Sharma et al. review the regulation and biological functions of apparently ‘futile’ dynamic lipid cycle in regulating whole-body metabolic homeostasis.

Nature Metabolism, Published online: 25 March 2025; doi:10.1038/s42255-025-01266-1Activated brown adipose tissue takes up large amounts of branched-chain amino acids (BCAAs), but their fate remains unclear. We provide evidence of a metabolic link between BCAA catabolism and haem biosynthesis, which supports mitochondrial function and regulates gene expression by influencing the epigenetic landscape of brown adipocytes.

Olefsky, Rohm and Cunha e Rocha provide a concise overview of the role of small extracellular vesicles in metabolic health and discuss their history, role as biomarkers, mechanisms of action and thera...

This authoritative Perspective lays a foundation for the field of obesity research by comparing commonalities and differences between competing models of obesity pathogenesis and by defining terms that are at the core of this discussion.

Zhao, Chai and colleagues. show that proline regulates hepatic gluconeogenesis by modulating mRNA retention in paraspeckle structures, thus contributing to glycaemic control in type 2 diabetes.

Kenny and Scharenberg et al. provide a broad overview of the fundamental aspects of choline metabolism and cellular handling, and how it impacts physiology and pathology.

Nature Metabolism, Published online: 31 January 2025; doi:10.1038/s42255-024-01213-6Adipose-secreted SERPINA3C in exercised dams protects their offspring from high-fat diet-induced metabolic disorders by promoting KLF4-mediated anti-inflammatory effects…