One of the really nice parts of COVID was how research was being disseminated. Lots of small bite sized research published in preprints/blogs/etc that was easy to review. It was a glimpse into another way and I found it far more engaging.

Given the lack of any traffic enforcement I'm pretty sure Boston doesn't give a shit any ticket based revenue unless it's street cleaning.

I'm upset this doesn't do my taxes

You also get the reverse of this where samples with different vasculature (tumor-normal) report whatever is enriched in blood as biomarkers. Mir21 is a popular one.

I think pure scale is often misguided as well simply from a waste stream/consumable point of view. Cool, your small lab now has to deal with an Olympic sized pool of biological waste every day. Do more pooled stuff, then deconvolute in arrays. Which also doesn't require extensive automation.

Keep it all pooled and separate winners in a pooled screen.

I'd actually love to see what your claude.md file looks like. I poked around that ai fix you published in minijinja but couldn't find a copy of your instruction file.

You can’t eat microchips. Social media can’t heal the sick. B2B SaaS will never love you

The final measure of any technology is the value it creates, directly or indirectly, for living things. In this sense, biology is everyone’s mission

I think when someone comes out with an orchestration engine where the local and production experience are similar it'll quickly replace k8s. That was the initial great part of docker + compose but now we're at a place where an entire separate stack exists that only runs in some cloud.

I have also loaded human samples (HG00096 from 1000G) into this viewer, which while wildly impractical is nice to know it can handle it.

SAM/BAM is probably the best exception to the viable text based format I can think of (even fasta has a litany of broken readers/writers). Maybe it's because its complex enough nobody wants to make their own writer, but harmless enough to awk/etc. the output.

I've been working more with sqlite these days and keep thinking about how many problems may have been avoided if GFF/GTF or GFA started as a sqlite schema. That way the community could actually carry out schema/data migrations of changes instead of having 10s of versions with slight differences.

Encoding genomes to midi files is this year's lofi beats.

🐉