The established chiral cadherin patch interacts asymmetrically with the contractile ring, likely driving its rightward closure, the first detectable left–right asymmetry in C. elegans.

We showed that both ventral and left–right asymmetric cadherin flows are required to generate a chiral cadherin patch pattern.

We found that cadherin at cell–cell contacts exhibits two distinct flows, such as ventral flow and left–right asymmetric flow, each driven by ECM and RhoA signaling (left movie). The resulting cadherin patch pattern is chiral, meaning it cannot be superimposed on its mirror image