Steven Salzberg
stevensalzberg.bsky.social
Steven Salzberg
@stevensalzberg.bsky.social
Bloomberg Distinguished Professor of BME, CS, and Biostats at Johns Hopkins Univ., tennis player, @StevenSalzberg1 on Twitter, lab: salzberg-lab.org, Substack blog: stevensalzberg.substack.com
actually it reminds me more of finding 1000s of human contaminants annotated as proteins within draft bacterial genomes in GenBank, which we published in 2018 (and @aphillippy.bsky.social knows this work): pubmed.ncbi.nlm.nih.gov/31064768/
Human contamination in bacterial genomes has created thousands of spurious proteins - PubMed
Contaminant sequences that appear in published genomes can cause numerous problems for downstream analyses, particularly for evolutionary studies and metagenomics projects. Our large-scale scan of com...
pubmed.ncbi.nlm.nih.gov
October 14, 2025 at 3:05 PM
this is hilarious. AI fails again 🤣
September 9, 2025 at 3:38 PM
Reposted by Steven Salzberg
We also see the same patterns in other datasets:
📊 PCAWG
📊 TCGA - Cleaner signals produced by a fantastic paper today from Peter Ge, @stevensalzberg.bsky.social & team)

www.science.org/doi/10.1126/...
Comprehensive analysis of microbial content in whole-genome sequencing samples from The Cancer Genome Atlas project
An analysis of TCGA whole-genome sequencing samples yields a comprehensive resource for investigating the role of microbes in cancer.
www.science.org
September 3, 2025 at 7:00 PM
Congrats @kuanhaochao.bsky.social ! It's been great having you in the lab, and I can't wait to see what you do next!
August 27, 2025 at 2:06 AM
I agree that it's clearly illegal to put all grant funding under the absolute control of OMB and Russell Vought. But did anyone notice that NIH has not issued a single new R01 award (or competing renewal) since Aug 1? So the halt last week, which was supposedly overruled, seems to have happened?
August 8, 2025 at 2:18 PM
Truly awful behavior by OMB and Vought. And in case no one has noticed, NIH has issued zero new R01s or competing renewal R01s since August 1. So it seems they did in fact pause all funding last week, despite reports to the contrary.
August 8, 2025 at 2:16 PM
I guess you've been reading the latest papers on deep learning models such as AlphaGenome and Evo2? 🤣
July 27, 2025 at 2:16 PM
I listened to the clip. Vought is telling outrageous lies that he knows to be false. He is just an evil guy, there's no other way to interpret it.
July 27, 2025 at 2:14 PM
I don't understand how you get to 5/8. If you fully fund a 4-year grant, doesn't that cost 4 times as much as funding just the first year? And what if a grant is in year 1 out of 4 - does this mean they fund the remaining 3 years now? How much of each year's budget goes to new grants on average?
July 23, 2025 at 7:31 PM
well, if you delete it, then you've lost your 23andMe account. If you signed up in the first place, you presumably found some usefulness in that. I'm saying that the upside (whatever subjective value that is) outweighs the downside for me, and for me the downside is very small.
July 20, 2025 at 9:36 PM