Theo Mantamadiotis
@theo-braincan-lab.bsky.social
Head Brain Cancer Biol Lab | Assoc/Prof@UMelb 🇦🇺 Former Marie-Curie Fellow@UPatras 🇬🇷 DKFZ Connect 🇩🇪
Editorial board: Carcinogenesis (OUP) | Brain | Cancer | Signaling | CREB | Transcription | TME | Spatial Biol
https://shorturl.at/atRwp
Editorial board: Carcinogenesis (OUP) | Brain | Cancer | Signaling | CREB | Transcription | TME | Spatial Biol
https://shorturl.at/atRwp
Reposted by Theo Mantamadiotis
ONLINE NOW: Special Issue on Radiation, Humanity, and Hope: 80 Years of Cancer Research Post-Hiroshima and Nagasaki
academic.oup.com/carcin/issue...
academic.oup.com/carcin/issue...
November 11, 2025 at 5:08 AM
ONLINE NOW: Special Issue on Radiation, Humanity, and Hope: 80 Years of Cancer Research Post-Hiroshima and Nagasaki
academic.oup.com/carcin/issue...
academic.oup.com/carcin/issue...
Reposted by Theo Mantamadiotis
Eighty years of cancer research after the atomic bombings of Hiroshima and Nagasaki
doi.org/10.1093/carc...
doi.org/10.1093/carc...
November 11, 2025 at 5:12 AM
Eighty years of cancer research after the atomic bombings of Hiroshima and Nagasaki
doi.org/10.1093/carc...
doi.org/10.1093/carc...
Reposted by Theo Mantamadiotis
Nobel laureate, molecular biologist & cancer researcher, David Baltimore, died at he age of 87.
shorturl.at/2t7Ya
In 1975, he shared the Nobel Prize in Physiology or Medicine for discovering reverse transcriptase, challenging the view that genetic information was only transferred from DNA to RNA
shorturl.at/2t7Ya
In 1975, he shared the Nobel Prize in Physiology or Medicine for discovering reverse transcriptase, challenging the view that genetic information was only transferred from DNA to RNA
September 8, 2025 at 7:06 AM
Nobel laureate, molecular biologist & cancer researcher, David Baltimore, died at he age of 87.
shorturl.at/2t7Ya
In 1975, he shared the Nobel Prize in Physiology or Medicine for discovering reverse transcriptase, challenging the view that genetic information was only transferred from DNA to RNA
shorturl.at/2t7Ya
In 1975, he shared the Nobel Prize in Physiology or Medicine for discovering reverse transcriptase, challenging the view that genetic information was only transferred from DNA to RNA
Reposted by Theo Mantamadiotis
Radiation, Humanity, and Hope: 80 Years of Cancer Research Post-Hiroshima & Nagasaki
In September, Carcinogenesis will publish a special issue to commemorate the 80th anniversary of the atomic bombings in Japan, & our understanding of radiation & its impact on human health
academic.oup.com/carcin
In September, Carcinogenesis will publish a special issue to commemorate the 80th anniversary of the atomic bombings in Japan, & our understanding of radiation & its impact on human health
academic.oup.com/carcin
August 12, 2025 at 5:50 AM
Radiation, Humanity, and Hope: 80 Years of Cancer Research Post-Hiroshima & Nagasaki
In September, Carcinogenesis will publish a special issue to commemorate the 80th anniversary of the atomic bombings in Japan, & our understanding of radiation & its impact on human health
academic.oup.com/carcin
In September, Carcinogenesis will publish a special issue to commemorate the 80th anniversary of the atomic bombings in Japan, & our understanding of radiation & its impact on human health
academic.oup.com/carcin
Delighted to present our research at the #Spatial Imaging Workshop, hosted by Biological Optical Microscopy Platform (BOMP) @ The University of Melbourne & supported by Leica Microsystems & Light Microscopy Australia. The multiplex IHC image shows cell signaling activity using phospho-Abs in #GBM
August 4, 2025 at 11:29 AM
I’m delighted to join the Cure Brain Cancer Foundation Scientific Advisory Committee & look forward to working with the CBCF, consumer advocates & researchers, to advance our understanding of the mechanisms underpinning brain cancer, to ultimately help patients and their families.
March 5, 2025 at 5:25 AM
I’m delighted to join the Cure Brain Cancer Foundation Scientific Advisory Committee & look forward to working with the CBCF, consumer advocates & researchers, to advance our understanding of the mechanisms underpinning brain cancer, to ultimately help patients and their families.
Multiomics Blueprint of Extreme Human Lifespan: “The picture…emerges…that extremely advanced age & poor health are not intrinsically linked & that both processes can be distinguished & dissected at the molecular level”
Santos-Pujol et al., doi.org/10.1101/2025...
Santos-Pujol et al., doi.org/10.1101/2025...
February 26, 2025 at 6:45 AM
Multiomics Blueprint of Extreme Human Lifespan: “The picture…emerges…that extremely advanced age & poor health are not intrinsically linked & that both processes can be distinguished & dissected at the molecular level”
Santos-Pujol et al., doi.org/10.1101/2025...
Santos-Pujol et al., doi.org/10.1101/2025...
Reposted by Theo Mantamadiotis
🚀 New publication! We developed a PTPRZ1-specific TCR-T cell therapy for glioblastoma.
🔬 Key findings:
✅ Identified a PTPRZ1-reactive TCR from a vaccinated patient
✅ Kills glioblastoma cells with no off-target effects
✅ Eliminates tumors in murine brain models
🔗 www.nature.com/articles/s41...
🔬 Key findings:
✅ Identified a PTPRZ1-reactive TCR from a vaccinated patient
✅ Kills glioblastoma cells with no off-target effects
✅ Eliminates tumors in murine brain models
🔗 www.nature.com/articles/s41...
Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen - Nature Communications
Vaccination in glioblastomas does lead to the emergence of tumour-antigen-specific T cells but T cell dysfunction, poor tumour infiltration and persistence hinder efficient tumour killing. Here author...
www.nature.com
February 11, 2025 at 11:29 AM
🚀 New publication! We developed a PTPRZ1-specific TCR-T cell therapy for glioblastoma.
🔬 Key findings:
✅ Identified a PTPRZ1-reactive TCR from a vaccinated patient
✅ Kills glioblastoma cells with no off-target effects
✅ Eliminates tumors in murine brain models
🔗 www.nature.com/articles/s41...
🔬 Key findings:
✅ Identified a PTPRZ1-reactive TCR from a vaccinated patient
✅ Kills glioblastoma cells with no off-target effects
✅ Eliminates tumors in murine brain models
🔗 www.nature.com/articles/s41...
The University of Melbourne, Brownless Biomedical Library this morning & as it was: For me, it was the place to leaf through the latest hardcopy journal issues on the display stands, or search the journal archives for that elusive article required for my thesis
February 4, 2025 at 3:48 AM
The University of Melbourne, Brownless Biomedical Library this morning & as it was: For me, it was the place to leaf through the latest hardcopy journal issues on the display stands, or search the journal archives for that elusive article required for my thesis
#GBM #TME #spatial analysis: incredible #cellsignaling heterogeneity at single cell resolution, predicts cell function. Differential PI3K-MAPK-CREB pathway activation/co-activation correlates with proliferation, cell density, angiogenesis & proximity to ECM-rich stroma: see go.unimelb.edu.au/52z8
February 1, 2025 at 4:15 AM
#GBM #TME #spatial analysis: incredible #cellsignaling heterogeneity at single cell resolution, predicts cell function. Differential PI3K-MAPK-CREB pathway activation/co-activation correlates with proliferation, cell density, angiogenesis & proximity to ECM-rich stroma: see go.unimelb.edu.au/52z8
While updating my CV for another grant application, I am yet again amused by the title of our review article (PDF version), from 2011 (the title is correct on PubMed & the journal web site). I never followed up to fix this because it's great as it i; at the cutting edge of science & mythology:
February 1, 2025 at 3:41 AM
While updating my CV for another grant application, I am yet again amused by the title of our review article (PDF version), from 2011 (the title is correct on PubMed & the journal web site). I never followed up to fix this because it's great as it i; at the cutting edge of science & mythology:
Reposted by Theo Mantamadiotis
Reposted by Theo Mantamadiotis
Bilingualism is associated with a bigger brain. Similar to other cognitively demanding skills, it leads to dynamic subcortical structural adaptations which can be nonlinear, in line with expansion-renormalisation models of experience-dependent neuroplasticity. www.nature.com/articles/s41...
Dynamic effects of bilingualism on brain structure map onto general principles of experience-based neuroplasticity - Scientific Reports
Scientific Reports - Dynamic effects of bilingualism on brain structure map onto general principles of experience-based neuroplasticity
www.nature.com
January 24, 2025 at 4:44 AM
Bilingualism is associated with a bigger brain. Similar to other cognitively demanding skills, it leads to dynamic subcortical structural adaptations which can be nonlinear, in line with expansion-renormalisation models of experience-dependent neuroplasticity. www.nature.com/articles/s41...
Reposted by Theo Mantamadiotis
Great story; Gliomagenesis mimics an injury response orchestrated by neural crest-like cells www.nature.com/articles/s41...
Gliomagenesis mimics an injury response orchestrated by neural crest-like cells - Nature
A study using glioblastoma mouse models, serial magnetic resonance imaging and single-cell profiling details changes in the identity and balance of cellular states from initiation of tumorigenesis to ...
www.nature.com
January 3, 2025 at 4:28 AM
Great story; Gliomagenesis mimics an injury response orchestrated by neural crest-like cells www.nature.com/articles/s41...
Fascinating study!
Why can a human tolerate a drug that globally inhibits transcription? Why do transcription inhibitors not cure cancer? Our first paper of 2025 may help explain (some) of this!
So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work!
www.cell.com/molecular-ce...
So incredibly proud of @tobiaswilliams.bsky.social & Ewa Michalak who led the work!
www.cell.com/molecular-ce...
mRNA export factors store nascent transcripts within nuclear speckles as an adaptive response to transient global inhibition of transcription
Transcription inhibitors also disrupt nuclear export. Here, Williams et al. reveal that mRNA export factors sense transcription inhibition and adapt by storing mature export-competent mRNA in nuclear speckles. This enables rapid release when transcription resumes and ensures retention of cellular identity and viability during a transient global transcription insult.
www.cell.com
January 3, 2025 at 12:16 AM
Fascinating study!
Merry Christmas!
Καλά Χριστούγεννα!
Frohe Weihnachten!
Καλά Χριστούγεννα!
Frohe Weihnachten!
December 24, 2024 at 9:27 AM
Merry Christmas!
Καλά Χριστούγεννα!
Frohe Weihnachten!
Καλά Χριστούγεννα!
Frohe Weihnachten!
Unraveling the functional complexity of the tumor microenvironment via #spatialbiology. The 2 images show rGBM tissue with cell signaling cell plot (left) & cell-type mIHC (right). Neoplastic, vascular & immune cells show distinct signals which correlate with cell clustering & proximity to ECM
December 18, 2024 at 9:31 AM
Unraveling the functional complexity of the tumor microenvironment via #spatialbiology. The 2 images show rGBM tissue with cell signaling cell plot (left) & cell-type mIHC (right). Neoplastic, vascular & immune cells show distinct signals which correlate with cell clustering & proximity to ECM
In Carcinogenesis: shorturl.at/6pvy6 Male mice with nestin-targeted PI3K & PTEN mutations develop tumors which resemble an aggressive form of sex cord stromal tumors. We describe the cell-of-origin, the complex histopathology & using #spatialbiology, the immune cell infiltration of this rare cancer
December 16, 2024 at 6:17 AM
In Carcinogenesis: shorturl.at/6pvy6 Male mice with nestin-targeted PI3K & PTEN mutations develop tumors which resemble an aggressive form of sex cord stromal tumors. We describe the cell-of-origin, the complex histopathology & using #spatialbiology, the immune cell infiltration of this rare cancer
Well done Samuel! Last week, Samuel Widodo submitted his PhD thesis: "Signalling and Transcriptional Regulation of Tumour Associated Macrophage Polarisation in Brain Cancer" @UniMelb & has published 12 papers, so far, with some shown here. #glioblastoma #GBM #spatialbiology #OMICS #macrophages
December 1, 2024 at 5:48 AM
Well done Samuel! Last week, Samuel Widodo submitted his PhD thesis: "Signalling and Transcriptional Regulation of Tumour Associated Macrophage Polarisation in Brain Cancer" @UniMelb & has published 12 papers, so far, with some shown here. #glioblastoma #GBM #spatialbiology #OMICS #macrophages
Reposted by Theo Mantamadiotis
Amazing: 3D organ-wide spatial analysis. (Almost) all of it: real-time methods for 4D analysis next? www.science.org/doi/10.1126/...
Whole-brain spatial transcriptional analysis at cellular resolution
Recent advances in RNA analysis have deepened our understanding of cellular states in biological tissues. However, a substantial gap remains in integrating RNA expression data with spatial context acr...
www.science.org
November 23, 2024 at 12:08 PM
Amazing: 3D organ-wide spatial analysis. (Almost) all of it: real-time methods for 4D analysis next? www.science.org/doi/10.1126/...
Mice with an inducible nestin-CreER transgene targeting PI3K & PTEN develop aggressive brain tumors doi.org/10.1093/neuo... ~20% of the mice also show tumours affecting the reproductive organs. Using #spatialbiology we describe the testis tumors, in the bioRxiv pre-print: doi.org/10.1101/2024...
November 24, 2024 at 9:27 AM
Mice with an inducible nestin-CreER transgene targeting PI3K & PTEN develop aggressive brain tumors doi.org/10.1093/neuo... ~20% of the mice also show tumours affecting the reproductive organs. Using #spatialbiology we describe the testis tumors, in the bioRxiv pre-print: doi.org/10.1101/2024...
To learn about #braincancer & the innovative use of mIHC #spatialbiology tech to understand key molecular & cellular mechanisms regulating the #tumormicroenvironment, go to: shorturl.at/Nafcw #GBM #brain #cancer
November 24, 2024 at 2:04 AM
To learn about #braincancer & the innovative use of mIHC #spatialbiology tech to understand key molecular & cellular mechanisms regulating the #tumormicroenvironment, go to: shorturl.at/Nafcw #GBM #brain #cancer
1st Bsky post pushed from you know where - Following several presentations on how we use #spatialbiology to investigate the #immunology of #braincancer - also see our recent review on this topic shorturl.at/7pwV1
November 23, 2024 at 8:54 PM
1st Bsky post pushed from you know where - Following several presentations on how we use #spatialbiology to investigate the #immunology of #braincancer - also see our recent review on this topic shorturl.at/7pwV1