Kenji Sugioka
@sugi05.bsky.social
Cell and developmental biologist / Studying developmental control of cell division using C. elegans. UBC Vancouver https://www.zoology.ubc.ca/~sugioka/
Adding another link. www.cell.com/current-biol... #Devbio
Cadherin flow translates cortical chirality into left-right asymmetric cell division dynamics in Caenorhabditis elegans embryos
Khor et al. show that cadherin, a major adhesion molecule in animals, undergoes sequential
polarized flows in Caenorhabditis elegans embryos. These flows establish a chiral
cell-cell adhesion pattern ...
www.cell.com
October 22, 2025 at 8:59 PM
Adding another link. www.cell.com/current-biol... #Devbio
The work was spearheaded by MSc student Mi Jing Khor, with support from PhD candidate Yuxuan Rain Xiong and undergrad Gagan Sangha.
October 22, 2025 at 5:27 PM
The work was spearheaded by MSc student Mi Jing Khor, with support from PhD candidate Yuxuan Rain Xiong and undergrad Gagan Sangha.
The established chiral cadherin patch interacts asymmetrically with the contractile ring, likely driving its rightward closure, the first detectable left–right asymmetry in C. elegans.
October 22, 2025 at 5:27 PM
The established chiral cadherin patch interacts asymmetrically with the contractile ring, likely driving its rightward closure, the first detectable left–right asymmetry in C. elegans.
We showed that both ventral and left–right asymmetric cadherin flows are required to generate a chiral cadherin patch pattern.
October 22, 2025 at 5:27 PM
We showed that both ventral and left–right asymmetric cadherin flows are required to generate a chiral cadherin patch pattern.
We found that cadherin at cell–cell contacts exhibits two distinct flows, such as ventral flow and left–right asymmetric flow, each driven by ECM and RhoA signaling (left movie). The resulting cadherin patch pattern is chiral, meaning it cannot be superimposed on its mirror image
October 22, 2025 at 5:27 PM
We found that cadherin at cell–cell contacts exhibits two distinct flows, such as ventral flow and left–right asymmetric flow, each driven by ECM and RhoA signaling (left movie). The resulting cadherin patch pattern is chiral, meaning it cannot be superimposed on its mirror image
We used the 2nd mitosis of C. elegans as a model system, which shows both chiral cortical dynamics and L-R asymmetric closure of the contractile ring. Our past study shows that cell adhesion drives asymmetric ring closure in this cell type. www.nature.com/articles/s41...
Contractile ring mechanosensation and its anillin-dependent tuning during early embryogenesis - Nature Communications
Contractile ring formation, positioning, and closure is influenced by tissue mechanics, though how this information is transmitted is unclear. Here they show that Anillin is critical for a mechanosens...
www.nature.com
October 22, 2025 at 5:27 PM
We used the 2nd mitosis of C. elegans as a model system, which shows both chiral cortical dynamics and L-R asymmetric closure of the contractile ring. Our past study shows that cell adhesion drives asymmetric ring closure in this cell type. www.nature.com/articles/s41...