A farewell dim sum dinner with my Berkeley crew. On the one hand, I am so excited to start my lab in Austin; on the other, I'm also so thankful for the friends and colleagues who truly helped me feel so at home these last few years 🥲

OFC neurons famously encode value. Does OFC's value code generalize across task-states? Turns out, no! I regressed each neuron's firing rates against value for choices in each state, and then correlated the betas. Most OFC neurons encoded value in only one state! [8/n]

Several lines of evidence suggest HPC is the sender: HPC neurons were phase-locked to the rising phase of theta and single-trial HPC theta amplitude peaks preceded those in OFC. Partial directed coherence models also suggested HPC->OFC directionality. [6/n]

HPC and OFC are strongly connected and next I wanted to see if they communicate. LFP Theta (4-8 Hz) responses were present on every trial and HPC-OFC theta coherence ramps, starting at the state cue and peaking at the choice, suggesting that HPC and OFC are communicating. [5/n]

I found a functional double-dissociation between HPC and OFC: HPC (but not OFC) neurons encode state information as it becomes available and, at the choice, OFC (but not HPC) neurons encode state. In other words, HPC sets the system state that OFC then uses to guide choice. [4/n]

To address this, I recorded from HPC and OFC in two non-human primates (NHPs) performing a state-dependent choice task. On each trial, the NHPs were cued as to which of two value schemes to apply to an array of 8 choice options. The task state changed trial-to-trial. [3/n]