#bioinformatics #rnavirus #virology

+ all kinds of EVEs in arthropods! I also found a bunch of viral pathogens mislabelled as bacterial and explored "near miss" proteins - with probably coincidental similarity to RdRp. 5/5

I love EVEs so I spent time exploring and found orbivirus like EVEs in nematodes which pre-date species divergence and with a likely infectious counterpart, loads of diverse mitovirus-like regions in plants, and the first EVEs in the Perkinozoa phylum of protists 4/5

Initially I wanted to explore how complicated it is to use database proteins as a negative control when looking for viruses because so many are unlabelled viral sequences. But then I unexpectedly found hundreds of RdRp-like endogenous viral elements 3/5

I dug into proteins labelled as e.g. "unchacterised protein", "hypothetical protein" without any named function from any species in the NCBI protein and UniProt databases to find proteins related to RdRp 2/5

I translated "Jeff Jet: Abenteuer InfoHighway" as "Jeff Jet: Adventure on the InfoHighway" archive.org/details/jeff... - a German promotional adventure game for Hewlett Packard from 1995.

You ring the doorbell on Oncology, just show any card, they won't check, then go down two floors in the lift, around the corner and then up one floor, once you get outside climb over the fence, scrabble up the verge, sign in as a visitor and you're there.

It's the same in the UK. They specialise in roads which look like they link together but there's a huge fence or mysterious ditch blocking the way, or they've joined two buildings across the gap but not added a door to let people through.

Thank you! This is amazing.

And the same colour!