David Gally
@strain9000.bsky.social
E. coli centric microbiologist now heavily into predicting phage efficacy for UTI in dogs & humans plus O157 in cattle using genomes, interaction datasets and machine learning. Have always loved how bacteria generate heterogeneity…..it’s the spice of life.
Certainly from all the E. coli work on type I fimbriae & pap, phase variation (off/on) is controlled by growth conditions which generates certain rates of off/on switching and therefore specific sub-population levels depending on the niche. This variation is incredibly important and understudied…
November 24, 2023 at 9:53 AM
Certainly from all the E. coli work on type I fimbriae & pap, phase variation (off/on) is controlled by growth conditions which generates certain rates of off/on switching and therefore specific sub-population levels depending on the niche. This variation is incredibly important and understudied…
……we then submitted to PNAS in August and been waiting for re 2 for 3 months. So just frustrating as it’s taken us so long to publish. Preprint next week! It’s great there is a similar result and it would be great to meet up and consider where this can go next-we hope the clinic for our canine UTIs
November 23, 2023 at 3:14 PM
……we then submitted to PNAS in August and been waiting for re 2 for 3 months. So just frustrating as it’s taken us so long to publish. Preprint next week! It’s great there is a similar result and it would be great to meet up and consider where this can go next-we hope the clinic for our canine UTIs
Aude, it’s lovely work as I stated on X/Twitter, just frustrated as we have been in this space for >5 years but not published, O157 data to start, but held back, then the last 2.5 years generating interaction datasets for UTI coli (314) & 31 phage. ML predictions work well and effective cocktails
November 23, 2023 at 3:09 PM
Aude, it’s lovely work as I stated on X/Twitter, just frustrated as we have been in this space for >5 years but not published, O157 data to start, but held back, then the last 2.5 years generating interaction datasets for UTI coli (314) & 31 phage. ML predictions work well and effective cocktails
There is our error - but we will pre-print now - it vindicates the approach though - just less of a splash - c’est la vie….
November 23, 2023 at 8:53 AM
There is our error - but we will pre-print now - it vindicates the approach though - just less of a splash - c’est la vie….
I find this really frustrating as we have had a very similar concept in review at PNAS for 3.5 months with the second review not completed for most of that period. Conspiracy theory I know……..
November 23, 2023 at 7:40 AM
I find this really frustrating as we have had a very similar concept in review at PNAS for 3.5 months with the second review not completed for most of that period. Conspiracy theory I know……..