🧵(1/4) For the first half of October 2025 we have 3 publications from the CIRTN labs🍁. These papers are from the groups of Drs. Bruce Verchere, Yi-Chun Chen, Francis Lynn, James Shapiro, Tatsuya Kin and Guy Rutter!

🧵(5/7) Here are the publications from the 2nd half of Sept.2025
From Dr. Patrick MacDonald
"Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes” PMID: 41026524
www.jci.org/articles/vie...

🧵(1/7)We are now out of September🍁! From the last two weeks we have had publications from the CIRTN labs of Drs Jenny Bruin, Mourad Ferdaoussi, Peter Light, Patrick MacDonald, James Shapiro and Bruce Verchere!

Novel insights into the molecular underpinnings of islet cell dysfunction in #T1D highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity @bcellorg.bsky.social www.jci.org/articles/vie...

Yesterday we celebrated our 600th human research islet isolation in support of diabetes research (and then last night isolated the islets in the pic). I’m very fortunate to work with such a dedicated team! See more at www.isletcore.ca

🧵(3/3) Cont' beginning of Sept 2025:
1) www.cell.com/cell-stem-ce...
2) academic.oup.com/edrv/advance...
3) www.nature.com/articles/s41...

🧵(2/3) Cont' beginning of Sept 2025:
2) “Glycerol and glycerol-3-phosphate: multifaceted metabolites in metabolism, cancer and other diseases” PMID: 40927981
3) “Osteocalcin has many tricks to get γ-carboxylated” PMID: 40913186
Links in last thread

🧵(1/3) Our first post highlighting publications coming from CIRTN groups (first half of September 2025)! We have works from the labs of Drs. Marc Prentki, Timothy Kieffer and Mathieu Ferron.
1)“From β soloist to endocrine symphony: Subtype-complete islets conduct glucose harmony” PMID 40912231

Hello! Welcome to the CIRTN-R2FIC BlueSky account! Our group focuses on researching pancreatic islet biology and pathology related to islets such as type 1 and type 2 diabetes.
Here you will find bi-weekly updates from the scientists from across Canada that make up CIRTN-R2FIC.

🔬 How do molecular pathways drive islet dysfunction in T1D? 🔬Join to explores islet cell dysfunction in human T1D.

📝 Register: us02web.zoom.us/meeting/regi...

#DiabetesResearch #T1D #IsletBiology #MolecularPathways #BetaCells #Bioinformatics #Autoimmunity #Endocrinology

We link molecular and functional phenotypes of islet cells from donors with type 1 diabetes to understand impaired insulin and glucagon secretion. Immune signalling, nuclear exclusion, mTOR and lysosomes in alpha cell dysfunction.

https://www.biorxiv.org/content/10.1101/2025.02.20.639325v1