If we can break the "bulletproof" workhorse of research labs, what's happening to your therapeutic proteins?
Your sequence design might be the hidden variable sabotaging your experiments: www.terrain.bio/post/notes-f...
Your sequence design might be the hidden variable sabotaging your experiments: www.terrain.bio/post/notes-f...
Notes from the Lab: I Killed GFP | Terrain Bio
We killed GFP—the most reliable protein in molecular biology. Same amino acid sequence, different mRNA design, zero expression. If we can break the
www.terrain.bio
June 6, 2025 at 5:22 PM
If we can break the "bulletproof" workhorse of research labs, what's happening to your therapeutic proteins?
Your sequence design might be the hidden variable sabotaging your experiments: www.terrain.bio/post/notes-f...
Your sequence design might be the hidden variable sabotaging your experiments: www.terrain.bio/post/notes-f...
Hear what our CSO Aaron Larsen has to say about the state of mRNA sequence design. 👉 www.terrain.bio/post/most-mr...
Most mRNA Design Sucks (And Most Vendors Won't Tell You) | Terrain Bio
Most mRNA sequences in therapeutic development today are fundamentally flawed. And vendors offering 'optimization' services are prioritizing their manufacturing convenience rather than your therapeuti...
www.terrain.bio
April 10, 2025 at 1:41 PM
Hear what our CSO Aaron Larsen has to say about the state of mRNA sequence design. 👉 www.terrain.bio/post/most-mr...
When we analyzed sequences from leading vendors, we found integrity as low as ~50%. After Terrain’s mRNA design & build services, we delivered the correct sequence at >90%.
The difference? The fate of your mRNA therapy.
The difference? The fate of your mRNA therapy.
April 10, 2025 at 1:41 PM
When we analyzed sequences from leading vendors, we found integrity as low as ~50%. After Terrain’s mRNA design & build services, we delivered the correct sequence at >90%.
The difference? The fate of your mRNA therapy.
The difference? The fate of your mRNA therapy.
Read more: www.terrainbiosciences.com/post/bringin...
Bringing sequence design out of the computer | Terrain Bio
www.terrainbiosciences.com
February 25, 2025 at 2:40 PM
Read more: www.terrainbiosciences.com/post/bringin...
Real progress in our ability to design effective RNA medicines will come from tight coupling between computational design and experimental validation – what we call "ex silico" development.
February 25, 2025 at 2:40 PM
Real progress in our ability to design effective RNA medicines will come from tight coupling between computational design and experimental validation – what we call "ex silico" development.
Read more from our scientific co-founders @pdhsu.bsky.social, Jonathan, and Omar: www.terrainbiosciences.com/post/introdu...
A letter from our co-founders: Introducing Terrain Bio | Terrain Bio
Today, we're thrilled to announce Terrain Bio, a company dedicated to accelerating scientific progress by bringing scalable, enabling technologies to every team developing RNA medicines. Our mission i...
www.terrainbiosciences.com
February 12, 2025 at 1:42 PM
Read more from our scientific co-founders @pdhsu.bsky.social, Jonathan, and Omar: www.terrainbiosciences.com/post/introdu...
That’s why Terrain Bio is built on a philosophy more akin to West Coast tech than traditional pharma. We aren’t focused on nurturing our own proprietary pipeline; instead, we’re crafting a product for scientists: better RNA, delivered faster.
February 12, 2025 at 1:42 PM
That’s why Terrain Bio is built on a philosophy more akin to West Coast tech than traditional pharma. We aren’t focused on nurturing our own proprietary pipeline; instead, we’re crafting a product for scientists: better RNA, delivered faster.
In science, as in software, you wouldn’t expect innovators to start from scratch every time. You wouldn’t homebrew your molecular biology kits or train AI models from raw code. Just like in our science, we should be standing on the shoulders of giants.
February 12, 2025 at 1:42 PM
In science, as in software, you wouldn’t expect innovators to start from scratch every time. You wouldn’t homebrew your molecular biology kits or train AI models from raw code. Just like in our science, we should be standing on the shoulders of giants.
mRNA is emerging as a transformative modality, enabling vaccines, gene edits, and more with unprecedented speed. Yet even with so much potential, every new opportunity still demands years and millions of dollars recreating the underlying experimental infrastructure.
February 12, 2025 at 1:42 PM
mRNA is emerging as a transformative modality, enabling vaccines, gene edits, and more with unprecedented speed. Yet even with so much potential, every new opportunity still demands years and millions of dollars recreating the underlying experimental infrastructure.
Our mission is to provide scalable, high-quality infrastructure for designing and delivering RNA that frees researchers developing RNA medicines from reinventing the wheel 🧵
February 12, 2025 at 1:42 PM
Our mission is to provide scalable, high-quality infrastructure for designing and delivering RNA that frees researchers developing RNA medicines from reinventing the wheel 🧵