of Michael Desai @mmdesai.bsky.social & Michael Baym @baym.lol | Trinity College Cambridge Alum | Evolution & Microbes
Super excited to be talking at Pint of Science next week! Alongside my incredibly talented friend and fellow evolutionary biologist Rishabh Kapoor!
May 16, 2025 at 2:08 AM
Backcrossing evolved clones to their ancestors suggests that a single round of sex can purge this deleterious load in asexuals. (8/n)
April 2, 2025 at 6:59 PM
This excess hitchhiking genetic load in asexuals underlies their decreased fitness in alternate environments. (7/n)
April 2, 2025 at 6:59 PM
By sequencing clones from these populations, we find that sex narrows the outcomes of molecular evolution: sexuals have fewer functional mutations and fewer mutational targets, but a higher proportion of these are ‘multi-hit’ and likely adaptive. (6/n)
April 2, 2025 at 6:59 PM
Sex increases the rate and repeatability of adaptive evolution locally, while simultaneously alleviating its fitness costs in these alternate environments. (5/n)
April 2, 2025 at 6:59 PM