Sunny
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sunnystill.bsky.social
Sunny
@sunnystill.bsky.social
510 followers 1.2K following 170 posts
Mom, Wife, Sister, Friend, Human Being,
Daydreamer, Free Thinker,
Bleeding Heart Blue Dot,
RN/CDCES Diabetes Educator,
Proud Clemson Mom🐾
Accidental Fantasy Football Team Owner
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Reposted by Sunny
kagrox.bsky.social
Hear me out: What if there was a way for ALL corporations to make regular payments of some set percentage of their profits to the Treasury?
August 22, 2025 at 10:35 PM
Reposted by Sunny
iplayguitarbad.bsky.social
Remember, it is the biggest injustice in history to hold J6 insurrectionists accountable for indisputable illegal acts, but prosecuting this guy for a felony is just America first.
August 14, 2025 at 2:08 AM
Reposted by Sunny
welshaspossible.bsky.social
Does she actually mean "tranquilizers" though? Sometimes these things get lost in translation from the original Russian coming in through her earpiece.
July 23, 2025 at 7:47 PM
Reposted by Sunny
vikingtears61.bsky.social
Slowly this country is being transformed into a third world nation.
June 8, 2025 at 5:32 PM
sunnystill.bsky.social
Personal Best in the human race. EQ off the charts...I don't have the confidence to say "the kids are alright", but this one is. :)
May 16, 2025 at 10:32 AM
sunnystill.bsky.social
Oh, that's HER BABY!💕
May 11, 2025 at 10:57 PM
sunnystill.bsky.social
Congratulations to your family! Is she jealous yet???
May 11, 2025 at 10:41 PM
Reposted by Sunny
sailorrooscout.bsky.social
The study has been published in Alzheimer’s & Dementia. YES, it is PEER-REVIEWED.
• alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
• hscnews.unm.edu/news/unm-res...
SUMMARY Researchers have developed a tau-targeting vaccine that could help prevent the progression of Alzheimer's disease by generating a strong immune response against abnormal tau proteins. The vaccine showed effectiveness in mice and non-human primates, prompting researchers to pursue human clinical trials. It targets a specific region of the tau protein, pT181, linked to Alzheimer's-related brain damage and cognitive decline. If successful in humans, this approach could complement or even surpass current therapies that only modestly impact disease progression by targeting amyloid beta. KEY FACTS •Tau-Targeting Vaccine: Generates antibodies against pT181, a hallmark of Alzheimer's pathology. • Strong Immune Response: Proven effective in mice and macaques, with long-lasting immunity. •The vaccine improved memory, reduced brain atrophy, and caused NO major side effects. •Clinical Trials Ahead: Researchers are preparing for Phase I human trials pending funding. ABSTRACT INTRODUCTION Pathological accumulation of tau (pTau) contributes to various tauopathies, including Alzheimer's disease (AD), and correlates with cognitive decline. A rapid surge in tau-targeted approaches via anti-sense oligonucleotides, active/passive immunotherapies suggests that targeting p-Tau is a viable strategy against tauopathies. METHOD We describe a multi-species validation of our previously described Qß virus-like particle (VLP)-based vaccine technology targeting phosphorylated tau on threonine 181 (pT181-Qß). RESULTS Two vaccine doses of pT181-Qß, without any adjuvants, elicited robust antibody responses in two different mouse models of tauopathy (PS19 and hTau) and rhesus macaques. In mouse models, vaccination reduced AT180+ hyperphosphorylated, Sarkosyl insoluble, Gallyas silver positive tau, inflammasomes/ neuroinflammation, and improved recognition memory and motor function without inducing adverse T-cell activation. Anti-pT181 antibodies are reactive to pTau in human AD brains, engage pT181+ tau in human brain lysates, and are central nervous system bioavailable. DISCUSSION Our results suggest the translational utility of pT181-QB against tauopathies. Highlights • Icosahedral display of phosphorylated tau at threonine 181 (pT181) Qß virus-like particle surface ("pT181-Qß" vaccine) induces a robust immune response in mice and in non-human primates (NHPs) • pT181-Qß vaccination reduces pathological tau (pTau) and brain atrophy, and improves memory and motor function in PS19 and hTau mice. • pT181-Qß vaccination-induced immunoglobulin Gs (IgGs) are safe, Th2 skewed (anti-inflammatory), specific to pTau in human AD brain, and efficiently engage pT181 in NHPs and human brain lysate. • pT181+ tau in human plasma correlates with the neurofilament light in subjects with mild cognitive impairment (MCI)-suggesting the presence of pT181-Qß vaccine target in the early disease state. RESEARCH IN CONTEXT Systematic review: A literature review of PubMed and other literature sources suggests that the pathological modifications in tau protein strongly correlate with the cognitive decline in Alzheimer's disease (AD) and related dementias. As such, many pre-clinical and clinical trials have been targeting pathological tau to determine if such an approach benefits patients. Emerging clinical trials using monoclonal antibodies (mAbs) against different regions of tau show positive results in secondary outcomes of cognitive stabilization. Even if the mAb is approved for tau, repeated infusions of mAbs may have compliance issues in elderly patients and short-lived antibody responses upon active immunizations. The relevant citations and clinical trials are included where appropriate. Interpretation: Our study suggests that display of phosphorylated tau (on T181) peptide on the virus-like particles (VLPs) from Qß bacteriophage induced a robust immune response, reduced tau pathology, prevented brain atrophy, and improved memory, and that the immunoglobulin Gs (IgGs) from immunized sera engaged the target in vaccinated non-human primates (rhesus macaques) and human AD brains. Future directions: Targeting pT181-positive tau with pT181-Qß vaccination may in Phase 0/1 clinical trials validate the safety, immunogenicity, and therapeutic efficacy of pT181-Qß vaccination in patients with AD and related tauopathies.
May 5, 2025 at 4:02 PM