Cynthia St. Hilaire, PhD, FAHA
@sthilaire.bsky.social
Vascular Biologist and Associate Professor at the @pittdeptofmed.bsky.social. Associate Editor at @ahajournals.bsky.social Circulation Research and host of the podcast #DiscoverCircRes.
I'm so happy/relieved about this!
November 7, 2025 at 4:16 PM
I'm so happy/relieved about this!
Pope Macaron V
May 9, 2025 at 12:58 AM
Pope Macaron V
Thanks for posting us 😁
May 8, 2025 at 7:28 PM
Thanks for posting us 😁
I am hearing from colleagues that universities (not just the ones in the news) are not receiving payments for spending on active grants - have you heard anything on this?
May 2, 2025 at 4:36 PM
I am hearing from colleagues that universities (not just the ones in the news) are not receiving payments for spending on active grants - have you heard anything on this?
Yes, follow me then I can DM you
April 24, 2025 at 2:45 AM
Yes, follow me then I can DM you
Gemini produced a detailed comment that I am happy to share. DM or email me.
April 23, 2025 at 8:09 PM
Gemini produced a detailed comment that I am happy to share. DM or email me.
and (5) a conclusion which recaps your main argument and lists your recommendations again
April 23, 2025 at 8:09 PM
and (5) a conclusion which recaps your main argument and lists your recommendations again
(4) recommendations describing your suggestions to the agency and identifying specific changes you would advise—for example, providing a different way of addressing the problem the agency may not have considered;
April 23, 2025 at 8:09 PM
(4) recommendations describing your suggestions to the agency and identifying specific changes you would advise—for example, providing a different way of addressing the problem the agency may not have considered;
for example, how the action impacts you and what you care about; whether the agency anticipated or estimated these impacts correctly; any unintended consequences of this approach that the agency did not consider; and what additional details from the agency would help you better understand the action
April 23, 2025 at 8:09 PM
for example, how the action impacts you and what you care about; whether the agency anticipated or estimated these impacts correctly; any unintended consequences of this approach that the agency did not consider; and what additional details from the agency would help you better understand the action
(2) a background section where you clearly identify the relevant part of the regulation you are commenting on; (3) analysis that lays out your argument and evidence (including with clear citations to any helpful research)
April 23, 2025 at 8:09 PM
(2) a background section where you clearly identify the relevant part of the regulation you are commenting on; (3) analysis that lays out your argument and evidence (including with clear citations to any helpful research)
How to Make Your Comments Effective Effective
public comments often have one or more of the following characteristics: (1) an introduction where you explain why you are interested in the regulation and highlight any experience with the subject of the rule that may distinguish your comment;
public comments often have one or more of the following characteristics: (1) an introduction where you explain why you are interested in the regulation and highlight any experience with the subject of the rule that may distinguish your comment;
April 23, 2025 at 8:09 PM
How to Make Your Comments Effective Effective
public comments often have one or more of the following characteristics: (1) an introduction where you explain why you are interested in the regulation and highlight any experience with the subject of the rule that may distinguish your comment;
public comments often have one or more of the following characteristics: (1) an introduction where you explain why you are interested in the regulation and highlight any experience with the subject of the rule that may distinguish your comment;
Thank you Brian!
March 6, 2025 at 3:53 PM
Thank you Brian!
Click here to find your local representative and let them know how important funding American science is www.house.gov/representati...
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www.house.gov
March 6, 2025 at 3:41 PM
Click here to find your local representative and let them know how important funding American science is www.house.gov/representati...
Support for government funding agencies like @NIH, @VAResearch, @NSF and many more is essential to understanding health and disease, and finding the next generation of cures. And basic discoveries made one day, help to yield clinical breakthroughs years down the road.
March 6, 2025 at 3:41 PM
Support for government funding agencies like @NIH, @VAResearch, @NSF and many more is essential to understanding health and disease, and finding the next generation of cures. And basic discoveries made one day, help to yield clinical breakthroughs years down the road.
This project is the definition of “high risk, high reward”. It took us years to get here, and was fully dependent on intramural and extramural NIH funding. This is only one science story, but the careers of scientists like me have similar ones.
March 6, 2025 at 3:41 PM
This project is the definition of “high risk, high reward”. It took us years to get here, and was fully dependent on intramural and extramural NIH funding. This is only one science story, but the careers of scientists like me have similar ones.
These discoveries, along with our unpublished data, hinted that age-related processes repress CD73 expression in vessels, and that the lack of CD73-mediated adenosine production impacts methionine cycle substrate availability.
March 6, 2025 at 3:40 PM
These discoveries, along with our unpublished data, hinted that age-related processes repress CD73 expression in vessels, and that the lack of CD73-mediated adenosine production impacts methionine cycle substrate availability.
We also made progress towards understanding the role of the damaged elastic lamina observed in the patient vessel specimens tinyurl.com/bdzx57c4
Ecto-5′-nucleotidase (Nt5e/CD73)-mediated adenosine signaling attenuates TGFβ-2 induced elastin and cellular contraction | American Journal of Physiology-Cell Physiology | American Physiological Socie...
Arterial calcification due to deficiency of CD73 (ACDC) is a rare genetic disease caused by a loss-of-function mutation in the NT5E gene encoding the ecto-5′-nucleotidase (cluster of differentiation 7...
tinyurl.com
March 6, 2025 at 3:40 PM
We also made progress towards understanding the role of the damaged elastic lamina observed in the patient vessel specimens tinyurl.com/bdzx57c4
Our @atvbahajournals study not only elucidated the mechanisms underlying the calcification in ACDC patients, but for the first time showed that molecular signatures of ACDC, that is, low CD73 and high FOXO1 and TNAP, are also found in the #MAC of patients with peripheral artery disease #PAD
March 6, 2025 at 3:40 PM
Part of the “not easy” part, is that mice deficient in CD73 do not recapitulate the human disease de novo! tinyurl.com/9f5m5rnu, tinyurl.com/3cnz5sxs, tinyurl.com/3n425axk
Frontiers | Cell Phenotype Transitions in Cardiovascular Calcification
Cardiovascular calcification was originally considered a passive, degenerative process, however with the advance of cellular and molecular biology techniques...
tinyurl.com
March 6, 2025 at 3:39 PM
Part of the “not easy” part, is that mice deficient in CD73 do not recapitulate the human disease de novo! tinyurl.com/9f5m5rnu, tinyurl.com/3cnz5sxs, tinyurl.com/3n425axk
My lab started digging further into the mechanisms driving #ACDC pathogenesis, but it was not easy! Five years after starting my lab, we finally published our follow-up paper which found a lack CD73-generated adenosine promoted FOXO1 nuclear localization tinyurl.com/42xyktvh
Dysregulation of FOXO1 (Forkhead Box O1 Protein) Drives Calcification in Arterial Calcification due to Deficiency of CD73 and Is Present in Peripheral Artery Disease | Arteriosclerosis, Thrombosis, an...
Objective: The recessive disease arterial calcification due to deficiency of CD73 (ACDC) presents
with extensive nonatherosclerotic medial layer calcification in lower extremity arteries.
Lack of CD73...
tinyurl.com
March 6, 2025 at 3:39 PM
My lab started digging further into the mechanisms driving #ACDC pathogenesis, but it was not easy! Five years after starting my lab, we finally published our follow-up paper which found a lack CD73-generated adenosine promoted FOXO1 nuclear localization tinyurl.com/42xyktvh
At Pitt I also started working on calcific aortic valve disease, but I’ll save that story for another time (but see our cool new paper here: tinyurl.com/yu2tadwk!)
tinyurl.com
March 6, 2025 at 3:39 PM
At Pitt I also started working on calcific aortic valve disease, but I’ll save that story for another time (but see our cool new paper here: tinyurl.com/yu2tadwk!)