Tetsuhisa Otani
@tetsuotani.bsky.social
Cell biologist interested in cell-cell junctions and epithelial biology. Associate professor at Tokyo Metropolitan University.
These results suggested that the ‘loser’ cells are eliminated by mechanical compression. Indeed, when we modified the coculture ratio, we found that ZO-1/ZO-2 double KO cells (magenta) needed to be surrounded by normal cells (green) to be eliminated. (9/n)
January 14, 2025 at 10:26 AM
These results suggested that the ‘loser’ cells are eliminated by mechanical compression. Indeed, when we modified the coculture ratio, we found that ZO-1/ZO-2 double KO cells (magenta) needed to be surrounded by normal cells (green) to be eliminated. (9/n)
ROCK was required to form supracellular actomyosin cables formed in the normal cells at the clone boundary. The actomyosin cables constricted in a purse-string-like manner to eliminate ZO-1/ZO-2 double KO cells. (8/n)
January 14, 2025 at 10:26 AM
ROCK was required to form supracellular actomyosin cables formed in the normal cells at the clone boundary. The actomyosin cables constricted in a purse-string-like manner to eliminate ZO-1/ZO-2 double KO cells. (8/n)