Tetsuhisa Otani
@tetsuotani.bsky.social
Cell biologist interested in cell-cell junctions and epithelial biology. Associate professor at Tokyo Metropolitan University.
Reposted by Tetsuhisa Otani
Please comment on this! The complexity of living systems cannot be fully recapitulated by in vitro or computational approaches alone. While advances in non-animal model technologies offer complementary tools, they lack the full physiological and developmental context of a living organism.
🧪 After the workshop on 7/7, the FDA and NIH are asking for public comments on implementing novel methodologies and other strategies to reduce the use of animal testing by 7/14:
www.fda.gov/news-events/...
www.fda.gov/news-events/...
FDA-NIH Workshop: Reducing Animal Testing
The FDA is hosting a workshop on reducing animal testing. The workshop is open to current FDA and NIH employees.
www.fda.gov
July 10, 2025 at 10:41 PM
Please comment on this! The complexity of living systems cannot be fully recapitulated by in vitro or computational approaches alone. While advances in non-animal model technologies offer complementary tools, they lack the full physiological and developmental context of a living organism.
New preprint from the lab! We show that epithelial cells lacking ZO-1/ZO-2, the key scaffolding proteins of tight junctions, are eliminated when surrounded by normal cells. (1/n)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Competitive elimination of ZO-1/ZO-2-deficient cells regulates epithelial barrier homeostasis
Epithelia cover the body and form a barrier to segregate the internal body from the external environment. Epithelial tissues contact the external environment and are exposed to various stresses that a...
www.biorxiv.org
January 14, 2025 at 10:26 AM
New preprint from the lab! We show that epithelial cells lacking ZO-1/ZO-2, the key scaffolding proteins of tight junctions, are eliminated when surrounded by normal cells. (1/n)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...