I’m so excited about our upcoming collaboration! It’s going to be mito-tastic

Eep @maweigert.bsky.social @jclandoni.bsky.social

A key insight was building temporal information and memory into the ANN architecture. A huge thanks to all, especially our ‘smart’ (in so many ways) partner @maweigert.bsky. We could now detect local depolarization following constriction, using commonly used (bleachy TMRE) fluorescent biosensors.

But what triggers pearling, and how can we make sense of the distinct morphological changes that take place? We pinpoint several perturbations that differentially impact membrane tension, elasticity, or osmotic pressure, and present a unifying framework: t.ly/yTsPr Collab with Calico Labs.

Nucleoids are known to be regularly spaced along mitochondria, important for their inheritance and maintenance of the local proteome. We identified pearling, a Plateau-Rayleigh type instability described since the 1980s, to be responsible: t.ly/KKmGK. Collab with JLS lab @hhmijanelia.bsky.social

This work is very interesting, nice to see cybergenetics spreading beyond systems biology!

Figure description: the indubitable cell-nuclei, partially furnished with nucleoli, are there seen, with isolated small dark granules between them.

We do ExM! Would love to be added, thank you 😁

Hi Beth, nice to see you here — please add me 😁

Please include me, my lab and I are microscopy fanatics 😁

I lack the words to describe the magic!