Maja Szymanska-Lejman
@szymanskalejman.bsky.social
Interested in meiotic hotspots, pericentromeres and recombination.
- Postdoc in The Ziolkowski Lab (AMU, Poznan, Poland)
- Postdoc in the IBCh, PAS, Poland
- Postdoc in The Ziolkowski Lab (AMU, Poznan, Poland)
- Postdoc in the IBCh, PAS, Poland
Reposted by Maja Szymanska-Lejman
Breaking genetics news‼️🌱🌽 A natural DNA trick triples recombination in maize. What we first saw in Arabidopsis (@hendersi lab) a decade ago is now confirmed in crops—opening new doors for plant breeding. Published today in Nature Plants! More details 👉 www.nature.com/articles/s41...
Enhancing local meiotic crossovers in Arabidopsis and maize through juxtaposition of heterozygous and homozygous regions - Nature Plants
This study discovered that locally confined DNA differences boost crossover rates in both Arabidopsis and maize, revealing a conserved mechanism that can accelerate plant breeding and trait introgress...
www.nature.com
September 2, 2025 at 10:19 AM
Breaking genetics news‼️🌱🌽 A natural DNA trick triples recombination in maize. What we first saw in Arabidopsis (@hendersi lab) a decade ago is now confirmed in crops—opening new doors for plant breeding. Published today in Nature Plants! More details 👉 www.nature.com/articles/s41...
Reposted by Maja Szymanska-Lejman
‼️Can we tune crossover hotspot activity by targeting chromatin modifiers? Absolutely!💥
Our screen shows dCas9-JMJ14 represses crossovers at targeted sites, while VP64 boosts them!
🧬 Check our new preprint:
www.biorxiv.org/content/10.1...
#meiosis4ever #CRISPR #Arabidopsis
Our screen shows dCas9-JMJ14 represses crossovers at targeted sites, while VP64 boosts them!
🧬 Check our new preprint:
www.biorxiv.org/content/10.1...
#meiosis4ever #CRISPR #Arabidopsis
https://biorxiv.org/content/10.110…
June 28, 2025 at 5:27 PM
‼️Can we tune crossover hotspot activity by targeting chromatin modifiers? Absolutely!💥
Our screen shows dCas9-JMJ14 represses crossovers at targeted sites, while VP64 boosts them!
🧬 Check our new preprint:
www.biorxiv.org/content/10.1...
#meiosis4ever #CRISPR #Arabidopsis
Our screen shows dCas9-JMJ14 represses crossovers at targeted sites, while VP64 boosts them!
🧬 Check our new preprint:
www.biorxiv.org/content/10.1...
#meiosis4ever #CRISPR #Arabidopsis
It was an incredible meeting! Thank you Ula!! I came back with fantastic memories, new ideas and the Prize for the best talk;-)
We had some amazing talks from ECRs at the British Meiosis Meeting with winning talks jointly from Maja Szymanska-Lejman from @piotraz.bsky.social lab and Omar El Tokhy from Martinez-Perez lab with runner up Katie Hodson from @genomedymanics.bsky.social lab #BMM2025 #meiosis4eva
April 1, 2025 at 6:18 PM
It was an incredible meeting! Thank you Ula!! I came back with fantastic memories, new ideas and the Prize for the best talk;-)
Reposted by Maja Szymanska-Lejman
🥳Just published @nature.com. Over 25 years after the discovery of SPO11 as the enzyme responsible for initiating meiotic recombination, we finally succeeded in reconstituting its DNA cleavage activity.🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
SPO11 dimers are sufficient to catalyse DNA double-strand breaks in vitro - Nature
A biochemical system recapitulates the hallmarks of meiotic double-strand break formation, with mouse SPO11 catalysing break formation in the absence of any partners and remaining covalently atta...
www.nature.com
February 19, 2025 at 4:52 PM
🥳Just published @nature.com. Over 25 years after the discovery of SPO11 as the enzyme responsible for initiating meiotic recombination, we finally succeeded in reconstituting its DNA cleavage activity.🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Maja Szymanska-Lejman
Centrophilic retrotransposon integration via CENH3 chromatin in Arabidopsis from Tetsuji Kakutani & colleagues - beautiful insights into control of transposon insertion into the centromeres
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Centrophilic retrotransposon integration via CENH3 chromatin in Arabidopsis - Nature
An Arabidopsis long terminal repeat retrotransposon integrates de novo into regions occupied by centromere-specific histone variant, showing the impact of centromeric chromatin on transposable element...
www.nature.com
January 2, 2025 at 5:24 PM
Centrophilic retrotransposon integration via CENH3 chromatin in Arabidopsis from Tetsuji Kakutani & colleagues - beautiful insights into control of transposon insertion into the centromeres
www.nature.com/articles/s41...
www.nature.com/articles/s41...