Tae Gyun Kim
@taegyunkim.bsky.social
PhD Candidate at Tae-Young Yoon Lab,
Seoul National University, South Korea
# Single-molecule Biophysics, Drug Discovery, Biomolecular Condensate, Transcription factor, Cancer and Aging-related Diseases
Seoul National University, South Korea
# Single-molecule Biophysics, Drug Discovery, Biomolecular Condensate, Transcription factor, Cancer and Aging-related Diseases
StealTHY: An immunogen-free CRISPR platform to expose concealed metastasis regulators in immunocompetent models: Cell www.cell.com/cell/fulltex...
StealTHY: An immunogen-free CRISPR platform to expose concealed metastasis regulators in immunocompetent models
By sidestepping Cas9 immunogenicity, the StealTHY CRISPR platform enables immune-compatible
in vivo genetic screens, directly translatable to humanized cancer models. Using this
immune-stealth strateg...
www.cell.com
November 8, 2025 at 8:09 AM
StealTHY: An immunogen-free CRISPR platform to expose concealed metastasis regulators in immunocompetent models: Cell www.cell.com/cell/fulltex...
Phase separation to buffer growth-mediated dilution in synthetic circuits: Cell www.cell.com/cell/fulltex...
Phase separation to buffer growth-mediated dilution in synthetic circuits
Phase separation stabilizes synthetic gene circuits and boosts production under dynamic
growth conditions. By locally concentrating transcription factors at promoters, it
protects gene expression from...
www.cell.com
November 8, 2025 at 8:08 AM
Phase separation to buffer growth-mediated dilution in synthetic circuits: Cell www.cell.com/cell/fulltex...
This paper looks so interesting..!
Direct targeting and regulation of RNA polymerase II by cell signaling kinases | Science www.science.org/doi/10.1126/...
Direct targeting and regulation of RNA polymerase II by cell signaling kinases | Science www.science.org/doi/10.1126/...
Direct targeting and regulation of RNA polymerase II by cell signaling kinases
Distinct phosphorylation marks are placed on the carboxyl-terminal domain (CTD) of RNA polymerase II (Pol II) during different stages of gene transcription. These phospho-CTD marks function as a molec...
www.science.org
November 7, 2025 at 12:13 AM
This paper looks so interesting..!
Direct targeting and regulation of RNA polymerase II by cell signaling kinases | Science www.science.org/doi/10.1126/...
Direct targeting and regulation of RNA polymerase II by cell signaling kinases | Science www.science.org/doi/10.1126/...
Repair of DNA double-strand breaks leaves heritable impairment to genome function | Science www.science.org/doi/10.1126/...
Repair of DNA double-strand breaks leaves heritable impairment to genome function
Upon DNA breakage, a genomic locus undergoes alterations in three-dimensional chromatin architecture to facilitate signaling and repair. Although cells possess mechanisms to repair damaged DNA, it is ...
www.science.org
November 7, 2025 at 12:10 AM
Repair of DNA double-strand breaks leaves heritable impairment to genome function | Science www.science.org/doi/10.1126/...
Reposted by Tae Gyun Kim
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - @distefanolab.bsky.social @brumbaugh-lab.bsky.social go.nature.com/3X215du
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology
Stem cell differentiation is controlled by manipulating RNA condensates.
go.nature.com
October 28, 2025 at 6:50 PM
Selective RNA sequestration in biomolecular condensates directs cell fate transitions - @distefanolab.bsky.social @brumbaugh-lab.bsky.social go.nature.com/3X215du
Secretome translation shaped by lysosomes and lunapark-marked ER junctions | Nature www.nature.com/articles/s41...
Secretome translation shaped by lysosomes and lunapark-marked ER junctions - Nature
Live-cell imaging of mRNA encoding secretome proteins and translated nascent peptide markers show that secretome translation occurs at endoplasmic reticulum junctions near lysosomes, requires lun...
www.nature.com
November 6, 2025 at 2:35 AM
Secretome translation shaped by lysosomes and lunapark-marked ER junctions | Nature www.nature.com/articles/s41...
A unifying model of LAT condensates in reconstitution experiments | bioRxiv www.biorxiv.org/content/10.1...
A unifying model of LAT condensates in reconstitution experiments
The formation of condensates by the Linker for the Activation of T-cells (LAT) is a key signal gating and amplification step in the T-cell receptor signaling pathway. LAT condensation is challenging t...
www.biorxiv.org
November 6, 2025 at 2:11 AM
A unifying model of LAT condensates in reconstitution experiments | bioRxiv www.biorxiv.org/content/10.1...
Generation of antigen-specific paired-chain antibodies using large language models: Cell www.cell.com/cell/fulltex...
Generation of antigen-specific paired-chain antibodies using large language models
MAGE is a sequence-based protein language model designed to generate diverse human
antibody sequences targeting various pathogens, including SARS-CoV-2, H5N1, and RSV-A.
This AI-driven approach addres...
www.cell.com
November 5, 2025 at 8:47 AM
Generation of antigen-specific paired-chain antibodies using large language models: Cell www.cell.com/cell/fulltex...
Reposted by Tae Gyun Kim
(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.
November 4, 2025 at 5:58 PM
(1/10) How do diverse leukemia mutations converge on the same molecular program? In #RibackLab first manuscript @cp-cell.bsky.social, collaboration with @goodell-lab.bsky.social shows that disparate mutations rewire shared protein networks to form nuclear condensates called C-bodies.
Kinase condensates enrich ATP and trigger autophosphorylation www.biorxiv.org/content/bior...
www.biorxiv.org
November 4, 2025 at 1:31 AM
Kinase condensates enrich ATP and trigger autophosphorylation www.biorxiv.org/content/bior...
Condensation-dependent interactome of a chromatin remodeler underlies tumor suppressor activities | Nature Communications www.nature.com/articles/s41...
Condensation-dependent interactome of a chromatin remodeler underlies tumor suppressor activities - Nature Communications
This study reveals how a cancer-associated mutation in CHD1 leads to the loss of its C-terminal intrinsically disordered region, disrupting condensate formation. This impairment causes improper genome...
www.nature.com
November 4, 2025 at 1:31 AM
Condensation-dependent interactome of a chromatin remodeler underlies tumor suppressor activities | Nature Communications www.nature.com/articles/s41...
Evidence for improved DNA repair in long-lived bowhead whale | Nature www.nature.com/articles/s41...
Evidence for improved DNA repair in long-lived bowhead whale - Nature
Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein. &nbs...
www.nature.com
October 30, 2025 at 12:25 AM
Evidence for improved DNA repair in long-lived bowhead whale | Nature www.nature.com/articles/s41...
Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes | Science www.science.org/doi/10.1126/...
Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes
Phenotypic drug screening remains constrained by the vastness of chemical space and technical challenges scaling experimental workflows. To overcome these barriers, computational methods have been dev...
www.science.org
October 24, 2025 at 12:15 AM
Active learning framework leveraging transcriptomics identifies modulators of disease phenotypes | Science www.science.org/doi/10.1126/...
Designing allosteric modulators to change GPCR G protein subtype selectivity | Nature www.nature.com/articles/s41...
Designing allosteric modulators to change GPCR G protein subtype selectivity - Nature
Studies of the G-protein-coupled receptor NTSR1 show that the G protein selectivity of this receptor can be modified by small molecules, enabling the design of drugs that work by switching receptor su...
www.nature.com
October 23, 2025 at 12:25 AM
Designing allosteric modulators to change GPCR G protein subtype selectivity | Nature www.nature.com/articles/s41...
Transcriptional interferences ensure one olfactory receptor per ant neuron | Nature www.nature.com/articles/s41...
Transcriptional interferences ensure one olfactory receptor per ant neuron - Nature
Ants evolved a transcriptional-interference-based mechanism to express a single odorant receptor from an array of Or genes with functionally similar promoters.
www.nature.com
October 23, 2025 at 12:24 AM
Transcriptional interferences ensure one olfactory receptor per ant neuron | Nature www.nature.com/articles/s41...
Asymmetry in hydrophobicity induces electric potential in non-charged protein condensates | bioRxiv www.biorxiv.org/content/10.1...
Asymmetry in hydrophobicity induces electric potential in non-charged protein condensates
The capacity of biomolecular condensates to establish and modulate electrochemical equilibria is emerging as an important functioning mechanism in cellular biochemistry. However, the physical chemistr...
www.biorxiv.org
October 21, 2025 at 12:30 AM
Asymmetry in hydrophobicity induces electric potential in non-charged protein condensates | bioRxiv www.biorxiv.org/content/10.1...
Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq | Nature Genetics www.nature.com/articles/s41...
Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq - Nature Genetics
This study introduces single-cell transcription factor (TF) sequencing, a single-cell barcoded and doxycycline-inducible TF overexpression approach that reveals dose-sensitive functional classes of TF...
www.nature.com
October 20, 2025 at 6:14 AM
Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq | Nature Genetics www.nature.com/articles/s41...
Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq | Nature Genetics www.nature.com/articles/s41...
Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq - Nature Genetics
This study introduces single-cell transcription factor (TF) sequencing, a single-cell barcoded and doxycycline-inducible TF overexpression approach that reveals dose-sensitive functional classes of TF...
www.nature.com
October 20, 2025 at 6:06 AM
Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq | Nature Genetics www.nature.com/articles/s41...
Mesoscale volumetric fluorescence imaging at nanoscale resolution by photochemical sectioning | Science www.science.org/doi/10.1126/...
Mesoscale volumetric fluorescence imaging at nanoscale resolution by photochemical sectioning
Optical nanoscopy of intact biological specimens has been transformed by recent advancements in hydrogel-based tissue clearing and expansion, enabling the imaging of cellular and subcellular structure...
www.science.org
October 17, 2025 at 12:30 AM
Mesoscale volumetric fluorescence imaging at nanoscale resolution by photochemical sectioning | Science www.science.org/doi/10.1126/...
“Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling | Science www.science.org/doi/10.1126/...
“Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling
Synaptic vesicle (SV) exocytosis underpins neuronal communication, yet its nanoscale dynamics remain poorly understood owing to limitations in visualizing rapid events in situ. Here, we used optogenet...
www.science.org
October 17, 2025 at 12:30 AM
“Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling | Science www.science.org/doi/10.1126/...
Co-translational ribosome pairing enables native assembly of misfolding-prone subunits | Nature Communications www.nature.com/articles/s41...
Co-translational ribosome pairing enables native assembly of misfolding-prone subunits - Nature Communications
Protein complexes are essential for cell function. Here, authors show that paired ribosomes can help each other’s nascent chains fold correctly, enabling proper dimer assembly and preventing misfolding, using lamin as a model system.
www.nature.com
October 13, 2025 at 2:14 AM
Co-translational ribosome pairing enables native assembly of misfolding-prone subunits | Nature Communications www.nature.com/articles/s41...
Dual membrane receptor degradation via folate receptor targeting chimera | Nature Communications www.nature.com/articles/s41...
Dual membrane receptor degradation via folate receptor targeting chimera - Nature Communications
This study presents FolTAC-dual, a folate receptor-mediated platform for dual degradation of EGFR/HER2 and PD-L1/VISTA, offering a strategy to overcome drug resistance and enhance antitumor immunity for cancer treatment.
www.nature.com
October 13, 2025 at 2:14 AM
Dual membrane receptor degradation via folate receptor targeting chimera | Nature Communications www.nature.com/articles/s41...
Ddx61-enriched condensates refine heart regeneration programs | Nature Communications www.nature.com/articles/s41...
Ddx61-enriched condensates refine heart regeneration programs - Nature Communications
Pronobis et al. show that Ddx61 localizes to P-bodies and regulates heart muscle proliferation during cardiac regeneration in zebrafish. Ddx61 is required is required to restrain expression of Chordin, a secreted BMP inhibitor that impedes regeneration if present at high levels.
www.nature.com
October 13, 2025 at 12:10 AM
Ddx61-enriched condensates refine heart regeneration programs | Nature Communications www.nature.com/articles/s41...
Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq | Nature Genetics www.nature.com/articles/s41...
Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq - Nature Genetics
This study introduces single-cell transcription factor (TF) sequencing, a single-cell barcoded and doxycycline-inducible TF overexpression approach that reveals dose-sensitive functional classes of TFs and cellular heterogeneity by mapping TF dose-dependent transcriptomic changes during the reprogramming of mouse embryonic multipotent stromal cells.
www.nature.com
October 7, 2025 at 2:08 PM
Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq | Nature Genetics www.nature.com/articles/s41...